Inflammasomes and danger signals in the immune system

Authors

Hsin-Chih Lai
Mufadhal Al-Kuhlani
David M. Ojcius, University of the PacificFollow
Matthew A. Pettengill

ORCID

Dr. David Ojcius: 0000-0003-1461-4495

Files

Department

Biomedical Sciences

Document Type

Contribution to Book

Book Title

Reference Module in Biomedical Research

Editor(s)

Michael J. Caplan

Description

The innate immune system has evolved to recognize both pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), which represent conserved microbial structures or generic markers of stress or damage, respectively, and to generate an appropriate response. One such response is the production of the critical cytokines interleukin-1β and interleukin-18, which follows incorporation of PAMP and DAMP signals, and requires the activation of protein complexes termed inflammasomes to generate mature cytokines.

Buy Link

http://doi.org/10.1016/B978-0-12-801238-3.00106-9

Find in WorldCat

https://www.worldcat.org/title/reference-module-in-biomedical-research/oclc/902812782&referer=brief_results

ISBN

978-0-12-801238-3

Publication Date

1-1-2014

Publisher

Elsevier

City

Amsterdam, Netherlands

Keywords

ATP; Caspase; DAMP; HMGB1; Immunology; Inflammasome; Inflammation; Interleukin-1β; NLRP3; Nod-like receptors; PAMP; Toll-like receptors

Disciplines

Dentistry

Comments

DOI: 10.1016/B978-0-12-801238-3.00106-9

Recommended Citation

Lai, Hsin-Chih; Al-Kuhlani, Mufadhal; Ojcius, David M.; and Pettengill, Matthew A., "Inflammasomes and danger signals in the immune system" (2014). All Dugoni School of Dentistry Faculty Books and Book Chapters. 8.
https://scholarlycommons.pacific.edu/dugoni-facbooks/8