A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 1995

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Liposome-mediated therapy of human immunodeficiency virus type-1 and mycobacterium infections, Nejat Düzgüneş, Diana L. Flasher, Elizabeth Pretzer, Krystyna Konopka, Vladimir A. Slepushkin, Gerhard Steffan, Isam I. Salem, M. Venkata Reddy, and Pattisapu R.J. Gangadharam

Liposome-encapsulated sparfloxacin, paromomycin, ciprofloxacin and clarithromycin for the therapy of Mycobacterium avium complex and Mycobacterium tuberculosis in macrophages, Nejat Düzgüneş, Diana Flasher, M. V. Reddy, Julieta Luna-Herrera, Isam I. Salem, and Pattisapu R. J. Gangadharam

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Therapy of Mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes, Pattisapu R.J. Gangadharam, D. R. Ashtekar, Diana L. Flasher, and Nejat Düzgüneş

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A monoclonal antibody to the gp120-CD4 complex has differential effects on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, F. Celada, and Nejat Düzgüneş

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Differential effects of a hydrophobic tripeptide on human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, and Nejat Düzgüneş

Infected macrophages and differentiated chronically infected THP-1HIV-1IIIB cells are more sensitive to cytotoxic effects of cationic liposomes than uninfected cells, Krystyna Konopka, Elizabeth Pretzer, Philip Felgner, and Nejat Düzgüneş

Cationic liposome-mediated delivery of anti-HIV-1 ribozyme to chronically infected cells, Krystyna Konopka, John J. Rossi, Philip Felgner, and Nejat Düzgüneş

Les mille et une ruses des microbes intracellulaires, David M. Ojcius and Alice Dautry-Varsat

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pH and calcium dependence of hemolysis due to Rickettsia prowazekii: comparison with phospholipase activity, David M. Ojcius, M. Thibon, C. Mounier, and Alice Dautry-Varsat

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Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus, Maria C. Pedroso de Lima, João Ramalho-Santos, Diana L. Flasher, Vladimir A. Slepushkin, Shlomo Nir, and Nejat Düzgüneş

Inhibition of HIV-1 infection of macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana Flasher, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability as novel delivery vehicles for anti-HIV and anti-cancer drugs, Vladimir A. Slepushkin and Nejat Düzgüneş

Development of pH-sensitive liposomes stable in serum for delivery of anti-sense oligonucleotides, Vladimir A. Slepushkin, Diana Flasher, Elizabeth Pretzer, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability, Vladimir Slepushkin and Nejat Düzgüneş

Liposome-bound cyclodextrin sulfates: a potential antiviral drug delivery system, Gerhard Steffan, C. Henke, H.J. Galla, and Nejat Düzgüneş

Submissions from 1994

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Picosecond fluorescence spectroscopy of a single-chain class I major histocompatibility complex-encoded protein in its peptide loaded and unloaded states, Kerstin Dittes, D. Gakamsky, Elisha Haas, David M. Ojcius, Philippe Kourilsky, Israel Pecht, and Gilad Haran

Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis, Richard C. Duke, R. Z. Witter, P. B. Nash, John Ding-E. Young, and David M. Ojcius

Inhibition of phagosome-lysosome fusion by microorganisms phagocytosed by macrophages, Nejat Düzgüneş

Membrane fusion activity of simian and human immunodeficiency virus: Differential molecular requirements for membrane lipid mixing, nucleocapsid entry and cell-cell fusion, Nejat Düzgüneş, L. Stamatatos, Krystyna Konopka, F. Celada, and Elizabeth Pretzer

Targeting liposomes to cells infected with human immunodeficiency virus type 1 (HIV-1), Diana Flasher, Krystyna Konopka, S. Chamow, P. Dazin, A. Ashkenazi, Elizabeth Pretzer, and Nejat Düzgüneş

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Liposome targeting to human immunodeficiency virus type 1-infected cells via recombinant soluble CD4 and CD4 immunoadhesin (CD4-IgG), Diana Flasher, Krystyna Konopka, Steven M. Chamow, Paul Dazin, Avi Ashkenazi, Elizabeth Pretzer, and Nejat Düzgüneş

Differential effects of a monoclonal antibody to the gp120-CD4 complex on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, E. Seravalli, F. Celada, and Nejat Düzgüneş

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Role of the CDR1 of the TCR β chain in the binding to a MHC-peptide complex, Yu-Chun Lone, Maria Bellio, Ada Prochnicka-Chalufour, David M. Ojcius, Nicolas Boissel, Tom H. M. Ottenhoff, Richard D. Klausner, Jean-Pierre Abastado, and Philippe Kourilsky

Major contribution of the Vb chain to the antigen specificity of a TCR, Yu-Chun Lone, David M. Ojcius, M. Bellio, Philippe Kourilsky, and J.-P. Abastado

Major histocompatibility complex class I molecules and resistance to infection by intracellular pathogens, David M. Ojcius, Christiane Delarbre, Philippe Kourilsky, and Gabriel Gachelin

Is antigen processing guided by major histocompatibility complex molecules?, David M. Ojcius, L. Gapin, Jean M. Kanellopoulos, and Philippe Kourilsky

Role for MHC class I molecules in selecting and protecting high affinity peptides in the presence of proteases, David M. Ojcius, P. Langlade-Demoyen, Gabriel Gachelin, and Philippe Kourilsky

Role of target membrane sialic acid in the fusion activity of influenza virus, João Ramalho-Santos, Nejat Düzgüneş, Diana Flasher, Shlomo Nir, and Maria C. Pedroso de Lima

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Ly-49-independent inhibition of NK cell-mediated cytotoxicity by a soluble MHC class I molecule, Claude Roth, Philippe Kourilsky, and David M. Ojcius

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Separate metabolic pathways leading to DNA fragmentation and apoptotic nuclear chromatin condensation, D. Sun, Shibo Jiang, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

Submissions from 1993

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A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd, Jean-Pierre Abastado, David M. Ojcius, Amanda Casrouge, Patrice Yeh, Ton N. M. Schumacher, Hidde L. Ploegh, and Philippe Kourilsky

Liposome-encapsulated antiviral agents inhibit HIV-1 replication in monocyte/macrophages and a chronically infected macrophage cell line, Nejat Düzgüneş, Diana Flasher, Elizabeth Pretzer, Krystyna Konopka, and S. Chamow

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Anionic liposomes inhibit human immunodeficiency virus type 1 (HIV-1) infectivity in CD4+ A3.01 and H9 cells, Krystyna Konopka, B. R. Davis, C. E. Larsen, and Nejat Düzgüneş

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Long-Term Noncytopathic Productive Infection of the Human Monocytic Leukemia Cell Line THP-1 by Human Immunedeficiency Virus Type 1 (HIV-1IIIB), Krystyna Konopka, Elizabeth Pretzer, Barbara Plowman, and Nejat Düzgüneş

Long-term noncytopathic productive infection of the human monocytic leukemia cell line THP-1 by HIV-1IIIB, Krystyna Konopka, Elizabeth Pretzer, B. Plowman, and Nejat Düzgüneş

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Human immunodeficiency virus type 1 (HIV-1) fusion with model membranes: kinetic analysis and the role of lipid composition, pH and divalent cations, Charles E. Larsen, Shlomo Nir, Dennis R. Alford, Myra Jennings, Kyung Dall Lee, and Nejat Düzgüneş

Dissociation of the peptide-MHC class I complex limits the binding rate of exogenous peptide, David M. Ojcius, Jean-Pierre Abastado, Amanda Casrouge, E. Mottez, L. Cabanie, and Philippe Kourilsky

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Binding of alanine-substituted peptides to the MHC class I protein Kd, David M. Ojcius, Jean-Pierre Abastado, F. Godeau, and Philippe Kourilsky

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Dissociation of the peptide/MHC class I complex: pH dependence and effect of endogenous peptides on the activation energy, David M. Ojcius, L. Gapin, and Philippe Kourilsky

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Real-time measurement of antigenic peptide binding to empty and preloaded single-chain MHC class I molecules, David M. Ojcius, Francois Godeau, Jean-Pierre Abastado, Jean-Laurent Casanova, and Philippe Kourilsky

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A Common Mechanism for Influenza Virus Fusion Activity and Inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, Arsélio Pato de Carvalho, and Maria Conceição Pedroso De Lima

Fusion kinetics of influenza virus: Differential pH requirements for fusion and inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Simian immunodeficiency virus (SIV(mac)251) membrane lipid mixing with human CD4+ and CD4- cell lines in vitro does not necessarily result in internalization of the viral core proteins and productive infection, L. Stamatatos and Nejat Düzgüneş

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Distribution of perforin-containing cells in normal and pregnant mice, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

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Perforin-containing cells during spontaneous abortion, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

Submissions from 1992

Targeted drug delivery., Nejat Düzgüneş

Liposome targeting to HIV-infected cells via recombinant soluble CD4 and CD4-IgG (immunoadhesin), Nejat Düzgüneş, Diana Flasher, S. Chamow, A. Ashkenazi, P. Dazin, and Krystyna Konopka

CD4-Mediated targeting of liposomes to HIV-infected cells, Nejat Düzgüneş, Diana Flasher, Krystyna Konopka, and S. Chamow

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Fusion activity and inactivation of influenza virus: Kinetics of low pH-induced fusion with cultured cells, Nejat Düzgüneş, Maria C. Pedroso de Lima, L. Stamatatos, D. Flasher, D. R. Alford, Daniel S. Friend, and S. Nir

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Membrane destabilization by N-terminal peptides of viral envelope proteins, Nejat Düzgüneş and Sergei A. Shavnin

Fusion activity of influenza and immunodeficiency viruses, Nejat Düzgüneş, L. Stamatatos, C. E. Larsen, Maria C. Pedroso de Lima, Dennis R. Alford, Krystyna Konopka, K-D. Lee, Elizabeth Pretzer, João Ramalho-Santos, Diana Flasher, and Shlomo Nir

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Purification and ligand binding of a soluble class I MHC molecule consisting of the first three domains of H-2Kd fused to b2-microglobulin expressed in the baculovirus/insect cell system, Francois Godeau, Immanuel F. Luescher, David M. Ojcius, Cecile Saucier, Estelle Mottez, Lucien Cabanie, and Philippe Kourilsky

Resistance of effector cells to perforin-mediated cytolysis, M. Fatima M. Horta, David M. Ojcius, and John Ding-E Young

Killer and target: A tale of two cells, S. V. Joag, David M. Ojcius, and John Ding-E Young

Mechanisms of inhibition of HIV-1 infectivity by anionic liposomes, Krystyna Konopka, C. E. Larsen, and Nejat Düzgüneş

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Efficacies of liposome-encapsulated streptomycin and ciprofloxacin against Mycobacterium avium-M. intracellulare complex infections in human peripheral blood monocyte/macrophages, S. Majumdar, Diana L. Flasher, Daniel S. Friend, P. Nassos, D. Yajko, W. K. Hadley, and Nejat Düzgüneş

Peptide binding to MHC class I proteins measured with a novel fluorescent technique, David M. Ojcius, Jean-Pierre Abastado, F. Godeau, and Philippe Kourilsky

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Channel forming activity of the perforin N-terminus and an a-helical region homologous with complement C9, P. M. Persechini, David M. Ojcius, S. C. Adeodato, Paulo C. Notaroberto, C. B. Daniel, and John Ding-E. Young

Interaction of simian immunodeficiency virus with CD4+ and CD4- cells: Envelope fusion, p27 entry and infectivity, L. Stamatatos and Nejat Düzgüneş

Large granular lymphocyte, A. Zychlinsky, David M. Ojcius, and John Ding-E Young

Submissions from 1991

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Activity of free and liposome encapsulated streptomycin against mycobacterium avium complex (MAC) inside peritoneal macrophages, D. Ashtekar, Nejat Düzgüneş, and P. R.J. Gangadharam

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Phospholipid studies of marine organisms: 26. Interactions of some marine sterols with 1-stearoyl-2-oleoyl phosphatidylcholine (SOPC) in model membranes, Meilleko C. Dai, Huong Bich Chiche, Nejat Düzgüneş, Eser Ayanoglu, and Carl Djerassi

Fusion of influenza and Sendai viruses with cultured cells, Nejat Düzgüneş, Maria Pedroso de Lima, L. Stamatatos, Diana Flasher, Daniel S. Friend, Dennis Alford, K. Klappe, Dick Hoekstra, and Shlomo Nir

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Chemotherapeutic potential of free and liposome encapsulated streptomycin against experimental mycobacterium avium complex infections in beige mice, Pattisapu R.J. Gangadharam, Dilip A. Ashtekar, Naheed Ghori, Jayne A. Goldstein, Robert J. Debs, and Nejat Düzgüneş

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Cell death mechanisms and the immune system, Pierre Golstein, David M. Ojcius, and John Ding-E. Young

Cardiolipin liposomes specifically inhibit HIV-1 infectivity, Krystyna Konopka, B. R. Davis, C. E. Larsen, and Nejat Düzgüneş

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Enhancement of human immunodeficiency virus type 1 infection by cationic liposomes: The role of CD4, serum and liposome-cell interactions, Krystyna Konopka, L. L. Stamatatos, C. E. Larsen, B. R. Davis, and Nejat Düzgüneş

Fusion of HIV-1 with liposomes and erythrocyte ghosts, C. E. Larsen, Dennis R. Alford, Shlomo Nir, M. Jennings, K-D. Lee, and Nejat Düzgüneş

Kinetics of HIV-1 fusion with liposomes and erythrocyte ghosts, C. E. Larsen, Shlomo Nir, Dennis R. Alford, M. Jennings, K-D. Lee, and Nejat Düzgüneş

Lymphocyte-mediated cytotoxicity, David M. Ojcius, Z. A. Cohn, and John Ding-E Young

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Cytoplasts from cytotoxic T lymphocytes are resistant to perforin-mediated lysis, David M. Ojcius, Shibo Jiang, Pedro M. Persechini, Patricia A. Detmers, and John Ding-E. Young

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Plasma membrane-associated proteins with the ability to partially inhibit perforin-mediated lysis, David M. Ojcius, Sylviane Muller, Cynthia S. Hasselkus-Light, John Ding-E. Young, and Shibo Jiang

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Cytolytic and ion channel forming properties of the N-terminus of lymphocyte perforin, David M. Ojcius, Pedro M. Persechini, Li-Mou Zheng, Paulo C. Notaroberto, Sandro C. Adeodato, and John Ding-E. Young

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Cytolytic peptides and proteins: Is there a common structural motif?, David M. Ojcius and John Ding-E. Young

Subcellular localization of perforin and serine esterase in lymphokine-activated killer (LAK) cells and cytotoxic T cells by immunogold labelling, David M. Ojcius, L. M. Zheng, E. C. Sphicas, A. Zychilinsky, and John Ding-E. Young

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Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes, David M. Ojcius, Arturo Zychlinsky, Li-Mou Zheng, and John Ding-E. Young

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Fusion of Sendai virus with human HL-60 and CEM cells: different kinetics of fusion for two isolates, Maria C. Pedroso de Lima, Shlomo Nir, Diana L. Flasher, Karin Klappe, Dick Hoekstra, and Nejat Düzgüneş

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Expression of lymphocyte perforin in the mouse uterus during pregnancy, Li-Mou Zheng, Chau-Ching Liu, David M. Ojcius, and John Ding-E. Young

Immunogold labelling of perforin and serine esterases in granulated metrial gland cells, Li-Mou Zheng, David M. Ojcius, Chau-Ching Liu, M. D. Kramer, M. M. Simon, E. L. Parr, and John Ding-E. Young

Role of granulated metrial gland cells in the immunology of pregnancy, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

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Extracellular ATP as a trigger for apoptosis or programmed cell death, Li-Mou Zheng, Arturo Zychlinsky, Chau-Ching Liu, David M. Ojcius, and John Ding-E. Young

Submissions from 1990

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Isolation and characterization of the gene encoding the muscle-specific isozyme of human phosphoglycerate mutase

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Cholesterol Interactions with Tetracosenoic Acid Phospholipids in Model Cell Membranes: Role of the Double-Bond Position, Eser Ayanoglu, Bich Huong Chiche, Mark Beatty, Carl Djerassi, and Nejat Düzgüneş

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In situ mapping of the muscle-specific form of phosphoglycerate mutase gene to human chromosome 7p12-7p13, Judit Castella-Escola, M. G. Mattei, David M. Ojcius, E. Passage, C. Valentin, and M. Cohen-Solal

Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor, Robert J. Debs, L. P. Freedman, S. Edmunds, K. L. Gaensler, Nejat Düzgüneş, and K. R. Yamamoto

Immunomodulatory and Toxic Effects of Free and Liposome-encapsulated Tumor Necrosis Factor a in Rats1, Robert J. Debs, Henry J. Fuchs, Ramila Philip, Elisa N. Brunette, Nejat Düzgüneş, Judd E. Shellito, Denny Liggitt, and John R. Patton

HIV-1 blocks monocyte-mediated lysis of HIV-infected cells: Role of the HIV envelope protein, Robert J. Debs, John Krowka, Elisa N. Brunette, Daniel Stites, Ramila Philip, and Nejat Düzgüneş

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Monocyte-Mediated Lysis of HIV-Infected Tumor Cells, Robert J. Debs, John Krowka, Daniel Stites, Elisa N. Brunette, Nejat Düzgüneş, and Ramila Philip

Molecular control of vesicle aggregation and membrane fusion: Hypotheses on bile vesicles, Nejat Düzgüneş

Developments in liposome-mediated chemotherapy and immunotherapy of HIV and Mycobacterium avium complex infections, Nejat Düzgüneş, Krystyna Konopka, C. Larsen, Diana Flasher, John Krowka, Daniel Stites, B. Davis, D. Ashtekar, Pattisapu Gangadharam, and Robert Debs

Fusion of immunodeficiency, influenza and Sendai viruses with liposomes and cultured cells, Nejat Düzgüneş, C. Larsen, Maria C. Pedroso de Lima, Dennis Alford, Diana Flasher, L. Young, T. McGraw, M. Jennings, K. Klappe, Dick Hoekstra, and Shlomo Nir

Development of a nucleoplasmic reticulum in CV1 cells following incorporation of cationic DOTMA liposomes, Daniel S. Friend, Robert Debs, L. Freedman, Nejat Düzgüneş, and K. Yamamoto

Interaction between DOTMA liposomes, CV1 and U937 cells, and their isolated nuclei, Daniel S. Friend, Robert J. Debs, and Nejat Düzgüneş

Chemotherapeutic assessment of free and liposome-encapsulated streptomycin against Mycobacterium avium complex infections in beige mice, Pattisapu R. J. Gangadharam, N. Ghori, D. Ashtekar, Nejat Düzgüneş, and Robert Debs

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Purification of a membrane-associated serine esterase from murine cytotoxic T lymphocytes by a single reverse phase column, Shibo Jiang, Cynthia S. Hasselkus-Light, David M. Ojcius, and John Ding-E. Young

Resistance of cytolytic lymphocytes to perforin-mediated killing: Inhibition of perforin binding activity by surface membrane proteins, Shibo Jiang, David M. Ojcius, Pedro M. Persechini, and John Ding-E. Young

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Perforin binding to cells and lipid membranes determined by a simple competition assay, Shibo Jiang, David M. Ojcius, and John Ding-E. Young

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Differential effects of free and liposome encapsulated amikacin on the survival of Mycobacterium avium complex in mouse peritoneal macrophages, L. Kesavalu, Jayne A. Goldstein, Robert J. Debs, Nejat Düzgüneş, and Pattisapu R.J. Gangadharam

Inhibition and enhancement of HIV-1 infectivity by liposomes, Krystyna Konopka, B. R. Davis, C. E. Larsen, Dennis R. Alford, Robert J. Debs, and Nejat Düzgüneş

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Liposomes modulate human immunodeficiency virus infectivity, Krystyna Konopka, B. R. Davis, C. E. Larsen, D. R. Alford, Robert J. Debs, and Nejat Düzgüneş