Analysis of new Theosemicarbazones Against the Human Protozoal Parasite Trichomonas vaginalis
Poster Number
52
Format
Poster Presentation
Faculty Mentor Name
Kirkwood Land
Faculty Mentor Department
Biological Sciences
Abstract/Artist Statement
Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The current FDA approved drugs for treatment of human trichomoniasis are metronidazole and tinidazole. Current data from the US Centers for Disease Control and Prevention have suggested that almost 5% of all clinical cases of trichomoniasis show some level of resistance to these drugs. In search of new chemotherapies, we have screened a small compound library of thiosemicarbazones. Our laboratory has previously shown that this group of cysteine protease inhibitors has potent inhibitory activity against trichomonads protozoa. Our goal is to identify potential new chemotherapies against this important human parasite.
Location
Grave Covell
Start Date
21-4-2012 10:00 AM
End Date
21-4-2012 12:00 PM
Analysis of new Theosemicarbazones Against the Human Protozoal Parasite Trichomonas vaginalis
Grave Covell
Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The current FDA approved drugs for treatment of human trichomoniasis are metronidazole and tinidazole. Current data from the US Centers for Disease Control and Prevention have suggested that almost 5% of all clinical cases of trichomoniasis show some level of resistance to these drugs. In search of new chemotherapies, we have screened a small compound library of thiosemicarbazones. Our laboratory has previously shown that this group of cysteine protease inhibitors has potent inhibitory activity against trichomonads protozoa. Our goal is to identify potential new chemotherapies against this important human parasite.