Concomitant boron neutron capture therapy during fast neutron radiation of a rat glioma
ORCiD
0000-0001-9010-5970
Document Type
Article
Publication Title
Radiology
ISSN
0033-8419
Volume
191
Issue
3
DOI
10.1148/radiology.191.3.8184080
First Page
863
Last Page
867
Publication Date
6-1-1994
Abstract
PURPOSE: Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT. MATERIALS AND METHODS: Seventeen male Fisher rats, each weighing 180-200 g and bearing 36B10 gliomas, were irradiated with graded doses of fast-neutron radiation. Half of the animals received an L-para-boronophenylalanine (BPA) fructose complex prior to treatment. An in vitro colony-forming assay was used to measure surviving fraction. RESULTS: A significantly lower surviving fraction was noted in the tumors from the BPA group compared with those receiving neutrons alone at the three lower neutron doses (P < .005). With use of a linear quadratic curve fit of cell survival, the dose modifying factor was 1.32 at the 0.10 surviving fraction. Mean tumor boron concentration was 68.4 micrograms/g. CONCLUSIONS: BNCT enhancement of fast-neutron irradiation is feasible in an in vivo tumor system.
Recommended Citation
Buchholz, T. A.,
Rasey, J. S.,
Laramore, G. E.,
Livesey, J. C.,
Chin, L. K.,
Risler, R.,
Hamlin, D. K.,
Wootton, P.,
Wilbur, D. S.,
Phillips, M. H.,
Spence, A. M.,
&
Griffin, T. W.
(1994).
Concomitant boron neutron capture therapy during fast neutron radiation of a rat glioma.
Radiology, 191(3), 863–867.
DOI: 10.1148/radiology.191.3.8184080
https://scholarlycommons.pacific.edu/phs-facarticles/191
