A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 1999

Highly efficient binding of cationic liposomes to Porphyromonas gingivalis, K. Farzaneh, A. Alijanian, T. Bramanti, and Nejat Düzgüneş

Antiviral activity of UIC-94-003, a novel inhibitor of the human immunodeficiency virus type-1 protease, Arun K. Ghosh, Elizabeth Pretzer, Hanna Cho, Khaja A. Hussain, W. Cho, D. E. Walters, and Nejat Düzgüneş

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells does not correlate with expression of surface proteins CD4, CD26 and CCR5, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

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Anti-HIV activity of amphotericin B-cholesteryl sulfate colloidal dispersion in vitro, Krystyna Konopka, Luke S.S. Guo, and Nejat Düzgüneş

Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Transferrin lipoplexes for gene therapy of HIV: Rev-binding aptamer and CMV promoter as decoys, Krystyna Konopka, Nan S. Lee, L. Scherer, John J. Rossi, and Nejat Düzgüneş

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Secretory leukocyte protease inhibitor (SLPI): oxidation of SLPI does not explain its variable anti-HIV activity, Krystyna Konopka, N. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

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Caspase-dependent apoptosis during infection with Cryptosporidium parvum, David M. Ojcius, Jean-Luc Perfettini, Alain Bonnin, and Fabrice Laurent

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Gene delivery mediated by cationic liposomes: From biophysical aspects to enhancement of transfection, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir A. Slepushkin, and Nejat Düzgüneş

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Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells, Pedro Pires, Sérgio Simões, Shlomo Nir, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso De Lima

Mechanisms of cellular internalization of lipoplexes: A fluorescence and electron microscopy study, Pedro Pires, Sérgio Simões, B. Plowman, Nejat Düzgüneş, and Maria C. Pedroso de Lima

On the enhancing effect of transfection by proteins associated to lipoplexes, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy, Sérgio Simões, Pedro Pires, Nejat Düzgüneş, and Maria C. Pedroso De Lima

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Successful transfection of lymphocytes by ternary lipoplexes, Sérgio Simões, Vladimir Slepushkin, R. Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Paul Dazin, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

Serum-resistant transferrin lipoplexes, C. Tros and Nejat Düzgüneş

Efficient gene delivery to hepatocytes by transferrin-lipoplexes in the presence of serum, M. Conchita Tros de Ilarduya and Nejat Düzgüneş

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Zinc monoglycerolate (ZMG) and zinc salt cellular uptake profile in vitro determined by plasma mass spectrometry, Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1998

Anti-peptide antibodies inhibit HIV-1 induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

History lesson, Nejat Düzgüneş

Liposome-mediated delivery of antiviral drugs, antisense oligonucleotides, and therapeutic genes into HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Vladimir Slepushkin, Krystyna Konopka, Diana Flasher, Sérgio Simões, V. P. Antao, M. L. Collins, E. De Clercq, M. S. Newman, L. S. Gao, P. Dazin, G. S. Harrison, Nan S. Lee, John J. Rossi, and Maria C. Pedroso de Lima

Gene delivery by net negatively charged complexes of cationic liposomes, DNA and transferrin or pH-sensitive peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Transfection of epithelial and lymphocytic cell lines and monocyte/macrophages by net negatively charged transferrin/cationic lipid/DNA complexes, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

pH Sensitive Liposomes: A Novel Approach in Antibiotic Delivery, Pattisapu R. J. Gangadharam, Diana Flasher, M. V. Reddy, and Nejat Düzgüneş

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Functional gene transfer from intracellular bacteria to mammalian host cells, Catherine Grillot-Courvalin, Sylvie Goussard, Francois Huetz, David M. Ojcius, and Patrice Courvalin

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Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John Rossi, and Nan Sook Lee

Incorporation of amphotericin B into stealth liposomes or colloidal dispersions diminishes its in vitro anti-HIV activity, Krystyna Konopka, Luke S. S. Guo, and Vladimir Slepushkin

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Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Piotr Swiderski, Vladimir A. Slepushkin, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Activities of Free and Liposome-Encapsulated Sparfloxacin against Intracellular Drug-Susceptible and Multiple Drug Resistant (MDR) Tubercle Bacilli, Julieta Luna-Herrera, M. V. Reddy, Diana Flasher, Nejat Düzgüneş, and Pattisapu R. J. Gangadharam

A comparative study of fluorescent probes for monitoring virus fusion kinetics, Isabel Nunes-Correia, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells, David M. Ojcius, Yolanda Bravo de Alba, Jean M. Kanellopoulos, Ray A. Hawkins, Kathy A. Kelly, Roger G. Rank, and Alice Dautry-Varsat

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Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia: NMR studies of living cells, David M. Ojcius, H. Degani, Joel Mispelter, and Alice Dautry-Varsat

Pore-forming proteins, David M. Ojcius, Chau-Ching Liu, and John Ding-E. Young

Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci, David M. Ojcius, Philippe Souque, Jean-Luc Perfettini, and Alice Dautry-Varsat

Development of novel non-viral gene transfer vectors, Maria C. Pedroso de Lima, Rogério Gaspar, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection, Maria C. Pedroso de Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir Slepushkin, and Nejat Düzgüneş

Role of lipid mixing in the physico-chemical properties of cationic liposome/DNA complexes and in their interaction with cells, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Insights into the interaction of lipoplex-mediated gene delivery: Fusion with or destabilization of the plasma membrane?, Pedro Pires, Sérgio Simões, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration. In: Copper and Zinc in Inflammatory and Degenerative Diseases, Kim D. Rainsford and Benjamin David Zeitlin

Enhancement of clarithromycin's water solubility via cyclodextrin complexation and efficacy study against Mycobacterium avium complex, Isam Ismail Salem and Nejat Düzgüneş

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Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides, Sérgio Simões, Vladimir Slepushkin, R. Caspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Delivery of antisense oligonucleotides and ribozymes mediated by pH-sensitive liposomes enhances their anti-HIV effect, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cellular uptake profile for zinc monoglycerolate (ZMG) in immune and gastric cell lines determined by fluorescence photomicrography and inductively coupled plasma mass spectrometry (ICP-MS), Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1997

Inhibition of HIV-1 replication by protease inhibitors, antisense oligonucleotides, and therapeutic genes delivered in liposomes, Nejat Düzgüneş, Krystyna Konopka, Elizabeth Pretzer, Vladimir A. Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, and John J. Rossi

Liposome-mediated delivery of antiviral drugs to HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Krystyna Konopka, Vladimir Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, E. De Clercq, and John J. Rossi

Gene delivery by anionic complexes of transferrin/cationic lipid/DNA., Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusogenic peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

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Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity, Laurent Gapin, Jean-Pierre Cabaniols, Ricardo Cibotti, David M. Ojcius, Philippe Kourilsky, and Jean M. Kanellopoulos

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Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells, Cesar Gutiérrez-Martín, David M. Ojcius, Ru-Ching Hsia, Raymond Hellio, Patrik M. Bavoil, and Alice Dautry-Varsat

Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John J. Rossi, and Nan S. Lee

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Cationic liposome-mediated expression of HIV-regulated luciferase and diphtheria toxin a genes in HeLa cells infected with or expressing HIV, Krystyna Konopka, Gail S. Harrison, Philip L. Felgner, and Nejat Düzgüneş

Inhibition of HIV infection by secretory leukocyte protease inhibitor, Krystyna Konopka, Nancy R. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

Lymphocyte-mediated cytotoxicity, David M. Ojcius, Z. A. Cohn, and John Ding-E Young

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Distribution of endosomal, lysosomal and MHC markers in a monocytic cell line infected with Chlamydia psittaci, David M. Ojcius, Raymond Hellio, and Alice Dautry-Varsat

Interaction of cationic liposomes with cells: Effect of several factors on liposome-cell fusion, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Inhibition of human immunodeficiency virus type-1 replication in macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana L. Flasher, and Nejat Düzgüneş

Effect of recombinant secretory leukocyte protease inhibitor on HIV infection in human macrophages, Nancy Shine, Krystyna Konopka, and Nejat Düzgüneş

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The anti-HIV-1 activity associated with saliva, Nancy R. Shine, Krystyna Konopka, and Nejat Düzgüneş

Effect of recombinant secretory leukocyte protease inhibitor on hiv infection in human macrophages, Nancy R. Shine, Krystyna Konppka, and Nejat Düzgüneş

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Fusogenic liposomes in gene therapy: Design of novel non-viral systems for intracellular gene delivery, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Receptor ligand-mediated lipid-based gene delivery into T-lymphocytes, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides, Sérgio Simoes, Vladimir Slepushkin, R. Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Transfection of human monocyte-derived macrophages by transferrin-cationic lipid-DNA complexes, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Transfection of human blood monocyte-derived macrophages by transferrin-cationic lipid-DNA complexes, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzert, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo, Vladimir A. Slepushkin, Sérgio Simões, Paul Dazin, Mary S. Newman, Luke S. Guo, Maria C. Pedroso De Lima, and Nejat Düzgüneş

Submissions from 1996

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Dynorphin-phospholipid membrane interactions: Role of phospholipid head-group and cholesterol, Dennis R. Alford, V. Renugopalakrishnan, and Nejat Düzgüneş

Cell suicide in health and disease, Richard C. Duke, David M. Ojcius, and John Ding-E. Young

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Treatment of intracellular Mycobacterium avium complex infection by free and liposome-encapsulated sparfloxacin, Nejat Düzgüneş, Diana L. Flasher, M. Venkata Reddy, Julieta Luna-Herrera, and Pattisapu R.J. Gangadharam

Sparfloxacin therapy of multidrug-resistant Mycobacterium tuberculosis infection in macrophages, Nejat Düzgüneş, M. V. Reddy, Diana Flasher, Julieta Luna-Herrera, and Pattisapu R. J. Gangadharam

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Introduction: novel specific immunity functioning alongside classical specific immunity, G. Gachelin, I. Apostolou, and David M. Ojcius

HIV-regulated luciferase and diphtheria toxin A fragment genes are expressed specifically in HeLa cells after transfection by cationic liposomes, Krystyna Konopka, G. Harrison, Philip Felgner, and Nejat Düzgüneş

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Human immunodeficiency virus type-1 (HIV-1) infection increases the sensitivity of macrophages and THP-1 cells to cytotoxicity by cationic liposomes, Krystyna Konopka, Elizabeth Pretzer, Philip L. Felgner, and Nejat Düzgüneş

Delivery of anti-HIV-1 ribozyme into infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Vladimir Slepushkin, and Nejat Düzgüneş

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Presentation of antigens derived from microorganisms residing in host-cell vacuoles, David M. Ojcius, Gabriel Gachelin, and Alice Dautry-Varsat

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Immunology and the confocal microscope, David M. Ojcius, F. Niedergang, A. Subtil, Raymond Hellio, and Alice Dautry-Varsat

Interaction of cationic liposomes with cells: Insights into the mechanisms of intracellular gene transfer, Pedro Pires, Henrique Faneca, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

A novel, highly potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor (UIC-94-003), Elizabeth Pretzer, Arun Ghosh, and Nejat Düzgüneş

Enhancement of the anti-HIV effect of antisense oligonucleotides by delivery in pH-sensitive liposomes, Vladimir A. Slepushkin, Elizabeth Pretzer, Sérgio Simões, Gerhard Steffan, Diana Flasher, and Nejat Düzgüneş

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Targeting of liposomes to HIV-1-infected cells by peptides derived from the CD4 receptor, Vladimir A. Slepushkin, Isam Ismail Salem, Sergei M. Andreev, Paul Dazin, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides and antiviral genes, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, Elizabeth Pretzer, Gerhard Steffan, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Sterically stabilized pH-sensitive liposomes: Mechanisms of intracellular delivery, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, Maria C. Pedroso de Lima, and Nejat Düzgüneş

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High incidence of Coxiella burnetii markers in a rural population in France, Monique Thibon, Veronique Villiers, Philippe Souque, Alice Dautry-Varsat, Regis Duquesnel, and David M. Ojcius

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Interleukin-10 inhibits tumor metastasis through an NK-cell dependent mechanism, Li-Mou Zheng, David M. Ojcius, F. Garaud, C. Roth, E. Maxwell, Z. Li, H. Rong, J. Chen, X. Y. Wang, J. J. Catino, and I. King

Submissions from 1995

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Liposome-mediated therapy of human immunodeficiency virus type-1 and mycobacterium infections, Nejat Düzgüneş, Diana L. Flasher, Elizabeth Pretzer, Krystyna Konopka, Vladimir A. Slepushkin, Gerhard Steffan, Isam I. Salem, M. Venkata Reddy, and Pattisapu R.J. Gangadharam

Liposome-encapsulated sparfloxacin, paromomycin, ciprofloxacin and clarithromycin for the therapy of Mycobacterium avium complex and Mycobacterium tuberculosis in macrophages, Nejat Düzgüneş, Diana Flasher, M. V. Reddy, Julieta Luna-Herrera, Isam I. Salem, and Pattisapu R. J. Gangadharam

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Therapy of Mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes, Pattisapu R.J. Gangadharam, D. R. Ashtekar, Diana L. Flasher, and Nejat Düzgüneş

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A monoclonal antibody to the gp120-CD4 complex has differential effects on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, F. Celada, and Nejat Düzgüneş

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Differential effects of a hydrophobic tripeptide on human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, and Nejat Düzgüneş

Infected macrophages and differentiated chronically infected THP-1HIV-1IIIB cells are more sensitive to cytotoxic effects of cationic liposomes than uninfected cells, Krystyna Konopka, Elizabeth Pretzer, Philip Felgner, and Nejat Düzgüneş

Cationic liposome-mediated delivery of anti-HIV-1 ribozyme to chronically infected cells, Krystyna Konopka, John J. Rossi, Philip Felgner, and Nejat Düzgüneş

Les mille et une ruses des microbes intracellulaires, David M. Ojcius and Alice Dautry-Varsat

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pH and calcium dependence of hemolysis due to Rickettsia prowazekii: comparison with phospholipase activity, David M. Ojcius, M. Thibon, C. Mounier, and Alice Dautry-Varsat

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Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus, Maria C. Pedroso de Lima, João Ramalho-Santos, Diana L. Flasher, Vladimir A. Slepushkin, Shlomo Nir, and Nejat Düzgüneş