ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
PLoS One
ISSN
1932-6203
Volume
10
Issue
11
DOI
10.1371/journal.pone.0142881
First Page
1
Last Page
13
Publication Date
11-20-2015
Abstract
Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-β1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naïve T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-β1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-β1 and ATRA.
Recommended Citation
Chen, H.,
Sun, A.,
Ojcius, D. M.,
Hu, W.,
Ge, Y.,
Lin, X.,
Li, L.,
Pan, J.,
&
Yan, J.
(2015).
Eosinophils from murine lamina propria induce differentiation of naïve T cells into regulatory T cells via TGF-β1 and retinoic acid.
PLoS One, 10(11), 1–13.
DOI: 10.1371/journal.pone.0142881
https://scholarlycommons.pacific.edu/dugoni-facarticles/61
Included in
Biochemistry Commons, Immunity Commons, Immunology of Infectious Disease Commons, Medical Immunology Commons
Comments
Article e0142881