Comparison of the shape parameters of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes

Authors

Yan Sun, Dalian Institute of Chemical Physics Chinese Academy of Sciences
Xingju Yu, Dalian Institute of Chemical Physics Chinese Academy of Sciences
Yasuyuki Takaoka, Tokyo Denki University
Sho Ichi Oh-I, Tokyo Denki University
Nejat Düzgüneş, University of the Pacific Arthur A. Dugoni School of DentistryFollow
Sadao Hirota, Dalian Institute of Chemical Physics Chinese Academy of Sciences

ORCiD

Nejat Düzgüneş: 0000-0001-6159-1391

Department

Biomedical Sciences

Document Type

Article

Publication Title

Journal of Colloid and Interface Science

ISSN

0021-9797

Volume

276

Issue

2

DOI

10.1016/j.jcis.2004.03.064

First Page

317

Last Page

322

Publication Date

8-15-2004

Abstract

In this study, we used a rheological method to study the shape of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes. We introduced two kinds of anionic polyelectrolytes, sodium polygalacturonate (PGU) and sodium dextran sulfate (DSS), of varying size, as models for DNA. The prepared complexes were incubated under laminar flow conditions. The results show the same quantitative relation between the shape parameter of lipoplexes and the length of anionic polyelectrolytes, including DNA. The rheological behavior of PGU and DSS were similar to that of DNA. © 2004 Elsevier Inc. All rights reserved.

Recommended Citation

Sun, Y., Yu, X., Takaoka, Y., Oh-I, S., Düzgüneş, N., & Hirota, S. (2004). Comparison of the shape parameters of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes. Journal of Colloid and Interface Science, 276(2), 317–322. DOI: 10.1016/j.jcis.2004.03.064
https://scholarlycommons.pacific.edu/dugoni-facarticles/647