Presentation of antigens derived from microorganisms residing in host-cell vacuoles

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Trends in Microbiology

ISSN

0966-842X

Volume

4

Issue

2

DOI

10.1016/0966-842X(96)81511-3

First Page

53

Last Page

59

Publication Date

2-1-1996

Abstract

Antigens presented by major histocompatibility complex molecules have been classified into those presented by ‘endogenous’ and ‘exogenous’ pathways. Some microorganisms reside within host-cell vacuoles that appear to avoid both pathways. Novel presentation mechanisms are being unraveled for these microorganisms, and their antigens, rather than being just peptides, can also consist of lipids or DNA fragments.

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