Title

Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis

Authors

Kewal Kumar, Guru Nanak Dev University
Nicole Liu, University of the Pacific
Donald Yang, University of the Pacific
John Thompson, University of the Pacific
Lisa A. Wrischnik, University of the PacificFollow
Kirkwood M. Land, University of the PacificFollow
Vipan Kumar, Guru Nanak Dev UniversityFollow

ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

Bioorganic & Medicinal Chemistry0968-0896

Department

Biological Sciences

ISSN

0968-0896

Volume

23

Issue

16

DOI

10.1016/j.bmc.2015.04.075

First Page

5190

Last Page

5197

Publication Date

8-1-2015

Abstract

A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis. The structure activity studies (SAR) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of T. vaginalis at approximately 10 μM with no visual effect on mammalian cells at the same concentration.

Recommended Citation

Kumar, K., Liu, N., Yang, D., Thompson, J., Wrischnik, L. A., Land, K. M., & Kumar, V. (2015). Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis. Bioorganic & Medicinal Chemistry0968-0896, 23(16), 5190–5197. DOI: 10.1016/j.bmc.2015.04.075
https://scholarlycommons.pacific.edu/cop-facarticles/779