Location
Classroom Building, Room 170, University of the Pacific, Stockton campus
Start Date
7-3-2017 12:00 PM
End Date
7-3-2017 1:00 PM
Description
Oviedo will be presenting his work on identifying the mechanisms of adult stem cell fate determination based on their topographical location in the adult body. Understanding stem cell fate determination is crucial because tissue repair and neoplastic growth are greater in anterior than in posterior regions of adult animals. Despite its critical implications for stem cell biology, carcinogenesis and regenerative medicine, this physiological phenomenon has remained overlooked. Recent findings from his group provide intriguing evidence implying DNA repair mechanisms and cellular signaling through post-translational modifications regulate stem cell fate decision depending on their topographical location in the adult body. We have identified organ-specific cues and evolutionarily conserved cellular signaling pathways that can be therapeutically exploited to control stem cell behavior and cellular transformation in the complexity of the adult body.
Host
Carlos Villalba-Galea
Included in
Biochemistry Commons, Cell and Developmental Biology Commons, Genetics Commons, Molecular Biology Commons, Physiology Commons
Molecular regulation of stem cell behavior during tissue repair and cancer formation
Classroom Building, Room 170, University of the Pacific, Stockton campus
Oviedo will be presenting his work on identifying the mechanisms of adult stem cell fate determination based on their topographical location in the adult body. Understanding stem cell fate determination is crucial because tissue repair and neoplastic growth are greater in anterior than in posterior regions of adult animals. Despite its critical implications for stem cell biology, carcinogenesis and regenerative medicine, this physiological phenomenon has remained overlooked. Recent findings from his group provide intriguing evidence implying DNA repair mechanisms and cellular signaling through post-translational modifications regulate stem cell fate decision depending on their topographical location in the adult body. We have identified organ-specific cues and evolutionarily conserved cellular signaling pathways that can be therapeutically exploited to control stem cell behavior and cellular transformation in the complexity of the adult body.
Presenter Bio
Nestor J. Oviedo, PhD, associate professor in the Department of Molecular & Cell Biology at UC Merced, will be the speaker for the next Science Seminar.
Click here to view the ResearchGate profile page of Dr. Oviedo