Synthesis and preliminary in vitro activity of mono- and bis-1H- 1,2,3-triazole-tethered β-lactam-isatin conjugates against the human protozoal pathogen Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Medicinal Chemistry Research
Department
Biological Sciences
ISSN
Print: 1054-2523, Electronic: 1554-8120
Volume
23
Issue
16
DOI
10.1016/j.bmc.2015.04.075
First Page
5190
Last Page
5197
Publication Date
8-15-2015
Abstract
A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis. The structure activity studies (SAR) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of T. vaginalis at approximately 10 μM with no visual effect on mammalian cells at the same concentration.
Recommended Citation
Kumar, K.,
Liu, N.,
Yang, D.,
Na, D.,
Thompson, J.,
Wrischnik, L. A.,
Land, K. M.,
&
Kumar, V.
(2015).
Synthesis and preliminary in vitro activity of mono- and bis-1H- 1,2,3-triazole-tethered β-lactam-isatin conjugates against the human protozoal pathogen Trichomonas vaginalis.
Medicinal Chemistry Research, 23(16), 5190–5197.
DOI: 10.1016/j.bmc.2015.04.075
https://scholarlycommons.pacific.edu/cop-facarticles/800
