Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface

Authors

Colette Kanellopoulos-Langevin, Université Paris
Stephane M. Caucheteux, Université Paris
Philippe Verbeke, Université Paris
David M. Ojcius, Université ParisFollow

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Reproductive Biology and Endocrinology

ISSN

1477-7827

Volume

1

DOI

10.1186/1477-7827-1-121

First Page

121

Last Page

127

Publication Date

12-2-2003

Abstract

The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.

Recommended Citation

Kanellopoulos-Langevin, C., Caucheteux, S. M., Verbeke, P., & Ojcius, D. M. (2003). Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface. Reproductive Biology and Endocrinology, 1, 121–127. DOI: 10.1186/1477-7827-1-121
https://scholarlycommons.pacific.edu/dugoni-facarticles/182