A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 2004

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Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei, Soo-Jin Choi, Romain Parent, Carole Guillaume, Christiane Deregnaucourt, Christiane Delarbre, David M. Ojcius, Jean-Jacques Montagne, Marie-Louise L. Celerier, Aude Phelipot, Mohamed Amiche, Jordi Molgo, Jean-Michel Camadro, and Catherine Guette

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Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-associated glycosaminoglycans, Toni Darville, Saul Yedgar, M. Krimsky, C. W. Andrews Jr., Thomas Jungas, and David M. Ojcius

Suicide gene therapy for oral cancer: apoptosis or necrosis?, A. Delurgio, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

Serum-resistant HSVtk/ganciclovir gene therapy in oral cancer cells, Basma Fallah, JoMarie Monzon-Duller, Krystyna Konopka, and Nejat Düzgüneş

Shape parameter of DNA-lipoplex compared to polysaccharide-lipid complex, Sadao Hirota, Y. Takaoka, S. Ohi, Y. Sun, and Nejat Düzgüneş

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Cell death, BAX activation, and HMGB1 release during infection with Chlamydia, Thomas Jungas, Philippe Verbeke, Toni Darville, and David M. Ojcius

The effect of daily budesonide therapy on IL-10 in a murine model of asthma, Kameswari S. Konduri, Sandhya D. Nandedkar, D. A. Rickaby, J. D. Hemderson, and Nejat Düzgüneş

AmBisome inhibits the adherence of Candida albicans to HeLa cells, Krystyna Konopka, Barbara Dorocka-Bobkowska, and Nejat Düzgüneş

Cell-surface heparan sulfate and HIV-1 infection of differentiated THP-1 cells, Krystyna Konopka, Aaron Lee, JoMarie Monzon-Duller, and Nejat Düzgüneş

The effect of secretory leukocyte proteinase inhibitor (SLPI) in a murine model of asthma, Sandhya D. Nandedkar, Kameswari S. Konduri, Nejat Düzgüneş, D. A. Rickaby, and J. D. Hemderson

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A mouse model of human adaptive immune functions: HLA-A2.1-HLA-DR1-transgenic H-2 class I-/class II-knockout mice, Anthony Pajot, Marie-Louise Michel, Nicolas Fazilleau, Veronique Pancre, Claude Auriault, David M. Ojcius, Francois A. Lemonnier, and Yu-Chun Lone

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Comparison of HLA-DR1-directed T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules, Anthony Pajot, Veronique Pancre, Nicolas Fazilleau, Marie-Louise Michel, Gerhild Angyalosi, David M. Ojcius, Claude Auriault, Francois A. Lemonnier, and Yu-Chun Lone

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On the formulation of pH-sensitive liposomes with long circulation times, Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, and Maria C. Pedroso De Lima

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Comparison of the shape parameters of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes, Yan Sun, Xingju Yu, Yasuyuki Takaoka, Sho Ichi Oh-I, Nejat Düzgüneş, and Sadao Hirota

Poster, Nan (Tori) Xiao

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Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis, Özlem Yilmaz, Thomas Jungas, Philippe Verbeke, and David M. Ojcius

Submissions from 2003

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Increased receptor-mediated gene delivery to the liver by protamine-enhanced-asialofetuin-lipoplexes, M. A. Arangoa, Nejat Düzgüneş, and C. Tros de Ilarduya

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Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion, Patricia Boya, Karine Andreau, Delphine Poncet, Naoufal Zamzami, Jean-Luc Perfettini, Didier Metivier, David M. Ojcius, Marja Jäättelä, and Guido Kroemer

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At the innate frontiers between mother and fetus: linking abortion with complement activation, Stephane M. Caucheteux, Colette Kanellopoulos-Langevin, and David M. Ojcius

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Inhibition of chlamydial infectious activity due to P2X7 receptor-dependent phospholipase D activation, Robson Coutinho-Silva, Lynn Stahl, Marie-Noelle Raymond, Thomas Jungas, Geoffrey Burnstock, Toni Darville, David M. Ojcius, and Philippe Verbeke

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Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection, Toni Darville, Joshua M. O'Neill, Charles W. Andrews Jr., Uma M. Nagarajan, Lynn Stahl, and David M. Ojcius

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Influence of antifungal polyenes on the adhesion of Candida albicans and Candida glabrata to human epithelial cells in vitro, Barbara Dorocka-Bobkowska, Krystyna Konopka, and Nejat Düzgüneş

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Cationic liposomes for gene delivery: Novel cationic lipids and enhancement by proteins and peptides, Nejat Düzgüneş, Conchita Tros de Ilarduya, Sérgio Simões, Renat I. Zhdanov, Krystyna Konopka, and Maria C. Pedroso De Lima

Serum-resistant gene delivery to oral cancer cells by the polyamine reagent GeneJammer, Basma Fallah, JoMarie Monzon-Duller, Krystyna Konopka, and Nejat Düzgüneş

Serum-resistant HSV-tk/ganciclovir gene therapy in oral cancer cells via non-viral vectors, Basma Fallah, JoMarie Monzon-Duller, Krystyna Konopka, and Nejat Düzgüneş

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Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface, Colette Kanellopoulos-Langevin, Stephane M. Caucheteux, Philippe Verbeke, and David M. Ojcius

Gene delivery to oral cancer cells by lipid-DNA complexes containing human serum albumin, A. Kim, JoMarie Monzon-Duller, Krystyna Konopka, and Nejat Düzgüneş

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Efficacy of liposomal budesonide in experimental asthma, Kameswari S. Konduri, Sandhya Nandedkar, Nejat Düzgüneş, Vincent Suzara, James Artwohl, Ralph Bunte, and Pattisapu R.J. Gangadharam

Anti-HIV activity of newly cloned secretory leukocyte protease inhibitor (SLPI), Krystyna Konopka, Nancy R. Shine, Susan C. Wang, Nejat Düzgüneş, and Christian P. Whitman

Anti-HIV activity of newly cloned secretory leukocyte protease inhibitor (SLPI) in human macrophages, Krystyna Konopka, Nancy R. Shine, Susan C. Wang, Nejat Düzgüneş, and Christian P. Whitman

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Changes of sodium ion compartmentalization in biological systems due to pathological states. An NMR study, M. Lupu, David M. Ojcius, Jean-Luc Perfettini, J. Patry, J. L. Dimicoli, and J. Mispelter

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Characterization of a gene encoding two isoforms of a mitochondrial protein upregulated by cyclosporin A in activated T cells, Laurent Mascarell, Rodolphe Auger, Andres Alcover, David M. Ojcius, Thomas Jungas, Veronique Cadet-Daniel, Jean M. Kanellopoulos, and Paolo Truffa-Bacchi

Transcription factor NF-B binding sites in the CMV promoter as an inhibitor of HIV replication, M. Milnes, Krystyna Konopka, and Nejat Düzgüneş

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Cationic liposomes for gene delivery: From biophysics to biological applications, Maria C. Pedroso de Lima, S. Neves, A. Filipe, Nejat Düzgüneş, and S. Simões

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Cell death and inflammation during infection with the obligate intracellular pathogen, Chlamydia, Jean-Luc Perfettini, Veronique Hospital, Lynn Stahl, Thomas Jungas, Philippe Verbeke, and David M. Ojcius

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Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response, Jean-Luc Perfettini, David M. Ojcius, Charles W. Andrews Jr., Stanley J. Korsmeyer, Roger G. Rank, and Toni Darville

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Efficacies of cyclodextrin-complexed and liposome-encapsulated clarithromycin against Mycobacterium avium complex infection in human macrophages, Isam Ismail Salem and Nejat Düzgüneş

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Efficacy of clofazimine-modified cyclodextrin against Mycobacterium avium complex in human macrophages, Isam Ismail Salem, Gerhard Steffan, and Nejat Düzgüneş

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The shape parameter of liposomes and DNA-lipid complexes determined by viscometry utilizing small sample volumes, Yan Sun, X. Li, Nejat Düzgüneş, Y. Takaoka, S. Ohi, and S. Hirota

Viscometry for determining shape parameter of DNA-lipid complex, Y. Sun, Nejat Düzgüneş, and Sadao Hirota

Gene delivery by transferrin and asialofetuin-lipoplexes in the treatment of hepatocellular carcinoma, M. Conchita Tros de Ilarduya, Miguel A. Arangoa, Nejat Düzgüneş, and Cheng Qian

Determination of Novel Ruthenium Anti- Tumour Compounds in Plasma by High Performance Liquid Chromatography and Derivatization, Benjamin David Zeitlin, C. Henry, Duncan I. Jodrell, and Jeffrey Cummings

Submissions from 2002

Risk factors for periodontitis in HIV+ patients, T. Alpagot, Nejat Düzgüneş, Aaron Lee, C. Bell, D. W. Chambers, and G. Gowdey

Treatment of hepatocellular carcinoma by asialofetuin lipoplexes carrying IL-12 plasmid, Miguel A. Arangoa, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

Enhanced gene delivery by asialofetuin-liposomes for the treatment of hepatocellular carcinoma, Miguel A. Arangoa, Cheng Qian, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

The influence of antifungal polyenes on in vitro adherence of Candida to epithelial cells, Barbara Dorocka-Bobkowska, Krystyna Konopka, and Nejat Düzgüneş

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Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease, Arun K. Ghosh, Elizabeth Pretzer, Hanna Cho, Khaja Azhar Hussain, and Nejat Düzgüneş

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Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator, Thomas Jungas, Iris Motta, Francis Duffieux, Pascale Fanen, Veronique Stoven, and David M. Ojcius

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Expression of CD4 controls the susceptibility of THP-1 cells to infection by R5 and X4 HIV type 1 isolates, Krystyna Konopka and Nejat Düzgüneş

The SV40 promoter/enhancer element in trans stimulates HIV-1 LTR-driven gene expression, Krystyna Konopka and Nejat Düzgüneş

Transfection of HeLa, HEK293 and HSC-3 cells by transferrin lipoplexes, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

Lipid-mediated gene delivery to HSC-3 and HEK293 cells in the presence of serum, A. Lim, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

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Absence of weight loss during Cryptosporidium infection in susceptible mice deficient in Fas-mediated apoptosis, Iris Motta, Mathieu Gissot, Jean M. Kanellopoulos, and David M. Ojcius

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Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability, Isabel Nunes-Correia, Ana Eulálio, Shlomo Nir, Nejat Düzgüneş, João Ramalho-Santos, and Maria C. Pedroso De Lima

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MHC and MHC-related proteins as pleiotropic signal molecules, David M. Ojcius, Christiane Delarbre, Philippe Kourilsky, and Gabriel Gachelin

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Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis), Jean-Luc Perfettini, Toni Darville, Alice Dautry-Varsat, Roger G. Rank, and David M. Ojcius

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Modulation of apoptosis during infection with Chlamydia, Jean-Luc Perfettini, Mathieu Gissot, Philippe Souque, and David M. Ojcius

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Role of Bcl-2 family members in caspase-independent apoptosis due to Chlamydia infection, Jean-Luc Perfettini, John C. Reed, Nicole Israel, Jean-Claude Martinou, Alice Dautry-Varsat, and David M. Ojcius

HSV-tk/ganciclovir-based non-viral gene therapy in human oral cancer cells, S. Saghezchi, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

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Secretory leukocyte protease inhibitor: Inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein, Nancy R. Shine, S. C. Wang, Krystyna Konopka, E. A. Burks, Nejat Düzgüneş, and C. P. Whitman

Newly cloned secretory leukocyte protease inhibitor (SLPI) inhibits HIV-1 infection of monocytic THP-1 cells, Nancy R. Shine, Susan C. Wang, Krystyna Konopka, Elizabeth A. Burks, Nejat Düzgüneş, and Christian P. Whitman

Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles, Sérgio Simões, C. Fonseca, Henrique Faneca, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes, Conchita Tros De Ilarduya, M. A. Arangoa, M. J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 2001

Asialofetuin lipoplexes for enhanced transfection of hepatic cells, Miguel A. Arangoa, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

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Characterization of a monoclonal antibody reacting with antigen-4 domain of gp900 in Cryptosporidium parvum invasive stages, Alain Bonnin, David M. Ojcius, Philippe Souque, Debra A. Barnes, Patricia S. Doyle, Jiri Gut, Richard G. Nelson, Carolyn Petersen, and Jean-Francois Dubremetz

Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci, Robson Coutinho-Silva, Jean-Luc Perfettini, Pedro M. Persechini, Alice Dautry-Varsat, and David M. Ojcius

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Lipid assemblies for drug delivery, Nejat Düzgüneş

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Delivery of novel macromolecular drugs against HIV-1, Nejat Düzgüneş, Sérgio Simões, Krystyna Konopka, John J. Rossi, and Maria C. Pedroso De Lima

HIV-1 LTR- and SV40-driven gene expression is inhibited by the CMV promoter, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Secretory leukocyte protease inhibitor and HIV-1 infection of THP-1 cells, Krystyna Konopka, Nancy R. Shine, Susan C. Wang, Christian P. Whitman, and Nejat Düzgüneş

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Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

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Radical changes to chlamydial taxonomy are not necessary just yet, J. Schachter, R. S. Stephens, P. Timms, C. Kuo, Patrik M. Bavoil, S. Birkelund, J. Boman, H. Caldwell, L. A. Campbell, M. Chernesky, G. Christiansen, I. N. Clarke, C. Gaydos, J. T. Grayston, T. Hackstadt, R. Hsia, B. Kaltenboeck, M. Leinonnen, David M. Ojcius, G. McClarty, J. Orfila, R. Peeling, M. Puolakkainen, T. C. Quinn, R. G. Rank, J. Raulston, G. L. Ridgeway, P. Saikku, W. E. Stamm, D. T. Taylor-Robinson, S. P. Wang, and P. B. Wyrick

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On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes, Sérgio Simões, Vladimir Slepushkin, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Submissions from 2000

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Closing in on Chlamydia and its intracellular bag of tricks, Patrik M. Bavoil, Ru-ching Hsia, and David M. Ojcius

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Fluorescent labelling of intracellular bacteria in living host cells, Haralabia Boleti, David M. Ojcius, and Alice Dautry-Varsat

Intracellular delivery of anti-HIV agents via pH-sensitive liposomes and transferrin-lipoplexes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, Nan S. Lee, John J. Rossi, Maria C. Pedroso de Lima, and Krystyna Konopka

Superior inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides encapsulated in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Enhanced inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides delivered in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, John J. Rossi, E. De Clercq, V. P. Antao, M. L. Collins, and Maria C. Pedroso de Lima

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La notion de danger, Jean M. Kanellopoulos and David M. Ojcius

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells is not affected by treatment with heparinase, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

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Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan Sook Lee, John Rossi, and Nejat Düzgüneş

The CMV promoter inhibits HIV-1 LTR- and SV40-driven gene expression, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Therapy for oral squamous cell carcinoma using cationic lipid-DNA complexes for gene delivery, N. C. Moser, V. V. Suzara, Krystyna Konopka, and Nejat Düzgüneş

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Effect of Chlamydia trachomatis infection and subsequent TNFa secretion on apoptosis in the murine genital tract, Jean-Luc Perfettini, Toni Darville, Gabriel Gachelin, Philippe Souque, Michel Huerre, Alice Dautry-Varsat, and David M. Ojcius

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Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Efficient gene transfer by transferrin lipoplexes in the presence of serum, Conchita Tros De Ilarduya and Nejat Düzgüneş

Controlled gene delivery to cultured rat hepatocytes and adipocytes by liposomes containing transferrin, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Transfection of primary rat hepatocytes and adipocytes by transferrin lipoplexes, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 1999

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Chlamydia trachomatis, ennemi intérieur : de la biologie moléculaire aux modèles animaux, Patrik M. Bavoil, David M. Ojcius, Alice Dautry-Varsat, A. Souriau, F. Bernard, A. Rodolakis, and R.-C. Hsia

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Chlamydia infection or epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth, Haralabia Boleti, Alexandre Benmerah, David M. Ojcius, Nadine Cerf-Bensussan, and Alice Dautry-Varsat

P2Z-P2X7 receptor-mediated apoptosis of dendritic cells, Robson Coutinho-Silva, Pedro M. Persechini, R. C. Bisaggio, Jean-Luc Perfettini, A. C. T. Sa Neto, Jean M. Kanellopoulos, I. Motta, Alice Dautry-Varsat, and David M. Ojcius

Science by consensus: Why the NIH grant review system must be changed, Nejat Düzgüneş

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Mechanisms and kinetics of liposome-cell interactions, Nejat Düzgüneş and Shlomo Nir

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Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir A. Slepushkin, Krystyna Konopka, Diana Flasher, and Maria C. Pedroso De Lima

Enhanced antiviral effect of ribozymes, PMEA and antisense oligonucleotides in HIV-1-infected macrophages by delivery in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Human serum albumin enhances gene delivery by lipoplexes and confers resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Human serum albumin-lipoplexes: Enhanced gene delivery and resistance to serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Lipoplexes associated with human serum albumin or transferrin: Enhanced gene delivery to cell lines and macrophages, and resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, C. Tros, Diana Flasher, and Maria C. Pedroso de Lima

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells, E. Farge, David M. Ojcius, A. Subtil, and Alice Dautry-Varsat