Physical Performance and Prediction of 2-5A Synthetase/RNaseL Antiviral Pathway Activity in Patients with Chronic Fatigue Syndrome

ORCID

J. Mark Van Ness: https://orcid.org/0000-0001-5902-8735

Document Type

Article

Publication Title

International Journal of In Vivo Research

Department

Health, Exercise, and Sport Sciences Department

Volume

16

Issue

3

Publication Date

1-1-2002

Abstract

The elevated RNase L enzyme activity observed in some Chronic Fatigue Syndrome (CFS) patients may be linked to the low exercise tolerance and functional impairment that typify this disease. The purpose of this investigation was to determine if specific indicators of physical performance can predict abnormal RNase L activity in CFS patients. Seventy-three CFS patients performed a graded exercise test to voluntary exhaustion. Forty-six patients had elevated RNase L levels. This measure was employed as the dependent variable in a discriminant function analysis, with peak V02, exercise duration and Karnofsky Performance Scores (KPS) serving as the independent variables. All three variables entered the single significant function (p < 0.001). The elevated RNase L group had a lower peak V02 and duration than the normal group, but a higher KPS. The results suggest that both exercise testing and the RNase L biomarker have potential to aid in the diagnosis of CFS.

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