Cytolytic peptides and proteins: Is there a common structural motif?
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Trends in Biochemical Sciences
ISSN
0968-0004
Volume
16
DOI
10.1016/0968-0004(91)90090-I
First Page
225
Last Page
229
Publication Date
1-1-1991
Abstract
Pore-forming proteins or peptides (PFP) have now been isolated from a wide array of species ranging from humans to bacteria. A great number of these toxins lyse cells through a ‘barrel-stave’ mechanism, in which monomers of the toxin bind to and insert into the target membrane and then aggregate like barrel staves surrounding a central, water-filled pore. An evaluation of the secondary structures suggests that common secondary structures may be employed by most of these toxic PFP.
Recommended Citation
Ojcius, D. M.,
&
Young, J. D.
(1991).
Cytolytic peptides and proteins: Is there a common structural motif?.
Trends in Biochemical Sciences, 16, 225–229.
DOI: 10.1016/0968-0004(91)90090-I
https://scholarlycommons.pacific.edu/dugoni-facarticles/234
