Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Department
Biomedical Sciences
Document Type
Article
Publication Title
Nature Neuroscience
ISSN
1546-1726
Volume
13
Issue
1
DOI
10.1038/nn.2459
First Page
22
Last Page
24
Publication Date
1-1-2010
Abstract
In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.
Recommended Citation
Xu, J.,
Xiao, N.,
&
Xia, J.
(2010).
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1.
Nature Neuroscience, 13(1), 22–24.
DOI: 10.1038/nn.2459
https://scholarlycommons.pacific.edu/dugoni-facarticles/244
