A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 1998

Enhancement of clarithromycin's water solubility via cyclodextrin complexation and efficacy study against Mycobacterium avium complex, Isam Ismail Salem and Nejat Düzgüneş

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Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides, Sérgio Simões, Vladimir Slepushkin, R. Caspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Delivery of antisense oligonucleotides and ribozymes mediated by pH-sensitive liposomes enhances their anti-HIV effect, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cellular uptake profile for zinc monoglycerolate (ZMG) in immune and gastric cell lines determined by fluorescence photomicrography and inductively coupled plasma mass spectrometry (ICP-MS), Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1997

Inhibition of HIV-1 replication by protease inhibitors, antisense oligonucleotides, and therapeutic genes delivered in liposomes, Nejat Düzgüneş, Krystyna Konopka, Elizabeth Pretzer, Vladimir A. Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, and John J. Rossi

Liposome-mediated delivery of antiviral drugs to HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Krystyna Konopka, Vladimir Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, E. De Clercq, and John J. Rossi

Gene delivery by anionic complexes of transferrin/cationic lipid/DNA., Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusogenic peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

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Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity, Laurent Gapin, Jean-Pierre Cabaniols, Ricardo Cibotti, David M. Ojcius, Philippe Kourilsky, and Jean M. Kanellopoulos

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Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells, Cesar Gutiérrez-Martín, David M. Ojcius, Ru-Ching Hsia, Raymond Hellio, Patrik M. Bavoil, and Alice Dautry-Varsat

Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John J. Rossi, and Nan S. Lee

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Cationic liposome-mediated expression of HIV-regulated luciferase and diphtheria toxin a genes in HeLa cells infected with or expressing HIV, Krystyna Konopka, Gail S. Harrison, Philip L. Felgner, and Nejat Düzgüneş

Inhibition of HIV infection by secretory leukocyte protease inhibitor, Krystyna Konopka, Nancy R. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

Lymphocyte-mediated cytotoxicity, David M. Ojcius, Z. A. Cohn, and John Ding-E Young

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Distribution of endosomal, lysosomal and MHC markers in a monocytic cell line infected with Chlamydia psittaci, David M. Ojcius, Raymond Hellio, and Alice Dautry-Varsat

Interaction of cationic liposomes with cells: Effect of several factors on liposome-cell fusion, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Inhibition of human immunodeficiency virus type-1 replication in macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana L. Flasher, and Nejat Düzgüneş

Effect of recombinant secretory leukocyte protease inhibitor on HIV infection in human macrophages, Nancy Shine, Krystyna Konopka, and Nejat Düzgüneş

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The anti-HIV-1 activity associated with saliva, Nancy R. Shine, Krystyna Konopka, and Nejat Düzgüneş

Effect of recombinant secretory leukocyte protease inhibitor on hiv infection in human macrophages, Nancy R. Shine, Krystyna Konppka, and Nejat Düzgüneş

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Fusogenic liposomes in gene therapy: Design of novel non-viral systems for intracellular gene delivery, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Receptor ligand-mediated lipid-based gene delivery into T-lymphocytes, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides, Sérgio Simoes, Vladimir Slepushkin, R. Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Transfection of human monocyte-derived macrophages by transferrin-cationic lipid-DNA complexes, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Transfection of human blood monocyte-derived macrophages by transferrin-cationic lipid-DNA complexes, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzert, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo, Vladimir A. Slepushkin, Sérgio Simões, Paul Dazin, Mary S. Newman, Luke S. Guo, Maria C. Pedroso De Lima, and Nejat Düzgüneş

Submissions from 1996

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Dynorphin-phospholipid membrane interactions: Role of phospholipid head-group and cholesterol, Dennis R. Alford, V. Renugopalakrishnan, and Nejat Düzgüneş

Cell suicide in health and disease, Richard C. Duke, David M. Ojcius, and John Ding-E. Young

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Treatment of intracellular Mycobacterium avium complex infection by free and liposome-encapsulated sparfloxacin, Nejat Düzgüneş, Diana L. Flasher, M. Venkata Reddy, Julieta Luna-Herrera, and Pattisapu R.J. Gangadharam

Sparfloxacin therapy of multidrug-resistant Mycobacterium tuberculosis infection in macrophages, Nejat Düzgüneş, M. V. Reddy, Diana Flasher, Julieta Luna-Herrera, and Pattisapu R. J. Gangadharam

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Introduction: novel specific immunity functioning alongside classical specific immunity, G. Gachelin, I. Apostolou, and David M. Ojcius

HIV-regulated luciferase and diphtheria toxin A fragment genes are expressed specifically in HeLa cells after transfection by cationic liposomes, Krystyna Konopka, G. Harrison, Philip Felgner, and Nejat Düzgüneş

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Human immunodeficiency virus type-1 (HIV-1) infection increases the sensitivity of macrophages and THP-1 cells to cytotoxicity by cationic liposomes, Krystyna Konopka, Elizabeth Pretzer, Philip L. Felgner, and Nejat Düzgüneş

Delivery of anti-HIV-1 ribozyme into infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Vladimir Slepushkin, and Nejat Düzgüneş

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Presentation of antigens derived from microorganisms residing in host-cell vacuoles, David M. Ojcius, Gabriel Gachelin, and Alice Dautry-Varsat

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Immunology and the confocal microscope, David M. Ojcius, F. Niedergang, A. Subtil, Raymond Hellio, and Alice Dautry-Varsat

Interaction of cationic liposomes with cells: Insights into the mechanisms of intracellular gene transfer, Pedro Pires, Henrique Faneca, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

A novel, highly potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor (UIC-94-003), Elizabeth Pretzer, Arun Ghosh, and Nejat Düzgüneş

Enhancement of the anti-HIV effect of antisense oligonucleotides by delivery in pH-sensitive liposomes, Vladimir A. Slepushkin, Elizabeth Pretzer, Sérgio Simões, Gerhard Steffan, Diana Flasher, and Nejat Düzgüneş

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Targeting of liposomes to HIV-1-infected cells by peptides derived from the CD4 receptor, Vladimir A. Slepushkin, Isam Ismail Salem, Sergei M. Andreev, Paul Dazin, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides and antiviral genes, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, Elizabeth Pretzer, Gerhard Steffan, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Sterically stabilized pH-sensitive liposomes: Mechanisms of intracellular delivery, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, Maria C. Pedroso de Lima, and Nejat Düzgüneş

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High incidence of Coxiella burnetii markers in a rural population in France, Monique Thibon, Veronique Villiers, Philippe Souque, Alice Dautry-Varsat, Regis Duquesnel, and David M. Ojcius

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Interleukin-10 inhibits tumor metastasis through an NK-cell dependent mechanism, Li-Mou Zheng, David M. Ojcius, F. Garaud, C. Roth, E. Maxwell, Z. Li, H. Rong, J. Chen, X. Y. Wang, J. J. Catino, and I. King

Submissions from 1995

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Liposome-mediated therapy of human immunodeficiency virus type-1 and mycobacterium infections, Nejat Düzgüneş, Diana L. Flasher, Elizabeth Pretzer, Krystyna Konopka, Vladimir A. Slepushkin, Gerhard Steffan, Isam I. Salem, M. Venkata Reddy, and Pattisapu R.J. Gangadharam

Liposome-encapsulated sparfloxacin, paromomycin, ciprofloxacin and clarithromycin for the therapy of Mycobacterium avium complex and Mycobacterium tuberculosis in macrophages, Nejat Düzgüneş, Diana Flasher, M. V. Reddy, Julieta Luna-Herrera, Isam I. Salem, and Pattisapu R. J. Gangadharam

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Therapy of Mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes, Pattisapu R.J. Gangadharam, D. R. Ashtekar, Diana L. Flasher, and Nejat Düzgüneş

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A monoclonal antibody to the gp120-CD4 complex has differential effects on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, F. Celada, and Nejat Düzgüneş

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Differential effects of a hydrophobic tripeptide on human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, and Nejat Düzgüneş

Infected macrophages and differentiated chronically infected THP-1HIV-1IIIB cells are more sensitive to cytotoxic effects of cationic liposomes than uninfected cells, Krystyna Konopka, Elizabeth Pretzer, Philip Felgner, and Nejat Düzgüneş

Cationic liposome-mediated delivery of anti-HIV-1 ribozyme to chronically infected cells, Krystyna Konopka, John J. Rossi, Philip Felgner, and Nejat Düzgüneş

Les mille et une ruses des microbes intracellulaires, David M. Ojcius and Alice Dautry-Varsat

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pH and calcium dependence of hemolysis due to Rickettsia prowazekii: comparison with phospholipase activity, David M. Ojcius, M. Thibon, C. Mounier, and Alice Dautry-Varsat

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Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus, Maria C. Pedroso de Lima, João Ramalho-Santos, Diana L. Flasher, Vladimir A. Slepushkin, Shlomo Nir, and Nejat Düzgüneş

Inhibition of HIV-1 infection of macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana Flasher, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability as novel delivery vehicles for anti-HIV and anti-cancer drugs, Vladimir A. Slepushkin and Nejat Düzgüneş

Development of pH-sensitive liposomes stable in serum for delivery of anti-sense oligonucleotides, Vladimir A. Slepushkin, Diana Flasher, Elizabeth Pretzer, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability, Vladimir Slepushkin and Nejat Düzgüneş

Liposome-bound cyclodextrin sulfates: a potential antiviral drug delivery system, Gerhard Steffan, C. Henke, H.J. Galla, and Nejat Düzgüneş

Submissions from 1994

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Picosecond fluorescence spectroscopy of a single-chain class I major histocompatibility complex-encoded protein in its peptide loaded and unloaded states, Kerstin Dittes, D. Gakamsky, Elisha Haas, David M. Ojcius, Philippe Kourilsky, Israel Pecht, and Gilad Haran

Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis, Richard C. Duke, R. Z. Witter, P. B. Nash, John Ding-E. Young, and David M. Ojcius

Inhibition of phagosome-lysosome fusion by microorganisms phagocytosed by macrophages, Nejat Düzgüneş

Membrane fusion activity of simian and human immunodeficiency virus: Differential molecular requirements for membrane lipid mixing, nucleocapsid entry and cell-cell fusion, Nejat Düzgüneş, L. Stamatatos, Krystyna Konopka, F. Celada, and Elizabeth Pretzer

Targeting liposomes to cells infected with human immunodeficiency virus type 1 (HIV-1), Diana Flasher, Krystyna Konopka, S. Chamow, P. Dazin, A. Ashkenazi, Elizabeth Pretzer, and Nejat Düzgüneş

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Liposome targeting to human immunodeficiency virus type 1-infected cells via recombinant soluble CD4 and CD4 immunoadhesin (CD4-IgG), Diana Flasher, Krystyna Konopka, Steven M. Chamow, Paul Dazin, Avi Ashkenazi, Elizabeth Pretzer, and Nejat Düzgüneş

Differential effects of a monoclonal antibody to the gp120-CD4 complex on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, E. Seravalli, F. Celada, and Nejat Düzgüneş

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Role of the CDR1 of the TCR β chain in the binding to a MHC-peptide complex, Yu-Chun Lone, Maria Bellio, Ada Prochnicka-Chalufour, David M. Ojcius, Nicolas Boissel, Tom H. M. Ottenhoff, Richard D. Klausner, Jean-Pierre Abastado, and Philippe Kourilsky

Major contribution of the Vb chain to the antigen specificity of a TCR, Yu-Chun Lone, David M. Ojcius, M. Bellio, Philippe Kourilsky, and J.-P. Abastado

Major histocompatibility complex class I molecules and resistance to infection by intracellular pathogens, David M. Ojcius, Christiane Delarbre, Philippe Kourilsky, and Gabriel Gachelin

Is antigen processing guided by major histocompatibility complex molecules?, David M. Ojcius, L. Gapin, Jean M. Kanellopoulos, and Philippe Kourilsky

Role for MHC class I molecules in selecting and protecting high affinity peptides in the presence of proteases, David M. Ojcius, P. Langlade-Demoyen, Gabriel Gachelin, and Philippe Kourilsky

Role of target membrane sialic acid in the fusion activity of influenza virus, João Ramalho-Santos, Nejat Düzgüneş, Diana Flasher, Shlomo Nir, and Maria C. Pedroso de Lima

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Ly-49-independent inhibition of NK cell-mediated cytotoxicity by a soluble MHC class I molecule, Claude Roth, Philippe Kourilsky, and David M. Ojcius

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Separate metabolic pathways leading to DNA fragmentation and apoptotic nuclear chromatin condensation, D. Sun, Shibo Jiang, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

Submissions from 1993

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A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd, Jean-Pierre Abastado, David M. Ojcius, Amanda Casrouge, Patrice Yeh, Ton N. M. Schumacher, Hidde L. Ploegh, and Philippe Kourilsky

Liposome-encapsulated antiviral agents inhibit HIV-1 replication in monocyte/macrophages and a chronically infected macrophage cell line, Nejat Düzgüneş, Diana Flasher, Elizabeth Pretzer, Krystyna Konopka, and S. Chamow

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Anionic liposomes inhibit human immunodeficiency virus type 1 (HIV-1) infectivity in CD4+ A3.01 and H9 cells, Krystyna Konopka, B. R. Davis, C. E. Larsen, and Nejat Düzgüneş

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Long-Term Noncytopathic Productive Infection of the Human Monocytic Leukemia Cell Line THP-1 by Human Immunedeficiency Virus Type 1 (HIV-1IIIB), Krystyna Konopka, Elizabeth Pretzer, Barbara Plowman, and Nejat Düzgüneş

Long-term noncytopathic productive infection of the human monocytic leukemia cell line THP-1 by HIV-1IIIB, Krystyna Konopka, Elizabeth Pretzer, B. Plowman, and Nejat Düzgüneş

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Human immunodeficiency virus type 1 (HIV-1) fusion with model membranes: kinetic analysis and the role of lipid composition, pH and divalent cations, Charles E. Larsen, Shlomo Nir, Dennis R. Alford, Myra Jennings, Kyung Dall Lee, and Nejat Düzgüneş

Dissociation of the peptide-MHC class I complex limits the binding rate of exogenous peptide, David M. Ojcius, Jean-Pierre Abastado, Amanda Casrouge, E. Mottez, L. Cabanie, and Philippe Kourilsky

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Binding of alanine-substituted peptides to the MHC class I protein Kd, David M. Ojcius, Jean-Pierre Abastado, F. Godeau, and Philippe Kourilsky

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Dissociation of the peptide/MHC class I complex: pH dependence and effect of endogenous peptides on the activation energy, David M. Ojcius, L. Gapin, and Philippe Kourilsky

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Real-time measurement of antigenic peptide binding to empty and preloaded single-chain MHC class I molecules, David M. Ojcius, Francois Godeau, Jean-Pierre Abastado, Jean-Laurent Casanova, and Philippe Kourilsky

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A Common Mechanism for Influenza Virus Fusion Activity and Inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, Arsélio Pato de Carvalho, and Maria Conceição Pedroso De Lima

Fusion kinetics of influenza virus: Differential pH requirements for fusion and inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Simian immunodeficiency virus (SIV(mac)251) membrane lipid mixing with human CD4+ and CD4- cell lines in vitro does not necessarily result in internalization of the viral core proteins and productive infection, L. Stamatatos and Nejat Düzgüneş

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Distribution of perforin-containing cells in normal and pregnant mice, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

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Perforin-containing cells during spontaneous abortion, Li-Mou Zheng, David M. Ojcius, and John Ding-E. Young

Submissions from 1992

Targeted drug delivery., Nejat Düzgüneş

Liposome targeting to HIV-infected cells via recombinant soluble CD4 and CD4-IgG (immunoadhesin), Nejat Düzgüneş, Diana Flasher, S. Chamow, A. Ashkenazi, P. Dazin, and Krystyna Konopka

CD4-Mediated targeting of liposomes to HIV-infected cells, Nejat Düzgüneş, Diana Flasher, Krystyna Konopka, and S. Chamow

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Fusion activity and inactivation of influenza virus: Kinetics of low pH-induced fusion with cultured cells, Nejat Düzgüneş, Maria C. Pedroso de Lima, L. Stamatatos, D. Flasher, D. R. Alford, Daniel S. Friend, and S. Nir

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Membrane destabilization by N-terminal peptides of viral envelope proteins, Nejat Düzgüneş and Sergei A. Shavnin

Fusion activity of influenza and immunodeficiency viruses, Nejat Düzgüneş, L. Stamatatos, C. E. Larsen, Maria C. Pedroso de Lima, Dennis R. Alford, Krystyna Konopka, K-D. Lee, Elizabeth Pretzer, João Ramalho-Santos, Diana Flasher, and Shlomo Nir

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Purification and ligand binding of a soluble class I MHC molecule consisting of the first three domains of H-2Kd fused to b2-microglobulin expressed in the baculovirus/insect cell system, Francois Godeau, Immanuel F. Luescher, David M. Ojcius, Cecile Saucier, Estelle Mottez, Lucien Cabanie, and Philippe Kourilsky

Resistance of effector cells to perforin-mediated cytolysis, M. Fatima M. Horta, David M. Ojcius, and John Ding-E Young