ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Infection and Immunity
ISSN
0019-9567
Volume
65
Issue
6
First Page
2437
Last Page
2442
Publication Date
6-1-1997
Abstract
The intracellular fate of Chlamydia psittaci during infection of a monocytic cell line, THP1, was characterized. Cytochalasin D inhibited phagocytosis of latex beads but had no effect on infection by C. psittaci, and vacuoles expressed the transferrin receptor, suggesting accessibility to the endocytic pathway. Early Chlamydia-containing vacuoles expressed major histocompatibility complex (MHC) class I molecules, and most vacuoles fused with host cell lysosomes, since they expressed LAMP-1 and had acidic pHs. In cells prestimulated with gamma interferon, vacuoles also expressed MHC class II molecules, suggesting that the monocytes might effectively process Chlamydia-derived antigens for presentation by MHC class I and class II molecules.
Recommended Citation
Ojcius, D. M.,
Hellio, R.,
&
Dautry-Varsat, A.
(1997).
Distribution of endosomal, lysosomal and MHC markers in a monocytic cell line infected with Chlamydia psittaci.
Infection and Immunity, 65(6), 2437–2442.
https://scholarlycommons.pacific.edu/dugoni-facarticles/194
Included in
Biochemistry Commons, Immunity Commons, Immunology of Infectious Disease Commons, Medical Immunology Commons
