ORCiD
Nejat Düzgüneş: 0000-0001-6159-1391
Department
Biomedical Sciences
Document Type
Article
Publication Title
Antiviral Chemistry and Chemotherapy
ISSN
0956-3202
Volume
4
Issue
3
DOI
10.1177/095632029300400308
First Page
179
Last Page
187
Publication Date
1-1-1993
Abstract
Immunodeficiency viruses undergo fusion with liposomes containing anionic phospholipids (Larsen et al., 1990). We have investigated the effect of liposomes composed of cardiolipin, phosphatidylserine or phosphatidylinositol, on the infectivity of three strains of HIV-1 in A3.01 and H9 cells, measured by p24 (gag) production in the medium. The infectivity of HIV-1 in A3.01 or H9 cells was inhibited by the presence of cardiolipin liposomes during a 2 h infection period, with IC50's of 23.0, 4.8, and 5.0 μM phospholipid, respectively, for the different strains. Liposomes composed of phosphatidylserine or phosphatidylinositol were ineffective under similar conditions. However, prolonged pre-incubation of the virus with these liposomes also inhibited infectivity. Inhibition of virus binding to cells could not account for the inhibition of infectivity. We propose that the fusion products of HIV-1 and anionic liposomes are impaired in their ability to fuse with the plasma membrane.
Recommended Citation
Konopka, K.,
Davis, B. R.,
Larsen, C. E.,
&
Düzgüneş, N.
(1993).
Anionic liposomes inhibit human immunodeficiency virus type 1 (HIV-1) infectivity in CD4+ A3.01 and H9 cells.
Antiviral Chemistry and Chemotherapy, 4(3), 179–187.
DOI: 10.1177/095632029300400308
https://scholarlycommons.pacific.edu/dugoni-facarticles/535
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