Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule
ORCID
Dr. Benjamin D. Zeitlin: 0000-0003-0110-0188
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Department
Biomedical Sciences
Document Type
Contribution to Book
Book Title
Small-Molecule Inhibitors of Protein-Protein Interactions
Editor(s)
Lyubomir Vassilev and David Fry
Description
Cancer has a complex etiology and displays a wide range of cellular escape pathways that allow it to circumvent treatment. Signaling molecules functionally downstream of the circumvented pathways, and particularly at checkpoints where several of these pathways intersect, provide valuable targets for the development of novel anti-cancer drugs. Bcl-2, a pro-survival signaling molecule, is one such protein. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins. The review focuses on the compounds with most available data within the literature and discusses both the anti-cancer and the recently unveiled anti-angiogenic potential of this new class of drugs.
Buy Link
https://link.springer.com/chapter/10.1007%2F82_2010_109
ISBN
978-3-642-17083-6
Publication Date
1-1-2011
Publisher
Springer
First Page
115
Last Page
137
Disciplines
Dentistry | Medicine and Health Sciences
Recommended Citation
Zeitlin, Benjamin David and Nör, Jacques E., "Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule" (2011). All Dugoni School of Dentistry Faculty Books and Book Chapters. 11.
https://scholarlycommons.pacific.edu/dugoni-facbooks/11
Comments
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 348)