Membrane action of synthetic N-terminal peptides of influenza virus hemagglutinin and its mutants
ORCiD
Nejat Düzgüneş: 0000-0001-6159-1391
Department
Biomedical Sciences
Document Type
Article
Publication Title
FEBS Letters
ISSN
0014-5793
Volume
227
Issue
2
DOI
10.1016/0014-5793(88)80879-2
First Page
110
Last Page
114
Publication Date
1-25-1988
Abstract
Synthetic peptides corresponding to the N-terminal of the cleaved hemagglutinin (HA2) of influenza virus induce an increase in conductance of planar phospholipid bilayers, and cause the release of encapsulated molecules from large unilamellar liposomes. Two mutant peptides, derived from hemagglutinins of mutant viruses with no or reduced fusion activity, do not alter the membrane conductance significantly. These observations support the hypothesis that influenza virus fuses with its target membrane by inserting the HA2 N-terminal into the membrane. © 1988.
Recommended Citation
Düzgüneş, N.,
&
Gambale, F.
(1988).
Membrane action of synthetic N-terminal peptides of influenza virus hemagglutinin and its mutants.
FEBS Letters, 227(2), 110–114.
DOI: 10.1016/0014-5793(88)80879-2
https://scholarlycommons.pacific.edu/dugoni-facarticles/626
