A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

Follow

Submissions from 2002

Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles, Sérgio Simões, C. Fonseca, Henrique Faneca, Nejat Düzgüneş, and Maria C. Pedroso de Lima

PDF

Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes, Conchita Tros De Ilarduya, M. A. Arangoa, M. J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 2001

Asialofetuin lipoplexes for enhanced transfection of hepatic cells, Miguel A. Arangoa, Nejat Düzgüneş, and M. Conchita Tros de Ilarduya

Link

Characterization of a monoclonal antibody reacting with antigen-4 domain of gp900 in Cryptosporidium parvum invasive stages, Alain Bonnin, David M. Ojcius, Philippe Souque, Debra A. Barnes, Patricia S. Doyle, Jiri Gut, Richard G. Nelson, Carolyn Petersen, and Jean-Francois Dubremetz

Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci, Robson Coutinho-Silva, Jean-Luc Perfettini, Pedro M. Persechini, Alice Dautry-Varsat, and David M. Ojcius

Link

Lipid assemblies for drug delivery, Nejat Düzgüneş

Link

Delivery of novel macromolecular drugs against HIV-1, Nejat Düzgüneş, Sérgio Simões, Krystyna Konopka, John J. Rossi, and Maria C. Pedroso De Lima

HIV-1 LTR- and SV40-driven gene expression is inhibited by the CMV promoter, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Secretory leukocyte protease inhibitor and HIV-1 infection of THP-1 cells, Krystyna Konopka, Nancy R. Shine, Susan C. Wang, Christian P. Whitman, and Nejat Düzgüneş

Link

Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

Link

Radical changes to chlamydial taxonomy are not necessary just yet, J. Schachter, R. S. Stephens, P. Timms, C. Kuo, Patrik M. Bavoil, S. Birkelund, J. Boman, H. Caldwell, L. A. Campbell, M. Chernesky, G. Christiansen, I. N. Clarke, C. Gaydos, J. T. Grayston, T. Hackstadt, R. Hsia, B. Kaltenboeck, M. Leinonnen, David M. Ojcius, G. McClarty, J. Orfila, R. Peeling, M. Puolakkainen, T. C. Quinn, R. G. Rank, J. Raulston, G. L. Ridgeway, P. Saikku, W. E. Stamm, D. T. Taylor-Robinson, S. P. Wang, and P. B. Wyrick

PDF

On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes, Sérgio Simões, Vladimir Slepushkin, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Submissions from 2000

Link

Closing in on Chlamydia and its intracellular bag of tricks, Patrik M. Bavoil, Ru-ching Hsia, and David M. Ojcius

Link

Fluorescent labelling of intracellular bacteria in living host cells, Haralabia Boleti, David M. Ojcius, and Alice Dautry-Varsat

Intracellular delivery of anti-HIV agents via pH-sensitive liposomes and transferrin-lipoplexes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, Nan S. Lee, John J. Rossi, Maria C. Pedroso de Lima, and Krystyna Konopka

Superior inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides encapsulated in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Enhanced inhibition of HIV-1 replication in macrophages by ribozymes, PMEA and antisense oligonucleotides delivered in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, John J. Rossi, E. De Clercq, V. P. Antao, M. L. Collins, and Maria C. Pedroso de Lima

PDF

La notion de danger, Jean M. Kanellopoulos and David M. Ojcius

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells is not affected by treatment with heparinase, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

Link

Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan Sook Lee, John Rossi, and Nejat Düzgüneş

The CMV promoter inhibits HIV-1 LTR- and SV40-driven gene expression, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Therapy for oral squamous cell carcinoma using cationic lipid-DNA complexes for gene delivery, N. C. Moser, V. V. Suzara, Krystyna Konopka, and Nejat Düzgüneş

PDF

Effect of Chlamydia trachomatis infection and subsequent TNFa secretion on apoptosis in the murine genital tract, Jean-Luc Perfettini, Toni Darville, Gabriel Gachelin, Philippe Souque, Michel Huerre, Alice Dautry-Varsat, and David M. Ojcius

PDF

Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

PDF

Efficient gene transfer by transferrin lipoplexes in the presence of serum, Conchita Tros De Ilarduya and Nejat Düzgüneş

Controlled gene delivery to cultured rat hepatocytes and adipocytes by liposomes containing transferrin, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Transfection of primary rat hepatocytes and adipocytes by transferrin lipoplexes, M. Conchita Tros de Ilarduya, Maria J. Moreno-Aliaga, and Nejat Düzgüneş

Submissions from 1999

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Chlamydia trachomatis, ennemi intérieur : de la biologie moléculaire aux modèles animaux, Patrik M. Bavoil, David M. Ojcius, Alice Dautry-Varsat, A. Souriau, F. Bernard, A. Rodolakis, and R.-C. Hsia

Link

Chlamydia infection or epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth, Haralabia Boleti, Alexandre Benmerah, David M. Ojcius, Nadine Cerf-Bensussan, and Alice Dautry-Varsat

P2Z-P2X7 receptor-mediated apoptosis of dendritic cells, Robson Coutinho-Silva, Pedro M. Persechini, R. C. Bisaggio, Jean-Luc Perfettini, A. C. T. Sa Neto, Jean M. Kanellopoulos, I. Motta, Alice Dautry-Varsat, and David M. Ojcius

Science by consensus: Why the NIH grant review system must be changed, Nejat Düzgüneş

Link

Mechanisms and kinetics of liposome-cell interactions, Nejat Düzgüneş and Shlomo Nir

Link

Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir A. Slepushkin, Krystyna Konopka, Diana Flasher, and Maria C. Pedroso De Lima

Enhanced antiviral effect of ribozymes, PMEA and antisense oligonucleotides in HIV-1-infected macrophages by delivery in pH-sensitive liposomes, Nejat Düzgüneş, Elizabeth Pretzer, Sérgio Simões, Vladimir Slepushkin, and Maria C. Pedroso de Lima

Human serum albumin enhances gene delivery by lipoplexes and confers resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Human serum albumin-lipoplexes: Enhanced gene delivery and resistance to serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Lipoplexes associated with human serum albumin or transferrin: Enhanced gene delivery to cell lines and macrophages, and resistance to inhibition by serum, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, C. Tros, Diana Flasher, and Maria C. Pedroso de Lima

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells, E. Farge, David M. Ojcius, A. Subtil, and Alice Dautry-Varsat

Highly efficient binding of cationic liposomes to Porphyromonas gingivalis, K. Farzaneh, A. Alijanian, T. Bramanti, and Nejat Düzgüneş

Antiviral activity of UIC-94-003, a novel inhibitor of the human immunodeficiency virus type-1 protease, Arun K. Ghosh, Elizabeth Pretzer, Hanna Cho, Khaja A. Hussain, W. Cho, D. E. Walters, and Nejat Düzgüneş

Binding of secretory leukocyte protease inhibitor (SLPI) to human cells does not correlate with expression of surface proteins CD4, CD26 and CCR5, Krystyna Konopka, Nejat Düzgüneş, and Nancy R. Shine

Link

Anti-HIV activity of amphotericin B-cholesteryl sulfate colloidal dispersion in vitro, Krystyna Konopka, Luke S.S. Guo, and Nejat Düzgüneş

Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication, Krystyna Konopka, Nan S. Lee, John J. Rossi, and Nejat Düzgüneş

Transferrin lipoplexes for gene therapy of HIV: Rev-binding aptamer and CMV promoter as decoys, Krystyna Konopka, Nan S. Lee, L. Scherer, John J. Rossi, and Nejat Düzgüneş

Link

Secretory leukocyte protease inhibitor (SLPI): oxidation of SLPI does not explain its variable anti-HIV activity, Krystyna Konopka, N. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

Link

Caspase-dependent apoptosis during infection with Cryptosporidium parvum, David M. Ojcius, Jean-Luc Perfettini, Alain Bonnin, and Fabrice Laurent

Link

Gene delivery mediated by cationic liposomes: From biophysical aspects to enhancement of transfection, Maria C. Pedroso De Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir A. Slepushkin, and Nejat Düzgüneş

PDF

Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells, Pedro Pires, Sérgio Simões, Shlomo Nir, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso De Lima

Mechanisms of cellular internalization of lipoplexes: A fluorescence and electron microscopy study, Pedro Pires, Sérgio Simões, B. Plowman, Nejat Düzgüneş, and Maria C. Pedroso de Lima

On the enhancing effect of transfection by proteins associated to lipoplexes, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy, Sérgio Simões, Pedro Pires, Nejat Düzgüneş, and Maria C. Pedroso De Lima

Link

Successful transfection of lymphocytes by ternary lipoplexes, Sérgio Simões, Vladimir Slepushkin, R. Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

PDF

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

PDF

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Paul Dazin, Rogério Gaspar, Maria C. Pedroso De Lima, and Nejat Düzgüneş

Serum-resistant transferrin lipoplexes, C. Tros and Nejat Düzgüneş

Efficient gene delivery to hepatocytes by transferrin-lipoplexes in the presence of serum, M. Conchita Tros de Ilarduya and Nejat Düzgüneş

Link

Zinc monoglycerolate (ZMG) and zinc salt cellular uptake profile in vitro determined by plasma mass spectrometry, Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1998

Anti-peptide antibodies inhibit HIV-1 induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

Anti-peptide antibodies inhibit HIV-1-induced syncytium formation, H. Abarghouei, L. Agrawal, D. N. Rao, Krystyna Konopka, and Nejat Düzgüneş

History lesson, Nejat Düzgüneş

Liposome-mediated delivery of antiviral drugs, antisense oligonucleotides, and therapeutic genes into HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Vladimir Slepushkin, Krystyna Konopka, Diana Flasher, Sérgio Simões, V. P. Antao, M. L. Collins, E. De Clercq, M. S. Newman, L. S. Gao, P. Dazin, G. S. Harrison, Nan S. Lee, John J. Rossi, and Maria C. Pedroso de Lima

Gene delivery by net negatively charged complexes of cationic liposomes, DNA and transferrin or pH-sensitive peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Transfection of epithelial and lymphocytic cell lines and monocyte/macrophages by net negatively charged transferrin/cationic lipid/DNA complexes, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

pH Sensitive Liposomes: A Novel Approach in Antibiotic Delivery, Pattisapu R. J. Gangadharam, Diana Flasher, M. V. Reddy, and Nejat Düzgüneş

Link

Functional gene transfer from intracellular bacteria to mammalian host cells, Catherine Grillot-Courvalin, Sylvie Goussard, Francois Huetz, David M. Ojcius, and Patrice Courvalin

Link

Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John Rossi, and Nan Sook Lee

Incorporation of amphotericin B into stealth liposomes or colloidal dispersions diminishes its in vitro anti-HIV activity, Krystyna Konopka, Luke S. S. Guo, and Vladimir Slepushkin

PDF

Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Piotr Swiderski, Vladimir A. Slepushkin, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Activities of Free and Liposome-Encapsulated Sparfloxacin against Intracellular Drug-Susceptible and Multiple Drug Resistant (MDR) Tubercle Bacilli, Julieta Luna-Herrera, M. V. Reddy, Diana Flasher, Nejat Düzgüneş, and Pattisapu R. J. Gangadharam

A comparative study of fluorescent probes for monitoring virus fusion kinetics, Isabel Nunes-Correia, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells, David M. Ojcius, Yolanda Bravo de Alba, Jean M. Kanellopoulos, Ray A. Hawkins, Kathy A. Kelly, Roger G. Rank, and Alice Dautry-Varsat

PDF

Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia: NMR studies of living cells, David M. Ojcius, H. Degani, Joel Mispelter, and Alice Dautry-Varsat

Pore-forming proteins, David M. Ojcius, Chau-Ching Liu, and John Ding-E. Young

Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci, David M. Ojcius, Philippe Souque, Jean-Luc Perfettini, and Alice Dautry-Varsat

Development of novel non-viral gene transfer vectors, Maria C. Pedroso de Lima, Rogério Gaspar, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection, Maria C. Pedroso de Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir Slepushkin, and Nejat Düzgüneş

Role of lipid mixing in the physico-chemical properties of cationic liposome/DNA complexes and in their interaction with cells, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Insights into the interaction of lipoplex-mediated gene delivery: Fusion with or destabilization of the plasma membrane?, Pedro Pires, Sérgio Simões, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration. In: Copper and Zinc in Inflammatory and Degenerative Diseases, Kim D. Rainsford and Benjamin David Zeitlin

Enhancement of clarithromycin's water solubility via cyclodextrin complexation and efficacy study against Mycobacterium avium complex, Isam Ismail Salem and Nejat Düzgüneş

PDF

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides, Sérgio Simões, Vladimir Slepushkin, R. Caspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Delivery of antisense oligonucleotides and ribozymes mediated by pH-sensitive liposomes enhances their anti-HIV effect, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cellular uptake profile for zinc monoglycerolate (ZMG) in immune and gastric cell lines determined by fluorescence photomicrography and inductively coupled plasma mass spectrometry (ICP-MS), Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1997

Inhibition of HIV-1 replication by protease inhibitors, antisense oligonucleotides, and therapeutic genes delivered in liposomes, Nejat Düzgüneş, Krystyna Konopka, Elizabeth Pretzer, Vladimir A. Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, and John J. Rossi

Liposome-mediated delivery of antiviral drugs to HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Krystyna Konopka, Vladimir Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, E. De Clercq, and John J. Rossi

Gene delivery by anionic complexes of transferrin/cationic lipid/DNA., Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusogenic peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Link

Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity, Laurent Gapin, Jean-Pierre Cabaniols, Ricardo Cibotti, David M. Ojcius, Philippe Kourilsky, and Jean M. Kanellopoulos

Link

Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells, Cesar Gutiérrez-Martín, David M. Ojcius, Ru-Ching Hsia, Raymond Hellio, Patrik M. Bavoil, and Alice Dautry-Varsat

Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John J. Rossi, and Nan S. Lee

PDF

Cationic liposome-mediated expression of HIV-regulated luciferase and diphtheria toxin a genes in HeLa cells infected with or expressing HIV, Krystyna Konopka, Gail S. Harrison, Philip L. Felgner, and Nejat Düzgüneş

Inhibition of HIV infection by secretory leukocyte protease inhibitor, Krystyna Konopka, Nancy R. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

Lymphocyte-mediated cytotoxicity, David M. Ojcius, Z. A. Cohn, and John Ding-E Young

PDF

Distribution of endosomal, lysosomal and MHC markers in a monocytic cell line infected with Chlamydia psittaci, David M. Ojcius, Raymond Hellio, and Alice Dautry-Varsat

Interaction of cationic liposomes with cells: Effect of several factors on liposome-cell fusion, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Link

Inhibition of human immunodeficiency virus type-1 replication in macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana L. Flasher, and Nejat Düzgüneş