Novel 1→6- & 6→6-linked ester disaccharide analogs – synthesis and structural evaluation
Introduction/Abstract
Carbohydrate mimetics have been an active area of drug discovery, especially with regard to their potential use as glycosidase inhibitors. The ‘ester disaccharide’ motif is rare in nature, but has previously found use in a “redox glycosylation” approach to stereoselective glycosydic linkage, as well as in the development of trehalose-based compounds for drug delivery matrices. However, the basic 1-O- and 6-O-glucuronoyl-Dglucopyranoses and their stereoisomers derived from other hexoses have until now not been synthesized and studied in depth.
Location
DUC Ballroom A&B
Format
Poster Presentation
Novel 1→6- & 6→6-linked ester disaccharide analogs – synthesis and structural evaluation
DUC Ballroom A&B
Carbohydrate mimetics have been an active area of drug discovery, especially with regard to their potential use as glycosidase inhibitors. The ‘ester disaccharide’ motif is rare in nature, but has previously found use in a “redox glycosylation” approach to stereoselective glycosydic linkage, as well as in the development of trehalose-based compounds for drug delivery matrices. However, the basic 1-O- and 6-O-glucuronoyl-Dglucopyranoses and their stereoisomers derived from other hexoses have until now not been synthesized and studied in depth.
