A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 2002

Treatment of hepatocellular carcinoma by asialofetuin lipoplexes carrying IL-12 plasmid, Miguel A. Arangoa, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

Enhanced gene delivery by asialofetuin-liposomes for the treatment of hepatocellular carcinoma, Miguel A. Arangoa, Cheng Qian, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

The influence of antifungal polyenes on in vitro adherence of Candida to epithelial cells, Barbara Dorocka-Bobkowska, Krystyna Konopka, and Nejat Düzgüneş

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Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease, Arun K. Ghosh, Elizabeth Pretzer, Hanna Cho, Khaja Azhar Hussain, and Nejat Düzgüneş

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Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator, Thomas Jungas, Iris Motta, Francis Duffieux, Pascale Fanen, Veronique Stoven, and David M. Ojcius

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Expression of CD4 controls the susceptibility of THP-1 cells to infection by R5 and X4 HIV type 1 isolates, Krystyna Konopka and Nejat Düzgüneş

The SV40 promoter/enhancer element in trans stimulates HIV-1 LTR-driven gene expression, Krystyna Konopka and Nejat Düzgüneş

Transfection of HeLa, HEK293 and HSC-3 cells by transferrin lipoplexes, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

Lipid-mediated gene delivery to HSC-3 and HEK293 cells in the presence of serum, A. Lim, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

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Absence of weight loss during Cryptosporidium infection in susceptible mice deficient in Fas-mediated apoptosis, Iris Motta, Mathieu Gissot, Jean M. Kanellopoulos, and David M. Ojcius

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Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability, Isabel Nunes-Correia, Ana Eulálio, Shlomo Nir, Nejat Düzgüneş, João Ramalho-Santos, and Maria C. Pedroso De Lima

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MHC and MHC-related proteins as pleiotropic signal molecules, David M. Ojcius, Christiane Delarbre, Philippe Kourilsky, and Gabriel Gachelin

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Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis), Jean-Luc Perfettini, Toni Darville, Alice Dautry-Varsat, Roger G. Rank, and David M. Ojcius

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Modulation of apoptosis during infection with Chlamydia, Jean-Luc Perfettini, Mathieu Gissot, Philippe Souque, and David M. Ojcius

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Role of Bcl-2 family members in caspase-independent apoptosis due to Chlamydia infection, Jean-Luc Perfettini, John C. Reed, Nicole Israel, Jean-Claude Martinou, Alice Dautry-Varsat, and David M. Ojcius

HSV-tk/ganciclovir-based non-viral gene therapy in human oral cancer cells, S. Saghezchi, Aaron Lee, Krystyna Konopka, and Nejat Düzgüneş

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Secretory leukocyte protease inhibitor: Inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein, Nancy R. Shine, S. C. Wang, Krystyna Konopka, E. A. Burks, Nejat Düzgüneş, and C. P. Whitman

Newly cloned secretory leukocyte protease inhibitor (SLPI) inhibits HIV-1 infection of monocytic THP-1 cells, Nancy R. Shine, Susan C. Wang, Krystyna Konopka, Elizabeth A. Burks, Nejat Düzgüneş, and Christian P. Whitman

Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles, Sérgio Simões, C. Fonseca, Henrique Faneca, Nejat Düzgüneş, and Maria C. Pedroso de Lima

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Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes, Conchita Tros De Ilarduya, M. A. Arangoa, M. J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 2001

Asialofetuin lipoplexes for enhanced transfection of hepatic cells, Miguel A. Arangoa, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

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Characterization of a monoclonal antibody reacting with antigen-4 domain of gp900 in Cryptosporidium parvum invasive stages, Alain Bonnin, David M. Ojcius, Philippe Souque, Debra A. Barnes, Patricia S. Doyle, Jiri Gut, Richard G. Nelson, Carolyn Petersen, and Jean-Francois Dubremetz

Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci, Robson Coutinho-Silva, Jean-Luc Perfettini, Pedro M. Persechini, Alice Dautry-Varsat, and David M. Ojcius

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Lipid assemblies for drug delivery, Nejat Düzgüneş

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Delivery of novel macromolecular drugs against HIV-1, Nejat Düzgüneş, Sérgio Simões, Krystyna Konopka, John J. Rossi, and Maria C. Pedroso De Lima

HIV-1 LTR- and SV40-driven gene expression is inhibited by the CMV promoter, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Secretory leukocyte protease inhibitor and HIV-1 infection of THP-1 cells, Krystyna Konopka, Nancy R. Shine, Susan C. Wang, Christian P. Whitman, and Nejat Düzgüneş

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Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

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Radical changes to chlamydial taxonomy are not necessary just yet, J. Schachter, R. S. Stephens, P. Timms, C. Kuo, Patrik M. Bavoil, S. Birkelund, J. Boman, H. Caldwell, L. A. Campbell, M. Chernesky, G. Christiansen, I. N. Clarke, C. Gaydos, J. T. Grayston, T. Hackstadt, R. Hsia, B. Kaltenboeck, M. Leinonnen, David M. Ojcius, G. McClarty, J. Orfila, R. Peeling, M. Puolakkainen, T. C. Quinn, R. G. Rank, J. Raulston, G. L. Ridgeway, P. Saikku, W. E. Stamm, D. T. Taylor-Robinson, S. P. Wang, and P. B. Wyrick

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On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes, Sérgio Simões, Vladimir Slepushkin, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Submissions from 2000

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Closing in on Chlamydia and its intracellular bag of tricks, Patrik M. Bavoil, Ru-ching Hsia, and David M. Ojcius

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Fluorescent labelling of intracellular bacteria in living host cells, Haralabia Boleti, David M. Ojcius, and Alice Dautry-Varsat

Intracellular delivery of anti-HIV agents via pH-sensitive liposomes and transferrin-lipoplexes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, Nan S. Lee, John J. Rossi, Maria C. Pedroso de Lima, and Krystyna Konopka

Superior inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides encapsulated in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Enhanced inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides delivered in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, John J. Rossi, E. De Clercq, V. P. Antao, M. L. Collins, and Maria C. Pedroso de Lima

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La notion de danger, Jean M. Kanellopoulos and David M. Ojcius

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells is not affected by treatment with heparinase, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

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Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan Sook Lee, John Rossi, and Nejat Düzgüneş

The CMV promoter inhibits HIV-1 LTR- and SV40-driven gene expression, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Therapy for oral squamous cell carcinoma using cationic lipid-DNA complexes for gene delivery, N. C. Moser, V. V. Suzara, Krystyna Konopka, and Nejat Düzgüneş

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Effect of Chlamydia trachomatis infection and subsequent TNFa secretion on apoptosis in the murine genital tract, Jean-Luc Perfettini, Toni Darville, Gabriel Gachelin, Philippe Souque, Michel Huerre, Alice Dautry-Varsat, and David M. Ojcius

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Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Efficient gene transfer by transferrin lipoplexes in the presence of serum, Conchita Tros De Ilarduya and Nejat Düzgüneş

Controlled gene delivery to cultured rat hepatocytes and adipocytes by liposomes containing transferrin, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Transfection of primary rat hepatocytes and adipocytes by transferrin lipoplexes, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 1999

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Chlamydia trachomatis, ennemi intérieur : de la biologie moléculaire aux modèles animaux, Patrik M. Bavoil, David M. Ojcius, Alice Dautry-Varsat, A. Souriau, F. Bernard, A. Rodolakis, and R.-C. Hsia

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Chlamydia infection or epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth, Haralabia Boleti, Alexandre Benmerah, David M. Ojcius, Nadine Cerf-Bensussan, and Alice Dautry-Varsat

P2Z-P2X7 receptor-mediated apoptosis of dendritic cells, Robson Coutinho-Silva, Pedro M. Persechini, R. C. Bisaggio, Jean-Luc Perfettini, A. C. T. Sa Neto, Jean M. Kanellopoulos, I. Motta, Alice Dautry-Varsat, and David M. Ojcius

Science by consensus: Why the NIH grant review system must be changed, Nejat Düzgüneş

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Mechanisms and kinetics of liposome-cell interactions, Nejat Düzgüneş and Shlomo Nir

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Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir A. Slepushkin, Krystyna Konopka, Diana Flasher, and Maria C. Pedroso De Lima

Enhanced antiviral effect of ribozymes, PMEA and antisense oligonucleotides in HIV-1-infected macrophages by delivery in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Human serum albumin enhances gene delivery by lipoplexes and confers resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Human serum albumin-lipoplexes: Enhanced gene delivery and resistance to serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Lipoplexes associated with human serum albumin or transferrin: Enhanced gene delivery to cell lines and macrophages, and resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, C. Tros, Diana Flasher, and Maria C. Pedroso de Lima

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells, E. Farge, David M. Ojcius, A. Subtil, and Alice Dautry-Varsat

Highly efficient binding of cationic liposomes to Porphyromonas gingivalis, K. Farzaneh, A. Alijanian, T. Bramanti, and Nejat Düzgüneş

Antiviral activity of UIC-94-003, a novel inhibitor of the human immunodeficiency virus type-1 protease, Arun K. Ghosh, Elizabeth Pretzer, Hanna Cho, Khaja A. Hussain, W. Cho, D. E. Walters, and Nejat Düzgüneş

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells does not correlate with expression of surface proteins CD4, CD26 and CCR5, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

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Anti-HIV activity of amphotericin B-cholesteryl sulfate colloidal dispersion in vitro, Krystyna Konopka, Luke S.S. Guo, and Nejat Düzgüneş

Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Transferrin lipoplexes for gene therapy of HIV: Rev-binding aptamer and CMV promoter as decoys, Krystyna Konopka, Nan S. Lee, L. Scherer, John J. Rossi, and Nejat Düzgüneş

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Secretory leukocyte protease inhibitor (SLPI): oxidation of SLPI does not explain its variable anti-HIV activity, Krystyna Konopka, N. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

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Caspase-dependent apoptosis during infection with Cryptosporidium parvum, David M. Ojcius, Jean-Luc Perfettini, Alain Bonnin, and Fabrice Laurent

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Gene delivery mediated by cationic liposomes: From biophysical aspects to enhancement of transfection, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir A. Slepushkin, and Nejat Düzgüneş

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Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells, Pedro Pires, Sérgio Simões, Shlomo Nir, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso De Lima

Mechanisms of cellular internalization of lipoplexes: A fluorescence and electron microscopy study, Pedro Pires, Sérgio Simões, B. Plowman, Nejat Düzgüneş, and Maria C. Pedroso de Lima

On the enhancing effect of transfection by proteins associated to lipoplexes, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy, Sérgio Simões, Pedro Pires, Nejat Düzgüneş, and Maria C. Pedroso De Lima

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Successful transfection of lymphocytes by ternary lipoplexes, Sérgio Simões, Vladimir Slepushkin, R. Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

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Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Paul Dazin, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

Serum-resistant transferrin lipoplexes, C. Tros and Nejat Düzgüneş

Efficient gene delivery to hepatocytes by transferrin-lipoplexes in the presence of serum, M. Conchita Tros de Ilarduya and Nejat Düzgüneş

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Zinc monoglycerolate (ZMG) and zinc salt cellular uptake profile in vitro determined by plasma mass spectrometry, Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1998

Anti-peptide antibodies inhibit HIV-1 induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

History lesson, Nejat Düzgüneş

Liposome-mediated delivery of antiviral drugs, antisense oligonucleotides, and therapeutic genes into HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Vladimir Slepushkin, Krystyna Konopka, Diana Flasher, Sérgio Simões, V. P. Antao, M. L. Collins, E. De Clercq, M. S. Newman, L. S. Gao, P. Dazin, G. S. Harrison, Nan S. Lee, John J. Rossi, and Maria C. Pedroso de Lima

Gene delivery by net negatively charged complexes of cationic liposomes, DNA and transferrin or pH-sensitive peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Transfection of epithelial and lymphocytic cell lines and monocyte/macrophages by net negatively charged transferrin/cationic lipid/DNA complexes, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

pH Sensitive Liposomes: A Novel Approach in Antibiotic Delivery, Pattisapu R. J. Gangadharam, Diana Flasher, M. V. Reddy, and Nejat Düzgüneş

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Functional gene transfer from intracellular bacteria to mammalian host cells, Catherine Grillot-Courvalin, Sylvie Goussard, Francois Huetz, David M. Ojcius, and Patrice Courvalin

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Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John Rossi, and Nan Sook Lee

Incorporation of amphotericin B into stealth liposomes or colloidal dispersions diminishes its in vitro anti-HIV activity, Krystyna Konopka, Luke S. S. Guo, and Vladimir Slepushkin

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Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Piotr Swiderski, Vladimir A. Slepushkin, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Activities of Free and Liposome-Encapsulated Sparfloxacin against Intracellular Drug-Susceptible and Multiple Drug Resistant (MDR) Tubercle Bacilli, Julieta Luna-Herrera, M. V. Reddy, Diana Flasher, Nejat Düzgüneş, and Pattisapu R. J. Gangadharam

A comparative study of fluorescent probes for monitoring virus fusion kinetics, Isabel Nunes-Correia, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells, David M. Ojcius, Yolanda Bravo de Alba, Jean M. Kanellopoulos, Ray A. Hawkins, Kathy A. Kelly, Roger G. Rank, and Alice Dautry-Varsat

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Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia: NMR studies of living cells, David M. Ojcius, H. Degani, Joel Mispelter, and Alice Dautry-Varsat

Pore-forming proteins, David M. Ojcius, Chau-Ching Liu, and John Ding-E. Young

Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci, David M. Ojcius, Philippe Souque, Jean-Luc Perfettini, and Alice Dautry-Varsat

Development of novel non-viral gene transfer vectors, Maria C. Pedroso de Lima, Rogério Gaspar, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection, Maria C. Pedroso de Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir Slepushkin, and Nejat Düzgüneş

Role of lipid mixing in the physico-chemical properties of cationic liposome/DNA complexes and in their interaction with cells, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Insights into the interaction of lipoplex-mediated gene delivery: Fusion with or destabilization of the plasma membrane?, Pedro Pires, Sérgio Simões, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration. In: Copper and Zinc in Inflammatory and Degenerative Diseases, Kim D. Rainsford and Benjamin David Zeitlin