Molecular mechanisms of calcium-induced membrane fusion

ORCiD

Nejat Düzgüneş: 0000-0001-6159-1391

Department

Biomedical Sciences

Document Type

Article

Publication Title

Journal of Bioenergetics and Biomembranes

ISSN

0145-479X

Volume

22

Issue

2

DOI

10.1007/BF00762944

First Page

157

Last Page

179

Publication Date

4-1-1990

Abstract

We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have also discussed the roles of other cations, lipid phase transitions, long chain fatty acids and other fusogenic molecules. Finally, we have presented a simple molecular model for the mechanism of lipid membrane fusion, consistent with the experimental evidence and incorporating various elements proposed previously. © 1990 Plenum Publishing Corporation.

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