Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Bioorganic and Medicinal Chemistry Letters
Department
Biological Sciences
ISSN
0960-894X
Volume
20
Issue
17
DOI
10.1016/j.bmcl.2010.06.133
First Page
5299
Last Page
5301
Publication Date
9-1-2010
Abstract
Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective compound 15, inhibits growth of the organism by 66% and 69% on the two strains tested, T1 and G3, respectively.
Recommended Citation
Dornbush, P. J.,
Cho, C. H.,
Chang, E.,
Lu, X.,
Russu, W. A.,
Wrischnik, L. A.,
&
Land, K. M.
(2010).
Preliminary Studies of 3,4-Dichloroaniline Amides as Antiparasitic Agents: Structure Activity Analysis of a Compound Library in vitro Against Trichomonas vaginalis.
Bioorganic and Medicinal Chemistry Letters, 20(17), 5299–5301.
DOI: 10.1016/j.bmcl.2010.06.133
https://scholarlycommons.pacific.edu/cop-facarticles/775
