Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death

Authors

Benjamin David Zeitlin, University of the PacificFollow
Lee M. Ellis, University of TexasFollow
Jacques E. Nör, University of Michigan School of DentistryFollow

ORCiD

Dr. Benjamin D. Zeitlin: 0000-0003-0110-0188

Department

Biomedical Sciences

Document Type

Article

Publication Title

Clinical Cancer Research

ISSN

1078-0432

Volume

15

Issue

24

DOI

10.1158/1078-0432.CCR-09-2578

First Page

7453

Last Page

7455

Publication Date

Winter 12-15-2009

Abstract

Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5)

Recommended Citation

Zeitlin, B. D., Ellis, L. M., & Nör, J. E. (2009). Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death. Clinical Cancer Research, 15(24), 7453–7455. DOI: 10.1158/1078-0432.CCR-09-2578
https://scholarlycommons.pacific.edu/dugoni-facarticles/386