Non-covalent calixarene–amino acid complexes formed by MALDI-MS

Authors

Michele M. Stone, University of California, Davis
Andreas H. Franz, University of California, DavisFollow
Carlito B. Lebrilla, University of California, DavisFollow

Document Type

Article

Publication Title

Journal of the American Society for Mass Spectrometry

Department

Chemistry

ISSN

1044-0305

Volume

13

Issue

8

DOI

10.1016/S1044-0305(02)00417-8

First Page

964

Last Page

974

Publication Date

8-1-2002

Abstract

Non-covalent inclusion complexes formed between amino acids and derivatized calix[6]arenes are observed in MALDI mass spectrometry. The methyl, ethyl, and propyl ester derivatives of calix[6]arene yielded amino acid complexes, while the smaller calix[4]arene analogs did not. Similarly the underivatized calix[6]arene and calix[4]arene did not produce complexes. Amino acid complexes were observed for nearly all 20 amino acids in time-of-flight (TOF) analysis. In Fourier transform mass spectrometry (FTMS) analysis, however, only the most basic amino acids arginine, histidine, and lysine formed stable adducts. The complexes were abundant under matrix-assisted laser desorption ionization (MALDI) conditions, which suggested favorable interactions between host and guest.

Recommended Citation

Stone, M. M., Franz, A. H., & Lebrilla, C. B. (2002). Non-covalent calixarene–amino acid complexes formed by MALDI-MS. Journal of the American Society for Mass Spectrometry, 13(8), 964–974. DOI: 10.1016/S1044-0305(02)00417-8
https://scholarlycommons.pacific.edu/cop-facarticles/153