A selection of scholarship from faculty members of the Department of Biomedical Sciences (BMS) at Arthur A. Dugoni School of Dentistry, University of the Pacific.

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Submissions from 2017

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Glial cell derived neurotrophic factor promotes dental pulp stem cell migration, Nan (Tori) Xiao, Wei Ye Yu, and Dawei Liu

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MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice, Laxmi Yeruva, S. Pouncey, Michael R. Eledge, Sudeepa Bhattacharya, Chunqiao Luo, Erin W. Weatherford, David M. Ojcius, and Roger G. Rank

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Blueberry Fruit Nanovesicles, Ryan Yu and Benjamin David Zeitlin

VoiceThread promotes student engagement in discussion by increasing flexibility, Xiao Xi Yu, Ruidan Ma, Der Thor, and Nan (Tori) Xiao

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Effects of Lipoteichoic Acid and Lipopolysaccharide on SHED, Benjamin David Zeitlin, Ryan Yu, and Takahiro Chino

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Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells, Yang Zeng, Bingrun Liu, Marie-Therese Rubio, Xinyue Wang, David M. Ojcius, Ruoping Tang, Antoine Durrbach, Zhitao Ru, Yusen Zhou, and Yu-Chun Lone

Submissions from 2016

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Purinergic signaling during Porphyromonas gingivalis infection, Cássio Luiz Coutinho Almeida-da-Silva, Ana Carolina Morandini, David M. Ojcius, Robson Coutinho-Silva, and Henning Ulrich

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Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome, Kalina Atanasova, Jungnam Lee, JoAnn Roberts, Kyulim Lee, David M. Ojcius, and Özlem Yilmaz

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Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1, F. Q. Bui, L. Johnson, JoAnn Roberts, S. C. Hung, J. Lee, K. R. Atanasova, P. R. Huang, Özlem Yilmaz, and David M. Ojcius

Modulation of host immune response by Bacteroides fragilis polysaccharides: a review of recent observations, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M. Ojcius, W. F. Lai, Chia-Chen Lu, Yun-Fei Ko, John Ding-E. Young, and Hsin-Chih Lai

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Modulation of host immune response by Bacteroides fragilis polysaccharides: a review of recent observations, C. J. Chang, C. S. Lin, J. Martel, David M. Ojcius, W. F. Lai, C. C. Lu, Y. F. Ko, J. D. Young, and H. C. Lai

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Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections, M. F. Chen, K. F. Weng, S. Y. Huang, Y. C. Liu, S. N. Tseng, David M. Ojcius, and S. R. Shih

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A nonviral vector with transfection activity comparable with adenoviral transduction, Jennifer Cheung, Takahiro Chino, Cynthia Co, Krystyna Konopka, and Nejat Düzgüneş

Photodynamic therapy of oral cancer with liposomal zinc phthalocyanine, Jennifer Cheung, D. Furukawa, R. Pandez, Jaroslaw Piskorz, Nejat Düzgüneş, and Krystyna Konopka

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TransfeX-Mediated HSV-tk/ganciclovir suicide gene therapy in HeLa cervical carcinoma and HSC-3, FaDu, and H357 oral cancer cells, Jennifer Cheung, Krystyna Konopka, and Nejat Düzgüneş

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Toll-like receptor (TLR) expression profile and biological effects of selective TLR-ligands on stem cells from human exfoliated deciduous teeth, Poster#2424, Takahiro Chino, Ryan Yu, and Benjamin David Zeitlin

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Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis, I-Che Chung, Chun-Nan OuYang, Sheng-Ning Yuan, Hsin-Pai P. Li, Jeng-Ting Chen, Hui-Ru Shieh, Yu-Jen Chen, David M. Ojcius, Ching-Liang Chu, Jau-Song Yu, Yu-Sun Chang, and Lih-Chyang Chen

Cationic porphyrin-mediated photodynamic inactivation of Candida biofilms and the effect of miconazole, A. Davies, Senait Gebremedhin, M. Yee, R. J. Padilla, Nejat Düzgüneş, K. Konopka, and Barbara Dorocka-Bobkowska

Effect of Glial cell derived neurotrophic factor (GDNF) on migration and survival of head and neck squamous cell carcinoma (HNSCC), Qian He, Hongbin Cao, Nan (Tori) Xiao, and Quynh-Thu Le

Growth of P. gingivalis and S. mutans in high extracellular calcium concentrations, Kevin Kai, Andrew LaFlamme, Nan (Tori) Xiao, and Der Thor

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An iron detection system determines bacterial swarming initiation and biofilm formation, Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tseng-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M. Ojcius, Hsin-Chih Lai, and John Ding-E. Young

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Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity, Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai, and John Ding-E. Young

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Alternative functions for the multifarious inflammasome, Jan Martel, Hsin-Chih Lai, Yun-Fei Ko, John Ding-E. Young, and David M. Ojcius

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Alternative functions for the multifarious inflammasome, J. Martel, H. C. Lai, Y. F. Ko, J. D. Young, and David M. Ojcius

Comparison of expression of the GDNF family of neurotrophic factors in dental pulp stem cells within primary and permanent teeth, Kamille Mercado and Nan (Tori) Xiao

Comparison of expression of the GDNF family of neurotrophic factors in dental pulp stem cells within primary and permanent teeth, Kamille Mercado and Nan (Tori) Xiao

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Dendrimeric Sulfanyl Porphyrazines: Synthesis, Physico-Chemical Characterization, and Biological Activity for Potential Applications in Photodynamic Therapy, Dariusz T. Mlynarczyk, Sebastian Lijewski, Michal Falkowski, Jaroslaw Piskorz, Wojciech Szczolko, Lukasz Sobotta, Magdalena Stolarska, Lukasz Popenda, Stefan Jurga, Krystyna Konopka, Nejat Düzgüneş, Jadwiga Mielcarek, and Tomasz Goslinski

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Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling, Ana Carolina Morandini, Carlos Ferreira Santos, and Özlem Yilmaz

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Hepatitis C virus frameshift/alternate reading frame protein suppresses interferon responses mediated by pattern recognition receptor retinoic-acid-inducible gene-I, Seung Bum Park, Scott Seronello, Wasima Mayer, and David M. Ojcius

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Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae, M. A. Pettengill, A. A. Sater, R. Coutinho-Silva, and David M. Ojcius

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Danger signals, inflammasomes, and the intricate lives of chlamydiae, Matthew A. Pettengill, Ali A. Abdul-Sater, Robson Coutinho-Silva, and David M. Ojcius

Moisture-seeking behavior may correlate with degree of radiation-induced xerostomia in mice, A. Rameau, Y. Zeidan, J. Saiki, Nan (Tori) Xiao, Quynh-Thu Le, and D. Sirjani

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Is the inflammasome relevant for epithelial cell function?, Patricia T. Santana, Jan Martel, Hsin-Chih Lai, Jean-Luc Perfettini, Jean M. Kanellopoulos, John Ding-E. Young, Robson Coutinho-Silva, and David M. Ojcius

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Is the inflammasome relevant for epithelial cell function, P. T. Santana, J. Martel, H. C. Lai, J. L. Perfettini, J. M. Kanellopoulos, J. D. Young, R. Coutinho-Silva, and David M. Ojcius

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Purinergic signaling during Porphyromonas gingivalis infection, C. Silva; A. C. Morandini; David M. Ojcius; and R. Coutinho-Silva,

Invited Speaker, Nan (Tori) Xiao

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Neurotrophic factors: promising candidates in tissue regeneration, Nan (Tori) Xiao

Stem Cell Therapy from bench side to bedside, Nan (Tori) Xiao

The Role of Neurotrophic factors in Dental Pulp Stem Cell, Nan (Tori) Xiao

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Neurotrophic Factors and Their Potential Applications in Tissue Regeneration, Nan (Tori) Xiao and Quynh-Thu Le

Phototoxicity of Liposomal Zn- and Al-phthalocyanine Against Cervical and Oral Squamous Cell Carcinoma Cells In Vitro, Jason Young, Michael Yee, Hayoung Kim, Jennifer Cheung, Takahiro Chino, Nejat Düzgüneş, and Krystyna Konopka

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Botulinum Toxin Confers Radioprotection in Murine Salivary Glands, Youssef H. Zeidan, Nan (Tori) Xiao, Hongbin Cao, Christina S. Kong, Quynh-Thu Le, and Davud Sirjani

Submissions from 2015

Role of Nucleoside Diphosphate Kinase in Porphyromonas gingivalis infection, Cássio Luiz Coutinho Almeida-da-Silva, G. C. Rocha, Erivan Schnaider Ramos-Junior, Ana Carolina Morandini, A. C. Scharfstein, Özlem Yilmaz, David M. Ojcius, and Robson Coutinho-Silva

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Porphyromonas gingivalis’ Nucleoside Diphosphate Kinase Contributes to IL-1β Production and Secretion in Macrophages, Cássio Luiz Coutinho Almeida-da-Silva, G. Rocha, R. Ramos-Junior, Ana Carolina Morandini, Julio Scharfstein, Özlem Yilmaz, David M. Ojcius, and Robson Coutinho-Silva

Role of Nucleoside-Diphosphate Kinase during Porphyromonas gingivalis infection, Cássio Luiz Coutinho Almeida-da-Silva, G. Rocha, R. Ramos-Junior, Julio Scharfstein, Ana Carolina Morandini, Özlem Yilmaz, David M. Ojcius, and Robson Coutinho-Silva

Stimulation and repression of cancer development by caveolae and nitric oxide, C. M. Blouin and David M. Ojcius

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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John Ding-E. Young, and Hsin-Chih Lai

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Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid, Hong-Hu Chen, Ai-Hua Sun, David M. Ojcius, Wei-Lin Hu, Yu-Mei Ge, Xu'ai Lin, Lan-Juan Li, Jian-Ping Pan, and Jie Yan

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A non-viral vector with transfection activity comparable to adenoviral transduction, Jennifer Cheung, C. Co, Krystyna Konopka, Takahiro Chino, and Nejat Düzgüneş

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TransfeX and TransIT-LT1 mediated gene delivery to cervical and oral squamous cell carcinoma cells, Jennifer Cheung, Krystyna Konopka, Takahiro Chino, and Nejat Düzgüneş

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Intracellular bacterial pathogens: a reemerging field of research rich with breakthroughs and opportunities, Gilbert Greub, Chantal P. Bleeker-Rovers, Jason Carlyon, Pierre-Edouard Fournier, David M. Ojcius, and Mirja Puolakkainen

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MERS – a cautionary tale, Sophia Hafner and David M. Ojcius

Sex differences in metabolic and pathologic responses to dietary fructose in rodent model, Xiaoyuan Han, W. Owumi, O. Hammam, C. Chien, and Linda M. Dairiki Shortliffe

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Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo, Tsung-Teng Huang, Hsin-Chih Lai, Yun-Fei Ko, David M. Ojcius, Ying-Wei Lan, Jan Martel, John Ding-E. Young, and Kowit-Yu Chong

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Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase, Larry Johnson, Kalina R. Atanasova, Phuong Q. Bui, Jungnam Lee, Shu-Chen Hung, Özlem Yilmaz, and David M. Ojcius

Introduction to miniseries on DNA and cancer, J. M. Kanellopoulos and David M. Ojcius

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Effects of periodontal therapy on white blood cell count and levels of transforming growth factor beta in serum of subjects with severe periodontitis, A. C. E. Leite, V. M. A. Carneiro, Ana Carolina Morandini, Erivan Schnaider Ramos-Junior, and M. C. M. Guimarães

Periodontal Therapy on Leukocytes Count and TGF-β Levels, Anne Carolina E. Leite, Ana Carolina Morandini, Erivan Schnaider Ramos-Junior, Valéria M. A. Carneiro, and Maria do Carmo Machado Guimaraes

Mushrooms – from cuisine to clinic, Jan Martel, David M. Ojcius, Hsin-Chih Lai, and John Ding-E. Young

Microbiome et santé, J. Martel, David M. Ojcius, C. J. Chang, Y. F. Ko, Hsin-Chih Lai, and John Ding-E Young

The histone deasetylase HDAC1 expression in human periodontitis – preliminary results, Ana Carolina Morandini, E. J. Franco, Erivan Schnaider Ramos-Junior, A. A. Pedra, F. B. Andrade, and Carlos Ferreira Santos

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A dual role for P2X7 receptor during Porphyromonas gingivalis infection, E. S. Ramos-Junior, Ana Carolina Morandini, Cassio Almeida-da-Silva, E. J. Franco, J. Potempa, K. A. Nguyen, A. C. Oliveira, D. S. Zamboni, David M. Ojcius, J. Scharfstein, and Robson Coutinho-Silva

Role of P2X7 receptor during Porphyromonas gingivalis infection, G. C. Rocha, C. L. C. Almeida-da-Silva, Erivan Schnaider Ramos-Junior, Ana Carolina Morandini, Julio Scharfstein, Özlem Yilmaz, David M. Ojcius, and Robson Coutinho-Silva

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Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue, Carlos Ferreira Santos, Ana Carolina Morandini, Thiago José Dionísio, Flávio A. Faria, Marta C. Lima, Caio M. Figueiredo, Bella L. Colombini-Ishikiriama, Carla Renata Sipert, Rubens P. Maciel, Ana P. Akashi, Gabriela P. Souza, Gustavo P. Garlet, Camila O. Rodini, Sandra L. Amaral, Christiane Becari, Maria C. Salgado, Eduardo B. Oliveira, Isaac Matus, Daniela N. Didier, and Andrew S. Greene

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Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages leading to the release of pro-inflammatory cytokines, Bruce J. Shenker, David M. Ojcius, Lisa P. Walker, Ali Zekavat, Monika Damek Scuron, and Kathleen Boesze-Battaglia

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Dietary fructose in pregnancy induces hyperglycemia, hypertension, and pathologic kidney and liver changes in a rodent model, Linda M. Dairiki Shortliffe, Olfat Hammam, Xiaoyuan Han, Erik Kouba, Philip S. Tsao, and Bingyin Wang

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Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles, Tsui-Yin Wong, Hsin-Hsin Peng, Cheng-Yeu Wu, Jan Martel, David M. Ojcius, Fu-Yung Hsu, and John Ding-E. Young

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Detection and characterization of mineralo-organic nanoparticles in human kidneys, Tsui-Yin Wong, Cheng-Yeu Wu, Jan Martel, Cheng-Wei Lin, Fu-Yung Hsu, David M. Ojcius, Paul Y. Lin, and John Ding-E. Young

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The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors, Pedro Xavier-Elsas, Cassio Luiz Coutinho Almeida-Da-Silva, Bruno Marques Vieira, and Daniela Masid-de-Brito

Invited Speaker, Nan (Tori) Xiao

Neurotrophic factor GDNF promotes survival of salivary gland stem cells, Nan (Tori) Xiao, Yuan Lin, and Hongbin Cao

Neurotrophic factor GDNF promotes survival of salivary gland stem cells, Nan (Tori) Xiao, Yuan Lin, and Hongbin Cao

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A new frontier: oral microbes without borders, Özlem Yilmaz and David M. Ojcius

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The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy, Lihua Ying, Margaux Becard, Deirdre Lyell, Xiaoyuan Han, Linda Shortliffe, Cristiana Iosef Husted, Cristina M. Alvira, and David N. Cornfield

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Concept mapping for enhanced comprehension in pharmacology, Benjamin David Zeitlin and Homayon Asadi

A practical comparison of exosome isolation kits for primary endothelial and monocytic THP-1 cell samples with low working volumes, Benjamin David Zeitlin, Osamu Iwamoto, Wei Ye Yu, and Takahiro Chino

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Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope, Ye Zhu, Janina Jiang, Najwane Said-Sadier, Gale Boxx, Cheryl Champion, Ashley Tetlow, Valerie A. Kickhoefer, Leonard H. Rome, David M. Ojcius, and Kathleen A. Kelly

Submissions from 2014

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TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans, Mufadhal Al-Kuhlani, James Rothchild, Sukumar Pal, Luis M. de la Maza, Sander Ouberg, Servaas A. Morré, Deborah Dean, and David M. Ojcius

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Palatal mucosa derived fibroblasts present an adaptive behavior regarding cytokine secretion when grafted onto the gingival margin, Fabíola Pontes Azevedo, Ana Carolina Morandini, Carla Renata Sipert, Thiago José Dionísio, Carlos Ferreira Santos, Carla Andreotti Damante, Maria Lúcia Rubo de Rezende, Adriana Campos Passanezi Sant'ana, Sebastião Luiz Aguiar Greghi, and

Broadly neutralizing anti-HIV antibodies do not Inhibit HIV-mediated cell-cell fusion, Deborah Chau, Michael Yee, Krystyna Konopka, and Nejat Düzgüneş

Miconazole activity against Candida biofilms developed on acrylic discs, Senait Gebremedhin, Barbara Dorocka-Bobkowska, M. Prylinski, Krystyna Konopka, and Nejat Düzgüneş

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Gene delivery to cancer cells with Metafectene and its Derivatives: Nanoparticle tracking analysis of lipoplexes, Senait Gebremedhin, Stephen Koons, William Bernt, and Nejat Düzgüneş

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Gene delivery to carcinoma cells via novel non-viral vectors: Nanoparticle tracking analysis and suicide gene therapy, Senait Gebremedhin, Aruna Singh, Stephen Koons, William Bernt, Krystyna Konopka, and Nejat Düzgüneş

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Is the hoopla over CPAF justified?, Georg Hacker, Dagmar Heuer, and David M. Ojcius

Sexual dimorphism in aortic endothelial function of Zucker diabetic fatty rats: Possible involvement of superoxide production, Xiaoyuan Han, Sonali Shaligram, Leigh Anderson, and Roshanak Rahimian

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cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophages, Tsung-Teng Huang, Hsin-Chih Lai, Young-Bin Chen, Lih-Geeng Chen, Yi-Hui Wu, Yun-Fei Kourilsky, Chia-Chen Lu, Chih-Jung Chang, Cheng-Yeu Wu, Jan Martel, David M. Ojcius, Kowit-Yu Chong, and John Ding-E. Young

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The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome, Tsung-Teng Huang, Sian-Pu Wu, Kowit-Yu Chong, David M. Ojcius, Yun-Fei Ko, Yi-Hui Wu, Cheng-Yeu Wu, Chia-Chen Lu, Jan Martel, John Ding-E. Young, and Hsin-Chih Lai

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Valley fever: danger lurking in a dust cloud, Larry Johnson, Erin M. Gaab, Javier Sanchez, Phuong Q. Bui, Clarissa J. Nobile, Katrina K. Hoyer, Michael W. Peterson, and David M. Ojcius

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Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species, Kokouvi Kassegne, Weilin Hu, David M. Ojcius, Dexter Sun, Yu-Mei Ge, Jinfang Zhao, X. Frank Yang, Lanjuan Li, and Jie Yan

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Liposomal Zn- and Al-phthalocyanine enhance photodynamic therapy of oral cancer, Hayoung Kim, Michael Yee, Paulina Skupin-Mrugalska, and Nejat Düzgüneş

Inflammasomes and danger signals in the immune system, Hsin-Chih Lai, Mufadhal Al-Kuhlani, David M. Ojcius, and Matthew A. Pettengill

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease, C. S. Lin, Chih-Jung Chang, Chau-Ching Liu, Jan Martel, David M. Ojcius, Yun-Fei Kourilsky, John Ding-E. Young, and Hsin-Chih Lai

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The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection, Sue-Jane Lin, Ming Lo, Rei-Lin Kuo, Shin-Ru Shih, David M. Ojcius, Jean Lu, Chien-Kuo Lee, Hui-Chen Chen, Meei Yun Lin, Chuen-Miin Leu, Chia-Ni Lin, and Ching-Hwa Tsai

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Methyl-accepting chemotaxis proteins 3 and 4 are responsible for Campylobacter jejuni chemotaxis and jejuna colonization in mice in response to sodium deoxycholate, Zhifeng Li, Hongqiang Lou, David M. Ojcius, Aihua Sun, Dexter Sun, Jinfang Zhao, Xu'ai Lin, and Jie Yan

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NK cells kill mycobacteria directly by releasing perforin and granulysin, Chia-Chen Lu, Ting-Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, John Ding-E. Young, and Hsin-Chih Lai

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Essential roles of endogenous glucocorticoids and TNF/TNFR1 in promoting bone-marrow eosinopoiesis in ovalbumin-sensitized, airway-challenged mice, Daniela Masid-De-Brito, Pedro Xavier-Elsas, Ricardo Alves Luz, Túlio Queto, Cassio Luiz Coutinho Almeida-Da-Silva, Rodrigo Soares Lopes, Bruno Marques Vieira, and Maria Ignez Capella Gaspar-Elsas

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Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion, Ana Carolina Morandini, E. S. Ramos-Junior, J. Potempo, K. A. Nguyen, A. C. Oliveira, M. Bellio, David M. Ojcius, J. Scharfstein, and Robson Coutinho-Silva

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The role of P2X7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases, Ana Carolina Morandini, Luiz Eduardo Baggio Savio, and Robson Coutinho-Silva

Active Methodologies in Teaching: demonstrating dental biofilm control, J. F. Nunes, Anne Carolina E. Leite, E. J. Franco, Ana Carolina Morandini, and R. L. R. Passos

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Another year of microbial pathogens and the host immune response, David M. Ojcius