ORCiD
Nejat Düzgüneş: 0000-0001-6159-1391
Department
Biomedical Sciences
Document Type
Article
Publication Title
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
Volume
40
Issue
11
DOI
10.1128/aac.40.11.2618
First Page
2618
Last Page
2621
Publication Date
1-1-1996
Abstract
Mycobacterium avium-M. intracellulare complex (MAC) is the most frequent cause of opportunistic bacterial infection in patients with AIDS. Previous studies have indicated that liposome-encapsulated aminoglycosides are highly effective in treating MAC infections in mice. We investigated whether the fluoroquinolone sparfloxacin is effective in treating MAC infection in the murine macrophage-like cell line J774. Sparfloxacin was encapsulated in the membrane phase of multilamellar liposomes composed of phosphatidylglycerol-phosphatidylcholine-cholesterol (1:1:1 molar ratio). MAC-infected macrophages were treated for either 24 h or 4 days with free or liposome-encapsulated sparfloxacin. Treatment with free or liposome- encapsulated sparfloxacin (6 μg/ml) for 24 h resulted in the reduction of the growth index to 25 and 30% of that of untreated controls, respectively. When cultures were treated for 4 days, free sparfloxacin reduced the growth index to 6% of that of the untreated control, while liposome-encapsulated sparfloxacin reduced it to 8% of that of the control.
Recommended Citation
Düzgüneş, N.,
Flasher, D. L.,
Reddy, M. V.,
Luna-Herrera, J.,
&
Gangadharam, P. R.
(1996).
Treatment of intracellular Mycobacterium avium complex infection by free and liposome-encapsulated sparfloxacin.
Antimicrobial Agents and Chemotherapy, 40(11), 2618–2621.
DOI: 10.1128/aac.40.11.2618
https://scholarlycommons.pacific.edu/dugoni-facarticles/534
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This work is licensed under a Creative Commons Attribution 4.0 International License.
