Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
Volume
52
Issue
7
DOI
10.1128/AAC.00785-07
First Page
2660
Last Page
2662
Publication Date
4-14-2008
Abstract
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Recommended Citation
Abdul-Sater, A. A.,
Ojcius, D. M.,
&
Meyer, M. P.
(2008).
Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity.
Antimicrobial Agents and Chemotherapy, 52(7), 2660–2662.
DOI: 10.1128/AAC.00785-07
https://scholarlycommons.pacific.edu/dugoni-facarticles/198
