Title

Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis

Authors

Padraik J. Dornbush, University of the Pacific
Cynric H. Cho, University of the Pacific
Elizabeth Chang, University of the Pacific
Xu Lu, University of the Pacific
Wade A. Russu, University of the Pacific
Lisa A. Wrischnik, University of the PacificFollow
Kirkwood M. Land, University of the PacificFollow

ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

Bioorganic and Medicinal Chemistry Letters

Department

Biological Sciences

ISSN

0960-894X

Volume

20

Issue

17

DOI

10.1016/j.bmcl.2010.06.133

First Page

5299

Last Page

5301

Publication Date

9-1-2010

Abstract

Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective compound 15, inhibits growth of the organism by 66% and 69% on the two strains tested, T1 and G3, respectively.

Recommended Citation

Dornbush, P. J., Cho, C. H., Chang, E., Lu, X., Russu, W. A., Wrischnik, L. A., & Land, K. M. (2010). Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis. Bioorganic and Medicinal Chemistry Letters, 20(17), 5299–5301. DOI: 10.1016/j.bmcl.2010.06.133
https://scholarlycommons.pacific.edu/cop-facarticles/775