A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 1991

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Plasma membrane-associated proteins with the ability to partially inhibit perforin-mediated lysis, David M. Ojcius, Sylviane Muller, Cynthia S. Hasselkus-Light, John Ding-E. Young, and Shibo Jiang

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Cytolytic and ion channel forming properties of the N-terminus of lymphocyte perforin, David M. Ojcius, Pedro M. Persechini, Li-Mou Zheng, Paulo C. Notaroberto, Sandro C. Adeodato, and John Ding-E. Young

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Cytolytic peptides and proteins: Is there a common structural motif?, David M. Ojcius and John Ding-E. Young

Subcellular localization of perforin and serine esterase in lymphokine-activated killer (LAK) cells and cytotoxic T cells by immunogold labelling, David M. Ojcius, L. M. Zheng, E. C. Sphicas, A. Zychilinsky, and John Ding-E. Young

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Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes, David M. Ojcius, Arturo Zychlinsky, Li-Mou Zheng, and John Ding-E. Young

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Fusion of Sendai virus with human HL-60 and CEM cells: different kinetics of fusion for two isolates, Maria C. Pedroso de Lima, Shlomo Nir, Diana L. Flasher, Karin Klappe, Dick Hoekstra, and Nejat Düzgüneş

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Expression of lymphocyte perforin in the mouse uterus during pregnancy, Li-Mou Zheng, Chau-Ching Liu, David M. Ojcius, and John Ding-E. Young

Immunogold labelling of perforin and serine esterases in granulated metrial gland cells, Li-Mou Zheng, David M. Ojcius, Chau-Ching Liu, M. D. Kramer, M. M. Simon, E. L. Parr, and John Ding-E. Young

Role of granulated metrial gland cells in the immunology of pregnancy, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

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Extracellular ATP as a trigger for apoptosis or programmed cell death, Li-Mou Zheng, Arturo Zychlinsky, Chau-Ching Liu, David M. Ojcius, and John Ding-E. Young

Submissions from 1990

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Isolation and characterization of the gene encoding the muscle-specific isozyme of human phosphoglycerate mutase

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Cholesterol Interactions with Tetracosenoic Acid Phospholipids in Model Cell Membranes: Role of the Double-Bond Position, Eser Ayanoglu, Bich Huong Chiche, Mark Beatty, Carl Djerassi, and Nejat Düzgüneş

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In situ mapping of the muscle-specific form of phosphoglycerate mutase gene to human chromosome 7p12-7p13, Judit Castella-Escola, M. G. Mattei, David M. Ojcius, E. Passage, C. Valentin, and M. Cohen-Solal

Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor, Robert J. Debs, L. P. Freedman, S. Edmunds, K. L. Gaensler, Nejat Düzgüneş, and K. R. Yamamoto

Immunomodulatory and Toxic Effects of Free and Liposome-encapsulated Tumor Necrosis Factor a in Rats1, Robert J. Debs, Henry J. Fuchs, Ramila Philip, Elisa N. Brunette, Nejat Düzgüneş, Judd E. Shellito, Denny Liggitt, and John R. Patton

HIV-1 blocks monocyte-mediated lysis of HIV-infected cells: Role of the HIV envelope protein, Robert J. Debs, John Krowka, Elisa N. Brunette, Daniel Stites, Ramila Philip, and Nejat Düzgüneş

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Monocyte-Mediated Lysis of HIV-Infected Tumor Cells, Robert J. Debs, John Krowka, Daniel Stites, Elisa N. Brunette, Nejat Düzgüneş, and Ramila Philip

Molecular control of vesicle aggregation and membrane fusion: Hypotheses on bile vesicles, Nejat Düzgüneş

Developments in liposome-mediated chemotherapy and immunotherapy of HIV and Mycobacterium avium complex infections, Nejat Düzgüneş, Krystyna Konopka, C. Larsen, Diana Flasher, John Krowka, Daniel Stites, B. Davis, D. Ashtekar, Pattisapu Gangadharam, and Robert Debs

Fusion of immunodeficiency, influenza and Sendai viruses with liposomes and cultured cells, Nejat Düzgüneş, C. Larsen, Maria C. Pedroso de Lima, Dennis Alford, Diana Flasher, L. Young, T. McGraw, M. Jennings, K. Klappe, Dick Hoekstra, and Shlomo Nir

Development of a nucleoplasmic reticulum in CV1 cells following incorporation of cationic DOTMA liposomes, Daniel S. Friend, Robert Debs, L. Freedman, Nejat Düzgüneş, and K. Yamamoto

Interaction between DOTMA liposomes, CV1 and U937 cells, and their isolated nuclei, Daniel S. Friend, Robert J. Debs, and Nejat Düzgüneş

Chemotherapeutic assessment of free and liposome-encapsulated streptomycin against Mycobacterium avium complex infections in beige mice, Pattisapu R. J. Gangadharam, N. Ghori, D. Ashtekar, Nejat Düzgüneş, and Robert Debs

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Purification of a membrane-associated serine esterase from murine cytotoxic T lymphocytes by a single reverse phase column, Shibo Jiang, Cynthia S. Hasselkus-Light, David M. Ojcius, and John Ding-E. Young

Resistance of cytolytic lymphocytes to perforin-mediated killing: Inhibition of perforin binding activity by surface membrane proteins, Shibo Jiang, David M. Ojcius, Pedro M. Persechini, and John Ding-E. Young

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Perforin binding to cells and lipid membranes determined by a simple competition assay, Shibo Jiang, David M. Ojcius, and John Ding-E. Young

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Differential effects of free and liposome encapsulated amikacin on the survival of Mycobacterium avium complex in mouse peritoneal macrophages, L. Kesavalu, Jayne A. Goldstein, Robert J. Debs, Nejat Düzgüneş, and Pattisapu R.J. Gangadharam

Inhibition and enhancement of HIV-1 infectivity by liposomes, Krystyna Konopka, B. R. Davis, C. E. Larsen, Dennis R. Alford, Robert J. Debs, and Nejat Düzgüneş

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Liposomes modulate human immunodeficiency virus infectivity, Krystyna Konopka, B. R. Davis, C. E. Larsen, D. R. Alford, Robert J. Debs, and Nejat Düzgüneş

Lymphocyte proliferative responses to soluble and liposome-conjugated envelope peptides of HIV-1, J. Krowka, D. Stites, Robert J. Debs, C. Larsen, Jane Fedor, E. Brunette, and Nejat Düzgüneş

Fusion of HIV-1 with liposomes, C. Larsen, Dennis R. Alford, M. Jennings, Robert Debs, and Nejat Düzgüneş

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Fusion of simian immunodeficiency virus with liposomes and erythrocyte ghost membranes: Effects of lipid composition, pH and calcium, Charles E. Larsen, D. R. Alford, L. J.T. Young, T. P. McGraw, and Nejat Düzgüneş

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Fusion of enveloped viruses with cells and liposomes - Activity and inactivation, Shlomo Nir, Nejat Düzgüneş, Maria C. Pedroso De Lima, and Dick Hoekstra

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Resistance to the pore forming protein of cytotoxic T cells: comparison of target cell membrane rigidity, David M. Ojcius, Shibo Jiang, Pedro M. Persechini, Judith Storch, and John Ding-E. Young

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Restriction factors of homologous complement: A new candidate?, David M. Ojcius, Shibo Jiang, and John Ding-E. Young

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A role for pore-forming proteins in the pathogenesis by parasites?, David M. Ojcius and John Ding-E. Young

Cell-mediated killing: effector mechanisms and mediators, David M. Ojcius and John Ding-E. Young

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Characterization of the inhibitory effect of lysolipids on perforin-mediated hemolysis, David M. Ojcius and John Ding-E. Young

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Cytotoxic effector mechanisms, David M. Ojcius and John Ding-E. Young

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Molecular mechanisms of calcium-induced membrane fusion, Demetrios Papahadjopoulos, Shlomo Nir, and Nejat Düzgüneş

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Interaction of antimycobacterial and anti-pneumocystis drugs with phospholipid membranes, Maria C. Pedroso de Lima, Bich Huong Chiche, Robert J. Debs, and Nejat Düzgüneş

Fusion of Sendai and influenza viruses with cultured cells: Insights towards cell infection, Maria C. Pedroso de Lima, João Ramalho-Santos, M. F. Martins, and Nejat Düzgüneş

Submissions from 1989

Comparative study of fluorescent assays for contents mixing and leakage in lipid vesicles, Dennis Alford, Nejat Düzgüneş, and Joe Bentz

Inositol phosphate formation is regulated by neurotransmitters and neuropeptides in cultured human non-pigmented ciliary epithelium, R. B. Cook, N. Bazan, Nejat Düzgüneş, and J. R. Polansky

Membrane-associated TNF retains bioactivity in the presence of neutralizing anti-TNF antibodies, Robert J. Debs, Nejat Düzgüneş, Elisa N. Brunette, B. Fendly, J. Patton, and Ramila Philip

Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies, Robert J. Debs, Nejat Düzgüneş, E. N. Brunette, B. Fendly, J. Patton, and Ramila Philip

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Fusion of Liposomes Containing a Novel Cationic Lipid, N-[2,3-(Dioleyloxy)propyl]-N,N,N-trimethylammonium: Induction by Multivalent Anions and Asymmetric Fusion with Acidic Phospholipid Vesicles, Nejat Düzgüneş, Jayne A. Goldstein, Daniel S. Friend, and Philip L. Feigner

Therapy of Mycobacterium avium complex (MAC) infections in beige mice and peritoneal macrophages with liposome-encapsulated aminoglycosides and cytokines, Nejat Düzgüneş, L. Kesavalu, Veluchamy K. Permual, Jayne A. Goldstein, Elisa N. Brunette, Robert J. Debs, and Pattisapu R. J. Gangadharam

Liposome encapsulation facilitates enhanced killing effect of amikacin on Mycobacterium avium complex (MAC) in beige mice and macrophages, Pattisapu R. J. Gangadharam, L. Kesavalu, Jayne Goldstein, Robert J. Debs, and Nejat Düzgüneş

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Lectin-carbohydrate interactions in model and biological membrane systems., Dick Hoekstra and Nejat Düzgüneş

In vitro lymphocyte proliferative responses to recombinant and synthetic peptide antigens of HIV-1, John Krowka, Daniel Stites, K. Steimer, and Nejat Düzgüneş

Fusion of simian immunodeficiency virus (SIVmac) with liposomes and erythrocyte ghosts, C. Larsen, Dennis Alford, L. Young, K-D. Lee, T. McGraw, and Nejat Düzgüneş

Fusion of simian immunodeficiency virus (SIVmac) with phospholipid vesicles, erythrocyte ghosts and T-cell lines, C. Larsen, Dennis Alford, L. Young, K-D. Lee, T. McGraw, and Nejat Düzgüneş

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Review of "Current Topics in Microbiology and Immunology: Cytotoxic Effector Mechanisms", David M. Ojcius and John Ding-E. Young

Submissions from 1988

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Unusual sponge phospholipids and their analogs. Synthesis and interactions with conventional phospholipids and cholesterol in model membranes, Eser Ayanoglu, Huiting Li, Carl Djerassi, and Nejat Düzgüneş

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La3+-induced fusion of phosphatidylserine liposomes. Close approach, intermembrane intermediates, and the electrostatic surface potential, Joe Bentz, D. R. Alford, J. Cohen, and Nejat Düzgüneş

Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor-alpha in rats, Robert J. Debs and H. J. Fuchs

Monocyte cytolytic function is mediated by CD4, and is inhibited by HIV, Robert J. Debs, John Krowka, Daniel Stites, Elisa N. Brunette, Nejat Düzgüneş, and Ramila Philip

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Membrane action of synthetic N-terminal peptides of influenza virus hemagglutinin and its mutants, Nejat Düzgüneş and Franco Gambale

Therapy of Mycobacterium avium-intracellulare complex infection in macrophages and the Beige mouse model: Therapy with free and liposome-encapsulated antibiotics and immunomodulators, Nejat Düzgüneş, Pattisapu R. J. Gangadharam, Veluchamy K. Permual, Jayne Goldstein, L. Kesavalu, Elisa N. Brunette, D. Yajko, W. K. Hadley, and Robert J. Debs

Lymphocyte proliferation in response to immunodominant and conserved HIV peptides coupled to liposomes, Nejat Düzgüneş, John F. Krowka, Robert J. Debs, Jane Fedor, V. Maino, and Daniel P. Stites

Liposome-coupled synthetic immunodominant HIV peptides induce proliferation of lymphocytes from HIV-seropositive individuals, Nejat Düzgüneş, John F. Krowka, Ramila Philip, V. C. Maino, and Daniel P. Stites

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Monolayer coupling in phosphatidylserine bilayers: Distinct phase transitions induced by magnesium interacting with one or both monolayers, Nejat Düzgüneş, C. Newton, K. Fisher, Jane Fedor, and Demetrios Papahadjopoulos

Treatment of Mycobacterium avium-intracellulare complex infection in macrophages and Beige mice by free and liposome-encapsulated tumor necrosis factor-alpha (TNF), Nejat Düzgüneş, Veluchamy K. Permual, Elisa N. Brunette, Pattisapu R. J. Gangadharam, and Robert J. Debs

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Treatment of mycobacterium avium-intracellulare complex (MAC) infection in macrophages and beige mice by free and liposome-encapsulated tumor necrosis factor-alpha (TNF), Nejat Düzgüneş, Veluchamy K. Perumal, E. N. Brunette, P. R.J. Gangadharam, and Robert J. Debs

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Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice, Nejat Düzgüneş, Veluchamy K. Perumal, L. Kesavalu, Jayne A. Goldstein, Robert J. Debs, and Pattisapu R.J. Gangadharam

Influence of synthetic peptides derived from viral envelope proteins on the permeability and fusion of phospholipid vesicles, Nejat Düzgüneş and S. A. Shavnin

Activity of free and liposome-encapsulated amikacin against Mycobacterium avium complex (MAC), Pattisapu R. J. Gangadharam, Veluchamy K. Permual, L. Kesavalu, Robert J. Debs, Jayne Goldstein, and Nejat Düzgüneş

Comparative activities of free and liposome encapsulated amikacin against Mycobacterium avium complex (MAC), Pattisapu R. J. Gangadharam, Veluchamy K. Permual, L. Kesavalu, Robert J. Debs, Jayne Goldstein, and Nejat Düzgüneş

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Activity of free and liposome encapsulated amikacin against mycobacterium avium complex (MAC), Pattisapu R.J. Gangadharam, Veluchamy K. Perumal, L. Kesavalu, Robert J. Debbs, Jayne Goldstein, and Nejat Düzgüneş

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Relation between the anion exchange protein in kidney medullary collecting duct cells and red cell band 3, Agnes Janoshazi, David M. Ojcius, Bruce Kone, Julian L. Seifter, and A. K. Solomon

Comparative mycobactericidal action of free and liposome encapsulated amikacin on Mycobacterium avium complex (MAC) in peritoneal macrophages, L. Kesavalu, Veluchamy K. Permual, Nejat Düzgüneş, Robert Debs, and Pattisapu R. J. Gangadharam

Recognition of HIV-1 envelope glycoprotein (ENVgp) by antibodies and T cells from HIV-infected individuals, John Krowka, V. Maino, H. Hollander, Nejat Düzgüneş, and Daniel Stites

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Analogs of unusual sponge phospholipids. Synthesis and thermotropic properties of 1,2-di-(6Z,9Z)-6,9-hexacosadienoyl phosphatidylcholine and phosphatidylethanolamine, Huiting Li, Nejat Düzgüneş, Eser Ayanoĝlu, and Carl Djerassi

Sites of p-chloromercuribenzene-sulfonate inhibition of red cell urea and water transport, David M. Ojcius and A. K. Solomon

Is an intact cytoskeleton required for native red cell urea and water transport?, David M. Ojcius, M. R. Toon, and A. K. Solomon

Interaction of Antimycobacterial and antipneumocystis drugs with phospholipid bilayers studied by differential scanning calorimetry, Maria C. Pedroso de Lima and Nejat Düzgüneş

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Positive correlation between cytosolic free calcium and surfactant secretion in cultured rat alveolar type II cells, Mark S. Pian, Leland G. Dobbs, and Nejat Düzgüneş

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Cholesterol affects divalent cation-induced fusion and isothermal phase transitions of phospholipid membranes, Sergei A. Shavnin, Maria C. Pedroso de Lima, Jane Fedor, Periann Wood, Joe Bentz, and Nejat Düzgüneş

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Interaction of erythrocyte protein 4.1 with phospholipids. A monolayer and liposome study, Kathleen A. Shiffer, Jon Goerke, Nejat Düzgüneş, Jane Fedor, and Stephen B. Shohet

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Interactions of The Low Molecular Weight Group of Surfactant-associated Proteins (sp 5–18) With Pulmonary Surfactant Lipids, Kathleen A. Shiffer, Samuel Hawgood, Nejat Düzgüneş, and Jon Goerke

The effects of the low molecular weight surfactant-associated proteins, SP-B and SP-C, on the thermotropic properties of various synthetic phospholipid membranes, Kathleen A. Shiffer, Samuel Hawgood, Nejat Düzgüneş, and Jon Goerke

Submissions from 1987

La3+ induced fusion of phosphatidylserine liposomes: Close approach, intermembrane intermediates and the electrostatic surface potential, Joe Bentz, Dennis Alford, J. Cohen, and Nejat Düzgüneş

Encapsulation of tumor necrosis factor (TNF) in liposomes: Characterization and effects on bioactivity, Robert J. Debs, Ramila Philip, Elisa N. Brunette, L. B. Epstein, and Nejat Düzgüneş

Lipid mixing during membrane aggregation and fusion, Nejat Düzgüneş, Theresa M. Allen, Jane Fedor, and Demetrios Papahadjopoulos

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Lipid Mixing during Membrane Aggregation and Fusion: Why Fusion Assays Disagree, Nejat Düzgüneş, Nejat Düzgüneş, Theresa M. Allen, Jane Fedor, Demetrios Papahadjopoulos, Demetrios Papahadjopoulos, and Theresa M. Allen

Membrane action of peptides from influenza hemagglutinin, Nejat Düzgüneş, F. Gambale, and Jane Fedor

Liposome-mediated therapy of Mycobacterium avium-intracellulare infections, Nejat Düzgüneş, Pattisapu Gangadharam, Jane Fedor, Veluchamy K. Permual, D. Perumal, D. Yajko, P. Minasi, D. Daleke, K. Hadley, and Robert Debs

Synexin-like proteins from human polymorphonuclear leukocytes. Identification and characterization of granule-aggregating and membrane-fusing activities, P. Meers, J. D. Ernst, Nejat Düzgüneş, K. L. Hong, Jane Fedor, I. M. Goldstein, and D. Papahadjopoulos

Calcium-induced membrane fusion: From liposomes to cells, Demetrios Papahadjopoulos, Paul Meers, J. D. Ernst, I. M. Goldstein, Nejat Düzgüneş, and Keelung Hong

Ionotropic phase transitions and fusion of phospholipid vesicles are modulated by cholesterol, Maria C. Pedroso de Lima and Nejat Düzgüneş

Activity of liposomal preparations on phagocytosis and intracellular multiplication of Mycobacterium avium complex (MAC), Veluchamy K. Permual, Pattisapu R. J. Gangadharam, Nejat Düzgüneş, Robert Debs, Jane Fedor, N. R. Podapati, and M. D. Iseman

Interactions of the 10K group of lung surfactant- associated proteins with lipids, Kathleen A. Shiffer, Samuel Hawgood, Nejat Düzgüneş, and Jon Goerke

Submissions from 1986

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Biophysical properties of unusual phospholipids and sterols from marine invertebrates, Eser Ayanoǧlu, Nejat Düzgüneş, W. M. Donald Wijekoon, and Carl Djerassi

Distinct phase transitions induced by magnesium interacting with one or both monolayers of phosphatidylserine vesicles, Nejat Düzgüneş, C. Newton, and Demetrios Papahadjopoulos

Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion, J. D. Ernst, Paul Meers, Keelung Hong, Nejat Düzgüneş, Demetrios Papahadjopoulos, and I. M. Goldstein

Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion., J. D. Ernst, P. Meers, Keeking Hong, Nejat Düzgüneş, Demetrios Papahadjopoulos, and I. M. Goldstein

Lectin-mediated agglutination and fusion of glycolipid/phospholipid vesicles: Effect of carbohydrate head-group size, calcium ions and spermine, Dick Hoekstra and Nejat Düzgüneş

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Ricinus communis Agglutinin-Mediated Agglutination and Fusion of Glycolipid-Containing Phospholipid Vesicles: Effect of Carbohydrate Head Group Size, Calcium Ions, and Spermine, Dick Hoekstra and Nejat Düzgüneş

Action of colicin E1 on liposomal membranes: Detection by the efflux of carboxyfluorescein and calcein, and the influx of thallium, C. Kayalar, E. Brueggeman, and Nejat Düzgüneş