AldoHcy Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture

Authors

Padraik J. Dornbush, University of the Pacific
Guillermo Vazquez-Anaya, University of the Pacific
Ajit Shokar, University of the Pacific
Saoly Benson, University of the Pacific
Magdelena Rapp, Florida International University
Stanislaw F. Wnuk, Florida International University
Lisa A. Wrischnik, University of the PacificFollow
Kirkwood M. Land, University of the PacificFollow

ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

Bioorganic and Medicinal Chemistry Letters

Department

Biological Sciences

ISSN

0960-894X

Volume

20

Issue

24

DOI

10.1016/j.bmcl.2010.10.014

First Page

7466

Last Page

7468

Publication Date

12-1-2010

Abstract

Trypanosoma brucei and Trichomonas vaginalis are both parasitic protozoans that are known to share many similar biochemical pathways. Aristeromycin, as well as 5′-iodovinyl and 5′-oxime analogues of adenosine, are potent inhibitors of AdoHcy hydrolase in T. brucei, an enzyme that catalyses the hydrolysis of AdoHcy to adenosine and l-homocysteine. To help determine the role of this enzyme in T. vaginalis, we have tested a library of 5′-modified adenosine derivatives, including 5′-deoxy-5′-(iodomethylene)-adenosine and related 6-N-cyclopropyl analogues. Our results indicate that these inhibitors are effective at inhibiting the growth of T. vaginalis, by as much as 95%

Recommended Citation

Dornbush, P. J., Vazquez-Anaya, G., Shokar, A., Benson, S., Rapp, M., Wnuk, S. F., Wrischnik, L. A., & Land, K. M. (2010). AldoHcy Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture. Bioorganic and Medicinal Chemistry Letters, 20(24), 7466–7468. DOI: 10.1016/j.bmcl.2010.10.014
https://scholarlycommons.pacific.edu/cop-facarticles/776