A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 2009

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Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai, Sumei Liao, Ai-Hua Sun, David M. Ojcius, Senlin Wu, Jinfang Zhao, and Jie Yan

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Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp. and characterization of their immunogenicity, Dongjiao Luo, Feng Xue, David M. Ojcius, Jinfang Zhao, Ya-Fei Mao, Liwei Li, Xu'ai Lin, and Jie Yan

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An iterative strategy combining biophysical criteria and duration hidden Markov) models for structural predictions of Chlamydia trachomatis s66 promoters, Ronna R. Mallios, David M. Ojcius, and David H. Ardell

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Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, and M. C. Pedroso De Lima

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Chikungunya fever: re-emergence of an old disease, Lisa F. P. Ng and David M. Ojcius

Enhancing gene delivery to cancer cells by transferrin and EGF, J. Ouellette, Senait Gebremedhin, Krystyna Konopka, and Nejat Düzgüneş

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The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope, Jean-Luc Perfettini, Roberta Nardacci, C. Séror, M. Bourouba, F. Subra, L. Gros, Gwenola Manic, A. Amendola, P. Masdehors, F. Rosselli, David M. Ojcius, C. Auclair, H. de Thé, M. L. Gougeon, M. Piacentini, and G. Kroemer

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The danger signal adenosine induces persistence of chlamydial infection through stimulation of A2b receptors, Matthew A. Pettengill, Verissa W. Lam, and David M. Ojcius

Differential production of CXCL12 by Cultured human dental pulp and gingival fibroblasts challenged by Porphyromonas gingivalis LPS and Escherichia coli LPS, Carla Renata Sipert, Ana Carolina Morandini, S. H. P. Oliveira, Ana Paula Campanelli, and Carlos Ferreira Santos

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNg in human epithelial cells, L. Welter-Stahl, C. M. da Silva, Julieta Schachter, Pedro M. Persechini, H. S. Souza, David M. Ojcius, and Robson Coutinho-Silva

Effects of antifungals and histatin 5 on Candida albicans biofilms, J. Wilson, Senait Gebremedhin, Nejat Düzgüneş, and Krystyna Konopka

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PICK1 deficiency causes male infertility in mice by disrupting acrosome formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, and Jun Xia

HIV-1 Env-mediated cell-cell fusion is inhibited by lectins and peptides, but not by antibodies that inhibit infection, Michael Yee, Krystyna Konopka, Jan Balzarini, and Nejat Düzgüneş

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Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death, Benjamin David Zeitlin, Lee M. Ellis, and Jacques E. Nör

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Comparison of the effects of crocetin and crocin on myocardial injury in rats, Rong Zhang, Zhi Yu Qian, Xiaoyuan Han, Zhen Chen, Jun Ling Yan, and A. Hamid

Submissions from 2008

Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity, Ali A. Abdul-Sater, David M. Ojcius, and M. P. Meyer

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The association between gingival crevicular fluid TGF-β1 levels and periodontal status in HIV-1+ patients, Tamer Alpagot, Krystyna Konopka, Mouchumi Bhattacharyya, S. Gebremedhin, and Nejat Düzgüneş

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The book reopened on infectious diseases, Maria Avila, Najwane Said, and David M. Ojcius

Oral epithelial cells exposed to Porphyromonas gingivalis: Analysis of genes relevant to periodontal disease, B. Behdad, V. Suzara, and Nejat Düzgüneş

Epac/Rap1 inhibit endothelial cell chemotaxis and angiogenesis via induction of Thrombospondin-1, Robert C. Doebele, Frank Thilo Schulze-Hoepfner, Alexandre Chlenski, Kushboo Goel, Jia Hong, Yuru Liu, Mark K. Abe, Mark W. Lingen, Benjamin David Zeitlin, Jacques E. Nör, and Marsha Rich Rosner

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Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein, Haiyan Dong, Ye Hu, Feng Xue, Dexter Sun, David M. Ojcius, Yafei Mao, and Jie Yan

Sitimagene ceradenovec, a gene therapeutic for the treatment of glioma, Nejat Düzgüneş

Longitudinal evaluation of GCF interleukin-18 and Periodontitis in HIV+ patients, M. Hashimoto, T. Alpagot, Mouchumi Bhattacharyya, Krystyna Konopka, Senait Gebremedhin, and Nejat Düzgüneş

Survivin promoter-driven gene expression in cancer and non-cancer cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, and Nejat Düzgüneş

Transferrin-lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in a murine model, Sílvia S. Neves, Henrique Faneca, Samuel Bertin, Krystyna Konopka, Nejat Düzgüneş, Valérie Pierrefite-Carle, Sérgio P. Simões, and Maria C. Pedroso de Lima

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Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease, Stefan A. Paschen, Jan G. Christian, Juliane Vier, Franziska Schmidt, Axel Walch, David M. Ojcius, and Georg Hacker

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Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia, Jean-Luc Perfettini, Roberta Nardacci, Mehdi Bourouba, Frederic Subra, Laurent Gros, Claire Séror, Gwenola Manic, Filippo Rosselli, Alessandra Amendola, Peggy Masdehors, Luciana Chessa, Giuseppe Novelli, David M. Ojcius, Jan Konrad Siwicki, Magdalena Chechlinska, Christian Auclair, Jose R. Regueiro, Hughes de Thé, Marie-Lise Gougeon, Mauro Piacentini, and Guido Kroemer

L’Apoptose, J. L. Perfettini, David M. Ojcius, and G. Kroemer

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Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines, Ping Ruan, Xiao-Ping Xia, Dexter Sun, David M. Ojcius, Ya-Fei Yao, Wen-Yue Yue, and Jie Yan

Use of platelet-rich plasma (PRP ) in combination with sub- epithelial connective graft for root coverage in smoker patient : case report, S. Salmeron, Ana Carolina Morandini, E. A. Figueira, Adriana Campos Passanezi Sant'ana, M. L. R. Rezende, and S. L. A. Greghi

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Enzastaurin, an inhibitor of PKC beta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells., Aaron C. Spalding, Benjamin David Zeitlin, Kari Wilder-Romans, Mary Ellen Davis, Jacques E. Nör, Theodore S. Lawrence, and Edgar Ben-Josef

The association between GCF VEGF and periodontitis in HIV+ patients, E. Unger, T. Alpagot, Mouchumi Bhattacharyya, Krystyna Konopka, Senait Gebremedhin, and Nejat Düzgüneş

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ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X(7)-mediated host-cell apoptosis, Özlem Yilmaz, L. Yao, K. Maeda, T. M. Rose, E. L. Lewis, M. Duman, R. J. Lamont, and David M. Ojcius

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Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development, Songmin Ying, Matthew A. Pettengill, E. Ray Latham, Axel Walch, David M. Ojcius, and Georg Hacker

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Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 asanticancer cell and antiangiogenic agents, Benjamin David Zeitlin, Isaac J. Zeitlin, and Jacques E. Nör

Submissions from 2007

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Longitudinal evaluation of prostaglandin E2 (PGE2) and periodontal status in HIV+ patients, Tamer Alpagot, John Remien, Mouchumi Bhattacharyya, Krystyna Konopka, William Lundergan, and Nejat Düzgüneş

The relationship between TGF-beta and periodontal status in HIV+ patients, T. Alpagot, Krystyna Konopka, Mouchumi Bhattacharyya, and Nejat Düzgüneş

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The role of P2 receptors in controlling infections by intracellular pathogens, Robson Coutinho-Silva, Christiane Monteiro da Cruz, Pedro M. Persechini, and David M. Ojcius

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ATP activates a Reactive Oxygen Species-dependent oxidative stress response and secretion of pro-inflammatory cytokines in macrophages, Christiane M. Cruz, Alessandra Rinna, Henry Jay Forman, Ana L. M. Ventura, Pedro M. Persechini, and David M. Ojcius

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Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally-infected mice, Toni Darville, Lynn Welter-Stahl, Christiane Cruz, Ali Abdul-Sater, Charles W. Andrews Jr., and David M. Ojcius

Activated Epac and Rap1 are Novel Inhibitors of Tumor Angiogenesis, Robert C. Doebele, Jia Hong, Mark W. Lingen, Benjamin David Zeitlin, Jacques E. Nör, Yuru Liu, Mark K. Abe, and Marsha Rich Rosner

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Level of endothelial cell apoptosis required for a significant decrease in microvessel density, Zhihong Dong, Benjamin David Zeitlin, Wenying Y. Song, Qinghua H. Sun, Elisabeta Karl, David M. Spencer, Harsh Vardhan Jain, Trachette L. Jackson, Gabriel Nunez, and Jacques E. Nör

A new paradigm for NIH grants, Nejat Düzgüneş

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Serum-resistant lipopolyplexes for gene delivery to liver tumour cells, Leire García, Maria Buñuales, Nejat Düzgüneş, and Conchita Tros de Ilarduya

HIV-1 envelope glycoprotein-mediated membrane fusion monitored by fluorescence microscopy, A. Ghandi, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

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Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth, Tomoatsu Kaneko, Zhaocheng Zhang, Maria G. Mantellini, Mark W. Lingen, Robert M. Strieter, Gabriel Nunez, and Jacques E. Nör

The effect of daily apolipoprotein A-I mimetic therapy on T15-type autoantibodies against oxidized phosphatidylcholine in a murine model of asthma, Kameswari S. Konduri, Sandhya D. Nandedkar, D. Weilrauch, D. A. Rickaby, Nejat Düzgüneş, and K. A. Pritchard

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Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain, L. Li, David M. Ojcius, and J. Yan

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Expression of recombinant proteins in Pichia pastoris, Pingzuo Li, Anukanth Anumanthan, Xiu Gong Gao, Kuppusamy Ilangovan, Vincent V. Suzara, Nejat Düzgüneş, and V. Renugopalakrishnan

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The Th1 immune response against HIV-1 Gag p24-derived peptides in mice expressing HLA-A02.01 and HLA-DR1, Anthony Pajot, Aurelie Schnuriger, Arnaud Moris, Audrey Rodallec, David M. Ojcius, Brigitte Austran, Francois A. Lemonnier, and Yu-Chun Lone

Liposomes inhbit uptake of bitter tastants into cultured epithelial cells, T. Preston, Diana Flasher, Shlomo Nir, and Nejat Düzgüneş

Murine survivin promoter-driven gene expression in cancer and non-tumor cells, Christopher Spain, Nathan Overlid, F. Li, Nejat Düzgüneş, and Krystyna Konopka

Targeting gene transfer vectors to oral squamous cell carcinoma cells, A. Streeter, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

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Correlation between infections with different genotypes of human cytomegalovirus and Epstein-Barr virus in subgingival samples and the periodontal status of patients, Yan-Min Wu, Jie Yan, David M. Ojcius, Li-Li Chen, Zhi-Yuan Gu, and Jian-Peng Pan

Survivin promoter-driven gene expression in human oral cancer cells, Allison Yen, Nathan Overlid, F. Li, Nejat Düzgüneş, and Krystyna Konopka

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Host-cell survival and death during Chlamydia infection, Songmin Ying, Matthew A. Pettengill, David M. Ojcius, and Georg Hacker

Submissions from 2006

Rap1 Activators are Novel Anti-Angiogenic Agents, Robert C. Doebele, Mark W. Lingen, Jacques E. Nör, Diane June Rodi, Jia Hong, Benjamin David Zeitlin, Wei-Jen Tang, and Marsha Rich Rosner

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Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds, Sylvie M. Guichard, Roderick W. Else, Benjamin David Zeitlin, Morwenna Muir, Michael Dodds, Heinz-Herbert Fiebig, Peter J. Sadler, and Duncan I. Jodrell

Effect of prolonged budesonide therapy on IL-4, IL-5, and IL-10 in a murine model of asthma, Kameswari S. Konduri, Sandhya D. Nandedkar, S. Deenamsetty, D. A. Rickaby, and Nejat Düzgüneş

Cancer cell-specific luciferase expression driven by the human survivin promoter, Krystyna Konopka, Nathan Overlid, F. Li, and Nejat Düzgüneş

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Serum decreases the size of metafectene- and GeneJammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells, Krystyna Konopka, Nathan Overlid, Anitha C. Nagaraj, and Nejat Düzgüneş

Radiographic effects of three radiopaque substances when added to a potential endodontic repair cement, M. Maguollo, Ana Carolina Morandini, A. C. F. Bodanezi, E. A. Bortoluzzi, and C. M. Bramante

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Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X(7)-associated pore or channel formation, Christiane M. Monteiro da Cruz, Ana Lucia Marques Ventura, Julieta Schachter, Helio Miranda Costa-Junior, Hercules Antonio da Silva Souza, Fernanda Ramos Gomes, Robson Coutinho-Silva, David M. Ojcius, and Pedro M. Persechini

Treatment of anterior open bite with cleft and chincup: study of dentoalveolar and soft tissue effects, Ana Carolina Morandini, F. C. Torres, Renato Rodrigues de Almeida, R. R. Almeida-Pedrin, F. P. Ferreira, Marcio Rodrigues de Almeida, J. F. C. Henriques, and M. Maguollo

Efficacy of prolonged budesonide therapy on inflammation and airway reactivity in a murine model of asthma, Sandhya D. Nandedkar, Kameswari S. Konduri, S. Deenamsetty, D. A. Rickaby, and Nejat Düzgüneş

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Identification of novel HLA-DR1-restricted epitopes from the hepatitis B virus envelope protein in mice expressing HLA-DR1 and vaccinated human subjects, Anthony Pajot, Marie-Louise Michel, Maryline Mancini-Bourgine, Marie-Noelle Ungeheuer, David M. Ojcius, Qiang Deng, Francois A. Lemonnier, and Yu-Chun Lone

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Activation of iCaspase-9 in neovessels inhibits oral tumor progression, Matthew Stephen Pinsky, Wenying Song, Zhihong Dong, Kristy Warner, Benjamin David Zeitlin, Elisabeta Karl, Daniel E. Hall, and Jacques E. Nör

Action of a topic metronidazole 25% gel in gingival indices , bleeding and probing depth in children with Type 1 Diabetes Mellitus, M. P. Prestes, Maria Aparecida Andrade Moreira Machado, Carlos Ferreira Santos, V. T. Sakai, and Ana Carolina Morandini

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Antitumoral activity of transferrin-lipoplexes carrying the IL-12 gene in the treatment of colon cancer, Conchita Tros De Ilarduya, Maria Buñuales, Cheng Qian, and Nejat Düzgüneş

A pathogen with two personalities: death and survival during infection with Chlamydia, Philippe Verbeke, Lynn Stahl, Thomas Jungas, Christiane Delarbre, and David M. Ojcius

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Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival, Philippe Verbeke, Lynn Welter-Stahl, S. Ying, J. Hansen, Georg Hacker, Toni Darville, and David M. Ojcius

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Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum, L. Welter-Stahl, David M. Ojcius, J. Viala, S. Girardin, W. Liu, C. Delarbre, D. Philpott, K. A. Kelley, and T. Darville

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In vitro investigation on force degradation of elastomeric chains, Nan (Tori) Xiao and Ding Zhang

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Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells, Özlem Yilmaz, Philippe Verbeke, Richard J. Lamont, and David M. Ojcius

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Characterization of host cell death induced by Chlamydia trachomatis, Songmin Ying, Silke F. Fischer, Matthew A. Pettengill, Debye Conte, Stefan A. Paschen, David M. Ojcius, and Georg Hacker

Serum-resistant gene delivery to murine squamous cell carcinoma cells, Mark Young, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

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Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2, Benjamin David Zeitlin, Esther Joo, Zhihong Dong, Kristy Warner, Guo-Liang Wang, Zaneta Nikolovska-Coleska, Shaomeng Wang, and Jacques E. Nör

Submissions from 2005

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A role for mitogen-activated protein kinase (Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death, Rodolphe Auger, Iris Motta, Karim Benihoud, David M. Ojcius, and Jean M. Kanellopoulos

Infection of oral epithelial cells by Porphyromonas gingivalis: A DNA microarray analysis of host cell gene expression, K. Bracy, Nathan Overlid, V. Suzara, and Nejat Düzgüneş

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Association between coinfection of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Treponema denticola and periodontal tissue destruction in chronic periodontitis, L. L. Chen, Y. M. Wu, J. Yan, W. L. Sun, Y. Z. Sun, and David M. Ojcius

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Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages, Robson Coutinho-Silva, David M. Ojcius, D. C. Górecki, Pedro M. Persechini, R. C. Bisaggio, A. N. Mendes, J. Marks, G. Burnstock, and P. M. Dunn

P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation, Robson Coutinho-Silva, Lynn Stahl, K. K. Cheung, N. E. de Campus, C. de Oliveira Souza, David M. Ojcius, and G. Burnstock

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Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines, Elisabeta Karl, Kristy Anne Warner, Benjamin David Zeitlin, Tomoatsu Kaneko, Lindsey Elizabeth Wurtzel, Taocong Jin, Jia Chang, Shaomeng Wang, Cun-Yu Wang, Robert M. Strieter, Gabriel Nunez, and Jacques E. Nör

Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: Application to HSV-tk/ganciclovir-mediated cytotoxicity, Krystyna Konopka, Basma Fallah, Jomarie Monzon-Duller, Nathan Overlid, and Nejat Düzgüneş

Efficient, serum-resistant transfection of murine squamous cell carcinoma cells by Metafectene and GeneJammer: Application to HSV-tk/ganciclovir gene therapy, Krystyna Konopka, Nathan Overlid, and Nejat Düzgüneş

The Dental Health Program for the Brazilian Family, Ana Carolina Morandini, C. O. Cunha, F. Yanikian, and N. E. Tomita

Cryotherapy in the treatment of papillary hyperplasia of the palate, Ana Carolina Morandini, M. Maguollo, D. Albuquerque, F. M. Amado, and C. R. G. Xavier

Periodontal disease as a risk factor for development of premature and low birth weight babies, Ana Carolina Morandini, M. Maguollo, and C. R. Fujiwara

Multiple dysplasic unerupted teeth: case report, Ana Carolina Morandini, M. Maguollo, M. Lima, R. Teixeira, and D. Albuquerque

Dental transplantation, Ana Carolina Morandini, M. Maguollo, and C. Marzola

20 years of PET FOB USP, Ana Carolina Morandini and Carlos Ferreira Santos

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Chlamydia trachomatis induces expression of IFN-g-inducible protein 10 and IFN-b independent of TLR2 and TLR4, but largely dependent on MyD88, Uma M. Nagarajan, David M. Ojcius, Lynn Stahl, Roger G. Rank, and Toni Darville

Can chlamydia be stopped?, David M. Ojcius, Toni Darville, and Patrik M. Bavoil

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Cationic liposomes for gene delivery, Sérgio Simões, Ana Filipe, Henrique Faneca, Miguel Mano, Nuno Penacho, Nejat Düzgüneş, and Maria C. Pedroso De Lima

Gene delivery to murine oral cancer cells in the presence of mouse serum: Application to HSV-tk/ganciclovir suicide gene therapy, Mark Young, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

Gene therapy for oral cancer: efficient delivery of a 'suicide gene' to murine oral cancer cells in physiological milieu., Mark Young, Nathan Overlid, Krystyna Konopka, and Nejat Düzgüneş

TW-37, a novel molecular inhibitor of BCL2 with anti-angiogenic properties, Benjamin David Zeitlin, Esther Joo, Guo-Liang Wang, Shaomeng Wang, and Jacques E. Nör

Submissions from 2004

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Risk factors for periodontitis in HIV+ patients, Tamer Alpagot, Nejat Düzgüneş, Larry F. Wolff, and Aaaron Lee

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Chlamydia, Robert Belland, David M. Ojcius, and Gerald I. Byrne

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Chlamydia and apoptosis: life and death decisions of an intracellular pathogen, Gerald I. Byrne and David M. Ojcius