Enhancement of fast neutron beams with Boron Neutron Capture Theory: A mechanism for achieving a selective, concomitant tumor boost
ORCiD
0000-0001-9010-5970
Document Type
Article
Publication Title
Acta Oncologica
ISSN
0284-186X
Volume
33
Issue
3
DOI
10.3109/02841869409098422
First Page
307
Last Page
307
Publication Date
1-1-1994
Abstract
Both fast neutron radiotherapy and boron neutron capture therapy (BNCT) have been utilized to treat malignant disease. Herein we discuss the potential of combining these treatments to enhance the effectiveness of fast neutron therapy through a concomitant BNCT boost. Using a fast neutron beam generated from a 50 MeV proton on beryllium reaction, we have determined that 0.1% of the beam per microgram of boron-10 per gram of tissue (microgram/g) can be deposited via BNCT. Our mathematical modeling predicts that BNCT enhancement of our beam will lead to an additional 1-2 logs of tumor cell kill for boron-10 concentrations of 30-50 micrograms/g. We have validated this via V-79 cell line in vitro measurements. A Poisson model estimation of how this additional cell kill will influence local tumor control, predicts that BNCT enhancement of fast neutron radiation will lead to a clinically significant improvement in outcome.
Recommended Citation
Buchholz, T. A.,
Laramore, G. E.,
Wootton, P.,
Livesey, J. C.,
Wilbur, D. S.,
Risler, R.,
Phillips, M. H.,
Jacky, J.,
&
Griffin, T. W.
(1994).
Enhancement of fast neutron beams with Boron Neutron Capture Theory: A mechanism for achieving a selective, concomitant tumor boost.
Acta Oncologica, 33(3), 307–307.
DOI: 10.3109/02841869409098422
https://scholarlycommons.pacific.edu/phs-facarticles/192
Comments
Presented at the Nordic Conference on Neutrons in Research and Cancer Therapy, 29-30 April, 1993, Linkoping, Sweden