Non-covalent calixarene–amino acid complexes formed by MALDI-MS
Document Type
Article
Publication Title
Journal of the American Society for Mass Spectrometry
Department
Chemistry
ISSN
1044-0305
Volume
13
Issue
8
DOI
10.1016/S1044-0305(02)00417-8
First Page
964
Last Page
974
Publication Date
8-1-2002
Abstract
Non-covalent inclusion complexes formed between amino acids and derivatized calix[6]arenes are observed in MALDI mass spectrometry. The methyl, ethyl, and propyl ester derivatives of calix[6]arene yielded amino acid complexes, while the smaller calix[4]arene analogs did not. Similarly the underivatized calix[6]arene and calix[4]arene did not produce complexes. Amino acid complexes were observed for nearly all 20 amino acids in time-of-flight (TOF) analysis. In Fourier transform mass spectrometry (FTMS) analysis, however, only the most basic amino acids arginine, histidine, and lysine formed stable adducts. The complexes were abundant under matrix-assisted laser desorption ionization (MALDI) conditions, which suggested favorable interactions between host and guest.
Recommended Citation
Stone, M. M.,
Franz, A. H.,
&
Lebrilla, C. B.
(2002).
Non-covalent calixarene–amino acid complexes formed by MALDI-MS.
Journal of the American Society for Mass Spectrometry, 13(8), 964–974.
DOI: 10.1016/S1044-0305(02)00417-8
https://scholarlycommons.pacific.edu/cop-facarticles/153
