A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 2011

HIV-specific transgene expression via progressively truncated Tat-Responsive LTR promoters, J. King, Senait Gebremedhin, Krystyna Konopka, M. Milnes, and Nejat Düzgüneş

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Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages, Camila Marques-da-Silva, Geoffrey Burnstock, David M. Ojcius, and Robson Coutinho-Silva

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Infection with Leishmania amazonensis upregulates purinergic receptor expressionand induces host-cell susceptibility to UTP-mediated apoptosis, Camila Marques-da-Silva, M. M. Chaves, S. P. Chaves, V. R. Figliuolo, J. R. Meyer-Fernandes, S. Corte-Real, C. Lameu, H. Ulrich, David M. Ojcius, B. Rossi-Bergmann, and Robson Coutinho-Silva

Role of Endogenous Glucocorticoids In the Regulation of Eosinopoiesis In A Murine Model For Allergic Asthma, Daniela Masid-De-Brito, Pedro Xavier-Elsas, Ricardo Alves Luz, Cássio Luiz Coutinho Almeida-da-Silva, Túlio Queto, and Maria Ignez Capella Gaspar-Elsas

Role Of Endogenous Glucocorticoids In The Regulation Of Eosinopoiesis In A Murine Model For Allergic Asthma, Daniela Masid-De-Brito, Pedro Xavier-Elsas, Ricardo Alves Luz, Túlio Queto, Cássio Luiz Coutinho Almeida-da-Silva, Rodrigo Soares Lopes, Bruno Marques Vieira, and Maria Ignez Capella Gaspar-Elsas

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Periodontal ligament and gingival fibroblasts participate in the production of TGF-β, interleukin (IL)-8 and IL-10, Ana Carolina Morandini, Carla Renata Sipert, Erivan Schnaider Ramos-Junior, Daniel Thomas Brozoski, and Carlos Ferreira Santos

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D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma, S. D. Nandedkar, D. Weihrauch, H. Xu, Y. Shi, T. Feroah, W. Hutchins, D. A. Rickaby, Nejat Düzgüneş, C. A. Hillery, K. S. Konduri, and K. A. Pritchard

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Comparative analysis of two colorimetric assays in dental pulp cell density. International Endodontic Journal, Fernanda Nedel, Fabiana Naomi Soki, Marcus Cristian Muniz Conde, Benjamin David Zeitlin, Sandra Beatriz Chaves Tarquinio, Jacques E. Nör, Fabiana Kömmling Seixas, and Flavio F. Demarco

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Serum-derived nanoparticles: de novo generation and growth in vitro, and internalization by mammalian cells in culture, Hsin-Hsin Peng, Jan Martel, Yu-Hsiu Lee, David M. Ojcius, and John Ding-E. Young

Toll-like Receptor 4(TLR4) is expressed in Pulp Fibroblasts After Stimulation with Candida albicans, C. R. Pinheiro, Carla Renata Sipert, Thaís Helena Gasparoto, C. E. Oliveira, M. S. Silva, Ana Carolina Morandini, Gustavo P. Garlet, Carlos Ferreira Santos, J. S. Silva, and Ana Paula Campanelli

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Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering, Vivien Thiemy Sakai, Mabel Mariela Cordeira, Zhihong Dong, Zhaocheng Zhang, Benjamin David Zeitlin, and Jacques E. Nör

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Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection, Claire Séror, Marie-Therese Melki, Frederic Subra, Syed Qasim Raza, Marlene Bras, Hela Saïdi, Roberta Nardacci, Laurent Voisin, Audrey Paoletti, Frederic Law, Isabelle Martins, Alessandra Amendola, Ali A. Abdul-Sater, Fabiola Ciccosanti, Olivier Delelis, Florence Niedergang, Sylvain Thierry, Najwane Said-Sadier, Christophe Lamaze, Didier Métivier, Jerome Estaquier, Gian Maria Fimia, Laura Falasca, Rita Casetti, Nazanine Modjtahedi, Jean M. Kanellopoulos, Jean-Francois Mouscadet, David M. Ojcius, Mauro Piacentini, Marie-Lise Gougeon, Guido Kroemer, and Jean-Luc Perfetini

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Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection, Kenichi Shimada, Timothy R. Crother, Justin Karlin, Shuang Chen, Norika Chiba, V. Krishnan Ramanujan, Laurent Vergnes, David M. Ojcius, and Moshe Arditi

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Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages, Naraporn Somboonna, Raymond Wan, David M. Ojcius, Matthew A. Pettengill, Sandeep J. Joseph, Alexander Chang, Ray Hsu, Timothy D. Read, and Deborah Dean

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Epithelial cell type affects interleukin-6 response to Porphyromonas gingivalis, Michael Yee, T. Alpagot, Nejat Düzgüneş, and Krystyna Konopka

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Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule, Benjamin David Zeitlin and Jacques E. Nör

Submissions from 2010

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Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1, Ali A. Abdul-Sater, Najwene Saïd-Sadier, Verissa M. Lam, Bhavni Singh, Matthew A. Pettengill, Fraser Soares, Ivan Tattoli, Simone Lipinski, Stephen E. Girardin, Philip Rosenstiel, and David M. Ojcius

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Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome, Ali A. Abdul-Sater, Najwene Saïd-Sadier, Eduardo V. Padilla, and David M. Ojcius

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Puramatrix: An injectable scaffold for dental pulp tissue engineering., Bruno Das Neves Cavalcanti, Benjamin David Zeitlin, and Jacques E. Nör

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Effects of Morphogen and Scaffold Porogen on the Differentiation of Dental Pulp Stem Cells, Flavio F. Demarco, Luciano Casagrande, Zhaocheng Zhang, Zhihong Dong, Sandra Beatriz Chaves Tarquinio, Benjamin David Zeitlin, Songtao Shi, Anthony J. Smith, and Jacques E. Nör

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Lectins and T-20, but not neutralizing antibodies, inhibit HIV-1 Env-mediated syncytium formation between Clone69T1RevEnv and SupT1 cells monitored by fluorescence microscopy, Nejat Düzgüneş, Michael Yee, Jan Balzarini, and Krystyna Konopka

Cell-penetrating peptides enhance gene delivery by lipid-DNA complexes, J. Fountain, Senait Gebremedhin, Krystyna Konopka, and Nejat Düzgüneş

Overcoming the lipofection resistance of oral cancer cells: polyplexes and adenoviruses, Senait Gebremedhin, Krystyna Konopka, I. Ulasov, M. Lesniak, and Nejat Düzgüneş

Efficient gene delivery to oral cancer cells by polyethylenimine-DNA complexes, Senait Gebremedhin, F. Martinez, J. Fountain, Krystyna Konopka, and Nejat Düzgüneş

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From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway, Ricardo Jose Giordano, Marina Cardo-Vila, Ahmad Salameh, Cristiane D. Anobom, Benjamin David Zeitlin, David H. Hawke, Ana Paula Valente, Fabio C. L. Almeida, Jacques E. Nör, Richard L. Sidman, and Renata Pasqualini

Cytokine responses of oral epithelial cells exposed to Porphyromonas gingivalis, Shawn Kim, Michael Yee, T. Alpagot, Nejat Düzgüneş, and Krystyna Konopka

Gene expression mediated by progressively truncated HIV-LTR promoters and HIV-Tat: How to kill HIV-infected cells, J. King, Senait Gebremedhin, Krystyna Konopka, Nejat Düzgüneş, and M. Milnes

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Susceptibility of Candida biofilms to histatin 5 and fluconazole, Krystyna Konopka, Barbara Dorocka-Bobkowska, Senait Gebremedhin, and Nejat Düzgüneş

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Susceptibility of Candida biofilms to histatin-5 and fluconazole, Krystyna Konopka, Barbara Dorocka-Bobkowska, Senait Gebremedhin, J. Wilson, and Nejat Düzgüneş

Cationic liposome enhancement of adenoviral vectors for gene delivery to OSCC, G. Lim, Senait Gebremedhin, J. Ouellette, I. Ulasov, M. Lesniak, Krystyna Konopka, and Nejat Düzgüneş

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Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin, Shijun Li, David M. Ojcius, Sumei Liao, Liwei Li, Feng Xue, Haiyan Dong, and Jie Yan

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Differential production of macrophage inflammatory protein-1alpha, stromal-derived factor-1, and IL-6 by human cultured periodontal ligament and gingival fibroblasts challenged with lipopolysaccharide from P. gingivalis, Ana Carolina Morandini, Carla Renata Sipert, Thaís Helena Gasparoto, Sebastião Luiz A. Greghi, Euloir Passanezi, Maria Lucia R. Rezende, Adriana Campos Passanezi Sant'ana, Ana Paula Campanelli, Gustavo P. Garlet, and Carlos Ferreira Santos

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Microbes and Infection: past, present and future, David M. Ojcius and Stefan H. E. Kaufmann

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Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase, Najwane Saïd-Sadier, Eduardo V. Padilla, Gordon Langsley, and David M. Ojcius

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Gene delivery by lipoplexes and polyplexes, Conchita Tros de Ilarduya, Yan Sun, and Nejat Düzgüneş

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Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1, Junyu Xu, Nan (Tori) Xiao, and Jun Xia

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Effect of crocetin on blood pressure restoration and synthesis of inflammatory mediators in heart after hemorrhagic shock in anesthetized rats, Junling Yan, Zhi Yu Qian, Liang Sheng, Bohua Zhao, Lina Yang, Hui Ji, Xiaoyuan Han, and Rong Zhang

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Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells, L. Yao, C. Jermanus, B. Barbetta, C. Choi, Philippe Verbeke, David M. Ojcius, and Özlem Yilmaz

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Porphyromonas gingivalis stimulates IL-18 secretion in monocytic THP-1 cells, Michael Yee, A. Kim, Nejat Düzgüneş, T. Alpagot, and Krystyna Konopka

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HIV-1 Env-mediated membrane fusion monitored by fluorescence microscopy of syncytium formation between Clone69T1RevEnv and SupT1 cells, Michael Yee, Krystyna Konopka, Jan Balzarini, and Nejat Düzgüneş

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ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis, Özlem Yilmaz, Ali A. Abdul-Sater, L. Yao, T. Koutouzis, Matthew A. Pettengill, and David M. Ojcius

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Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation, Benjamin David Zeitlin, Aaron C. Spalding, Marcia S. Campos, Naoki Ashimori, Zhihong Dong, Shaomeng Wang, Theodore S. Lawrence, and Jacques E. Nör

Submissions from 2009

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Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis, Ali A. Abdul-Sater, Evonne Koo, Georg Hacker, and David M. Ojcius

Inflammasomes bridge signalling between pathogen identification and the immune response, Ali A. Abdul-Sater, Najwene Saïd-Sadier, David M. Ojcius, O. Yilmaz, and Kathy A. Kelly

Anti-tumor and anti-angiogenic effect of TW37 and Cisplatin combination therapy, Naoki Ashimori, Benjamin David Zeitlin, Kristy Warner, and Jacques E. Nör

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TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis, Naoki Ashimori, Benjamin David Zeitlin, Zhaocheng Zhang, Kristy Warner, Ilan M. Turkienicz, Aaron C. Spalding, Theodoros N. Teknos, Shaomeng Wang, and Jacques E. Nör

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The oral microbiota: living with a permanent guest, Maria Avila, David M. Ojcius, and Ozlem Yilmaz

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The P2X7 receptor and intracellular pathogens: a continuing struggle, Robson Coutinho-Silva, Gladys Corrêa, Ali A. Abdul-Sater, and David M. Ojcius

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A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis, Robert C. Doebele, Frank Thilo Schulze-Hoepfner, Jia Hong, Alexandre Chlenski, Benjamin David Zeitlin, Kushboo Goel, Suzana Gomes, Yuru Liu, Mark K. Abe, Jacques E. Nör, and Mark W. Lingen

AmBisome and amphotericin B inhibit the initial adherence of Candida albicans to human epithelial cell lines, but do not cause yeast detachment, Barbara Dorocka-Bobkowska, Nejat Düzgüneş, and Krystyna Konopka

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Comparison of Effect on Isoproterenol-induced Myocardial Injury Between Crocetin and Crocin / 比较西红花酸和西红花苷对异丙肾上腺素损伤心肌的作用, Xiaoyuan Han, Zhiyu Qian, Zhang Rong, Zhen Chen, Junling Yan, and Lina Yang

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Leptospira interrogans induces apoptosis in macrophages via caspase-8- and -3-dependent pathways, Dandan Jin, David M. Ojcius, Dexter Sun, Haiyan Dong, Yihui Luo, Yafei Mao, and Jie Yan

Inflammatory cytokine secretion by THP-1 cells exposed to Porphyromonas gingivalis, A. Kim, Michael Yee, Nejat Düzgüneş, T. Alpagot, and Krystyna Konopka

Inflammatory cytokine secretion by THP-1 cells exposed to Porphyromonas gingivalis, A. Kim, Michael Yee, Nejat Düzgüneş, T. Alpagot, and Krystyna Konopka

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Correlation between the levels of survivin and survivin promoter-driven gene expression in cancer and non-cancer cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, and Nejat Düzgüneş

Gene delivery to oral cancer cells by nonviral vectors: why some cells are resistant to transfection., Cassidy Lavorini-Doyle, Senait Gebremedhin, Krystyna Konopka, and Nejat Düzgüneş

Intracellular fate of non-viral vectors in oral cancer cells, Cassidy Lavorini-Doyle, Senait Gebremedhin, Krystyna Konopka, and Nejat Düzgüneş

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Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai, Sumei Liao, Ai-Hua Sun, David M. Ojcius, Senlin Wu, Jinfang Zhao, and Jie Yan

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Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp. and characterization of their immunogenicity, Dongjiao Luo, Feng Xue, David M. Ojcius, Jinfang Zhao, Ya-Fei Mao, Liwei Li, Xu'ai Lin, and Jie Yan

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An iterative strategy combining biophysical criteria and duration hidden Markov) models for structural predictions of Chlamydia trachomatis s66 promoters, Ronna R. Mallios, David M. Ojcius, and David H. Ardell

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Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, and M. C. Pedroso De Lima

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Chikungunya fever: re-emergence of an old disease, Lisa F. P. Ng and David M. Ojcius

Enhancing gene delivery to cancer cells by transferrin and EGF, J. Ouellette, Senait Gebremedhin, Krystyna Konopka, and Nejat Düzgüneş

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The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope, Jean-Luc Perfettini, Roberta Nardacci, C. Séror, M. Bourouba, F. Subra, L. Gros, Gwenola Manic, A. Amendola, P. Masdehors, F. Rosselli, David M. Ojcius, C. Auclair, H. de Thé, M. L. Gougeon, M. Piacentini, and G. Kroemer

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The danger signal adenosine induces persistence of chlamydial infection through stimulation of A2b receptors, Matthew A. Pettengill, Verissa W. Lam, and David M. Ojcius

Differential production of CXCL12 by Cultured human dental pulp and gingival fibroblasts challenged by Porphyromonas gingivalis LPS and Escherichia coli LPS, Carla Renata Sipert, Ana Carolina Morandini, S. H. P. Oliveira, Ana Paula Campanelli, and Carlos Ferreira Santos

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNg in human epithelial cells, L. Welter-Stahl, C. M. da Silva, Julieta Schachter, Pedro M. Persechini, H. S. Souza, David M. Ojcius, and Robson Coutinho-Silva

Effects of antifungals and histatin 5 on Candida albicans biofilms, J. Wilson, Senait Gebremedhin, Nejat Düzgüneş, and Krystyna Konopka

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PICK1 deficiency causes male infertility in mice by disrupting acrosome formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, and Jun Xia

HIV-1 Env-mediated cell-cell fusion is inhibited by lectins and peptides, but not by antibodies that inhibit infection, Michael Yee, Krystyna Konopka, Jan Balzarini, and Nejat Düzgüneş

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Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death, Benjamin David Zeitlin, Lee M. Ellis, and Jacques E. Nör

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Comparison of the effects of crocetin and crocin on myocardial injury in rats, Rong Zhang, Zhi Yu Qian, Xiaoyuan Han, Zhen Chen, Jun Ling Yan, and A. Hamid

Submissions from 2008

Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity, Ali A. Abdul-Sater, David M. Ojcius, and M. P. Meyer

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The association between gingival crevicular fluid TGF-β1 levels and periodontal status in HIV-1+ patients, Tamer Alpagot, Krystyna Konopka, Mouchumi Bhattacharyya, S. Gebremedhin, and Nejat Düzgüneş

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The book reopened on infectious diseases, Maria Avila, Najwane Said, and David M. Ojcius

Oral epithelial cells exposed to Porphyromonas gingivalis: Analysis of genes relevant to periodontal disease, B. Behdad, V. Suzara, and Nejat Düzgüneş

Epac/Rap1 inhibit endothelial cell chemotaxis and angiogenesis via induction of Thrombospondin-1, Robert C. Doebele, Frank Thilo Schulze-Hoepfner, Alexandre Chlenski, Kushboo Goel, Jia Hong, Yuru Liu, Mark K. Abe, Mark W. Lingen, Benjamin David Zeitlin, Jacques E. Nör, and Marsha Rich Rosner

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Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein, Haiyan Dong, Ye Hu, Feng Xue, Dexter Sun, David M. Ojcius, Yafei Mao, and Jie Yan

Sitimagene ceradenovec, a gene therapeutic for the treatment of glioma, Nejat Düzgüneş

Longitudinal evaluation of GCF interleukin-18 and Periodontitis in HIV+ patients, M. Hashimoto, T. Alpagot, Mouchumi Bhattacharyya, Krystyna Konopka, Senait Gebremedhin, and Nejat Düzgüneş

Survivin promoter-driven gene expression in cancer and non-cancer cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, and Nejat Düzgüneş

Transferrin-lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in a murine model, Sílvia S. Neves, Henrique Faneca, Samuel Bertin, Krystyna Konopka, Nejat Düzgüneş, Valérie Pierrefite-Carle, Sérgio P. Simões, and Maria C. Pedroso de Lima

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Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease, Stefan A. Paschen, Jan G. Christian, Juliane Vier, Franziska Schmidt, Axel Walch, David M. Ojcius, and Georg Hacker

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Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia, Jean-Luc Perfettini, Roberta Nardacci, Mehdi Bourouba, Frederic Subra, Laurent Gros, Claire Séror, Gwenola Manic, Filippo Rosselli, Alessandra Amendola, Peggy Masdehors, Luciana Chessa, Giuseppe Novelli, David M. Ojcius, Jan Konrad Siwicki, Magdalena Chechlinska, Christian Auclair, Jose R. Regueiro, Hughes de Thé, Marie-Lise Gougeon, Mauro Piacentini, and Guido Kroemer

L’Apoptose, J. L. Perfettini, David M. Ojcius, and G. Kroemer

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Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines, Ping Ruan, Xiao-Ping Xia, Dexter Sun, David M. Ojcius, Ya-Fei Yao, Wen-Yue Yue, and Jie Yan

Use of platelet-rich plasma (PRP ) in combination with sub- epithelial connective graft for root coverage in smoker patient : case report, S. Salmeron, Ana Carolina Morandini, E. A. Figueira, Adriana Campos Passanezi Sant'ana, M. L. R. Rezende, and S. L. A. Greghi

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Enzastaurin, an inhibitor of PKC beta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells., Aaron C. Spalding, Benjamin David Zeitlin, Kari Wilder-Romans, Mary Ellen Davis, Jacques E. Nör, Theodore S. Lawrence, and Edgar Ben-Josef

The association between GCF VEGF and periodontitis in HIV+ patients, E. Unger, T. Alpagot, Mouchumi Bhattacharyya, Krystyna Konopka, Senait Gebremedhin, and Nejat Düzgüneş

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ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X(7)-mediated host-cell apoptosis, Özlem Yilmaz, L. Yao, K. Maeda, T. M. Rose, E. L. Lewis, M. Duman, R. J. Lamont, and David M. Ojcius

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Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development, Songmin Ying, Matthew A. Pettengill, E. Ray Latham, Axel Walch, David M. Ojcius, and Georg Hacker

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Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 asanticancer cell and antiangiogenic agents, Benjamin David Zeitlin, Isaac J. Zeitlin, and Jacques E. Nör

Submissions from 2007

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Longitudinal evaluation of prostaglandin E2 (PGE2) and periodontal status in HIV+ patients, Tamer Alpagot, John Remien, Mouchumi Bhattacharyya, Krystyna Konopka, William Lundergan, and Nejat Düzgüneş

The relationship between TGF-beta and periodontal status in HIV+ patients, T. Alpagot, Krystyna Konopka, Mouchumi Bhattacharyya, and Nejat Düzgüneş

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The role of P2 receptors in controlling infections by intracellular pathogens, Robson Coutinho-Silva, Christiane Monteiro da Cruz, Pedro M. Persechini, and David M. Ojcius

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ATP activates a Reactive Oxygen Species-dependent oxidative stress response and secretion of pro-inflammatory cytokines in macrophages, Christiane M. Cruz, Alessandra Rinna, Henry Jay Forman, Ana L. M. Ventura, Pedro M. Persechini, and David M. Ojcius

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Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally-infected mice, Toni Darville, Lynn Welter-Stahl, Christiane Cruz, Ali Abdul-Sater, Charles W. Andrews Jr., and David M. Ojcius

Activated Epac and Rap1 are Novel Inhibitors of Tumor Angiogenesis, Robert C. Doebele, Jia Hong, Mark W. Lingen, Benjamin David Zeitlin, Jacques E. Nör, Yuru Liu, Mark K. Abe, and Marsha Rich Rosner

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Level of endothelial cell apoptosis required for a significant decrease in microvessel density, Zhihong Dong, Benjamin David Zeitlin, Wenying Y. Song, Qinghua H. Sun, Elisabeta Karl, David M. Spencer, Harsh Vardhan Jain, Trachette L. Jackson, Gabriel Nunez, and Jacques E. Nör

A new paradigm for NIH grants, Nejat Düzgüneş