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Theses/Dissertations from 2021

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Dissertation: Translationally-transformed coupled-cluster theory for periodic systems, Boris Daniel Gutierrez-Cortes

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Thesis: BAYESIAN-DERIVED VANCOMYCIN AUC24H THRESHOLD FOR NEPHROTOXICITY IN SPECIAL POPULATIONS, Dan Ho

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Thesis: Investigating the Specificity of Coiled-Coil Recognition, Melina Huey

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Dissertation: HARNESSING TRANSTHYRETIN TO ENHANCE THE IN VIVO HALF-LIFE OF HUMAN INTERLEUKIN-2 (IL-2), Fang Liu

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Thesis: Development of Linked-Domain Protein Inhibitors of the E2-Conjugating Enzyme Ube2D, Anneroos E. Nederstigt

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Dissertation: SYNTHESIS AND CONFORMATIONAL STUDY OF TRIAZOLYLCYCLOHEXANOLS AND TRANS-2-(AZAARYLSULFANYL)-CYCLOHEXANOLS, Mulinde R. Ruyonga

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Dissertation: IN VITRO COMPARATIVE STUDY OF THE BINDING AFFINITY AND TARGETED-DRUG DELIVERY EFFICIENCY OF EGFR-TARGETING PEPTIDES, Jingda Wang

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Dissertation: POST-TRANSLATIONAL MODIFICATION AND DEGRADATION MECHANISMS OF THE ARYL HYDROCARBON RECEPTOR, Yujie Yang

Theses/Dissertations from 2020

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Dissertation: REGULATION OF INTRACELLULAR ARYL HYDROCARBON RECEPTOR PROTEIN LEVELS, Jinyun Chen

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Thesis: Effects of Chronic Energy Drink Consumption on Cardiometabolic Endpoints, May Chen

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Thesis: midazole-based pH-sensitive Convertible Liposomes for Anticancer Drug Delivery, Ruiqi Huang

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Thesis: Multicellular spheroids of A549 and A549-iRFP as an in vitro model of lung cancer, Xinyu Pei

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Dissertation: STUDIES ON THE SIZE AND NON-PLANARITY OF AROMATIC STACKING MOIETY ON CONFORMATION SELECTIVITY AND THERMAL STABILIZATION OF G-QUADRUPLEXES, Mandeep Singh

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Dissertation: EXPLORATION OF CIS-1,2-DIAMINOCYCLOHEXANE-BASED CONFORMATIONALLY LOCKED CHIRAL LIGANDS IN ASYMMETRIC SYNTHESIS, Carim van Beek

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Dissertation: ELEPHANT AND ANCHORS ‒ PHOTOELECTRON PHOTOION COINCIDENCE SPECTROSCOPY OF SMALL OXYGENATED MOLECULES, aPeter Weidner

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Thesis: Development of Lipid-based Nano Formulations of Miriplatin Against Lung Cancer, Zizhao Xu

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Thesis: Role of Polymer Physicochemical Properties on in vitro Mucoadhesion, Qing Zhang

Theses/Dissertations from 2019

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Dissertation: Sexual Dimorphism in Aortic Function of UC Davis Type 2 Diabetes Mellitus Rat Model: Estrogen Specific Responses, Farjana Akther

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Thesis: Synthesis and Conformational Studies of Various Amides, Marcos Beltran-Sanchez

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Dissertation: The role of sex hormones on monocarboxylate transporter expression in tissues related to drug disposition, Jieyun Cao

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Dissertation: Exploring the Molecular Origin of Jet Fuel Thermal Oxidative Deposition Through Statistical Analysis of Mass Spectral Data and Pyrolysis Gas Chromatography/Mass Spectrometry of Deposits, Krege Matthew Christison

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Dissertation: Roaming Transition States and Highly Accurate Thermochemistry: A PEPICO Study of Two Small Combustion Systems, Kyle John Covert

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Dissertation: Development and Characterization of LDV Peptide Targeted Nanocarriers for Paclitaxel Delivery: A Comparative Study of Micelles, Liposomes and Solid Lipid Nanoparticles, Poonam Dattani

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Dissertation: Approaches to the Search of Platinum Anticancer Agents: Derivatizing Current Drugs and Incorporating HDAC Inhibition, Chao Feng

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Dissertation: Developing X-ray Spectromicroscopic Techniques to Quantitatively Determine Population Statistics and Individual Particle Composition of Complex Mixed Aerosols, Matthew Fraund

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Thesis: Intrapulmonary Inoculation of Multicellular Tumor Spheroids to Construct an Orthotopic Lung Cancer Xenograft Model that Mimics Four Clinical Stages of Non-small Cell Lung Cancer, Yingbo Huang

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Thesis: The Effect of Energy Drinks on Cardiovascular Variables: A Randomized Controlled Trial, Cynthia Lee

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Thesis: The potency of AG10 in stabilizing transthyretin is driven by interactions mimicking the disease-suppressing T119M variant, Dengpan Liang

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Dissertation: A COST CONTROL MODEL FOR INPATIENT MEDICATIONS AMONG ADULTS WITH MENTAL AND BEHAVIORAL HEALTH DISORDERS, Huanan Li

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Thesis: Investigating the Effect of Rutaecarpine on the Benzo[a]pyrene-Induced DNA Damage in vitro, You Li

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Dissertation: Fliposomes with a pH-sensitive conformational switch for anticancer drug delivery against triple negative breast cancer, Yifan Lu

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Dissertation: Development of a new class of ligand-targeted chemotherapeutics with enhanced safety and efficacy profile, Arindom Pal

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Dissertation: Knob-socket Investigation of Stability and Specificity in Alpha-helical Secondary and Quaternary Packing Structure, Taylor Renee Rabara

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Dissertation: I3: Isomerization of Isomer Ions, Krisztián Gabor Torma

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Dissertation: Developing a Rational Peptide Ligand Design Method Using CD13 as a Prototype Target Receptor, Md Zahir Uddin

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Dissertation: Lipid-coated Magnesium Phosphate Nanoparticles for Intrapulmonary Protein Delivery in Mice, Mallika Vadlamudi

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Dissertation: The role of aryl hydrocarbon receptor (AHR) in drug-drug interaction and the expression of AHR in Pichia Pastoris, Yujuan Zheng

Theses/Dissertations from 2018

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Thesis: DNA Lesions Produced from the Reaction of Diols and 5-Formylcytosine and Their Effects on DNA Replication, Brock Allen

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Thesis: Investigations on Cancer Cell Biological Effects of CDK8 Inhibitor Q-12, Zhixin Lu

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Dissertation: Mechanistic Study of p23-Mediated Aryl Hydrocarbon Receptor Expression, Beverly Pappas

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Dissertation: Bimetallic complexes: The fundamental aspects of metal-metal interactions, ligand sterics and application, Michael Bernard Pastor

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Dissertation: Development of Novel Phenanthroline and Thiazole Orange Derived G-quadruplex Ligands and Telomerase Inhibitors, Siwen Wang

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Thesis: Peptide-drug conjugate for Her2-targeted drug delivery, Yan Wang

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Thesis: Influence of the estrous cycle and female sex hormones on GHB toxicokinetics, Hao Wei

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Dissertation: Determining the role played by Aryl Hydrocarbon Receptor (AHR) in the colon carcinoma tumor model, Poonam Yakkundi

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Dissertation: Computational Methods in Biomolecules:Study of Hydrophilic Interactions in Protein Folding & Constant-pH Molecular Simulation of pH Sensitive Lipid MORC16, Wei Zhang

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Dissertation: Design and in vitro characterization of lipids with a pH-sensitive conformational switch and their liposomes for anticancer drug delivery, Shen Zhao

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Thesis: RATIONAL DESIGN OF PEPTIDES BINDING TOWARDS HUMAN PD-L1 USING KNOB-SOCKET MODEL, Xingchen Zha

Theses/Dissertations from 2017

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Dissertation - Pacific Access Restricted: Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer, Swetha Arikatla

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Thesis: Investigating Secondary Structure Features of YAP1 Protein Fragments Using Molecular Dynamics (MD) and Steered Molecular Dynamics (SMD) Simulations, Ferdiemar Cardenas Guinto Jr.

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Thesis: Synthesis of AG10 analogs and optimization of TTR ligands for Half-life enhancement (TLHE) of Peptides, Raghavendra Jampala

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Dissertation: Fragment-based Excitonic Coupled-Cluster Theory for Large Chemical Systems, Yuhong Liu

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Dissertation: Preclinical evaluation of AG10 for therapeutic use against familial amyloid cardiomyopathy and its application in various other technologies, Mark Russell Miller

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Thesis: The Rational Investigation of Anti-Cancer Peptide Specificity using the Knob-Socket Model, Shivarni Patel

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Thesis: SOLUBILITY ENHANCEMENT OF MODEL COMPOUNDS, Lavanya Pitani

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Thesis - Pacific Access Restricted: Soluble and Functional Overexpression of the Ligand Binding Domain of Mouse Aryl Hydrocarbon Receptor in E.Coli, Himaja Ponnakanti

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Thesis: CLINICAL FACTORS ASSOCIATED WITH HEPATITIS C TREATMENT SELECTION IN A VETERANS AFFAIRS POPULATION, Carly Anne Ranson

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Thesis - Pacific Access Restricted: Overexpression of Human Aryl Hydrocarbon Receptor in E.coli Using Two Different Solubility Enhancing Tags, Sravanthi Tejomurthula

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Thesis: Liposome-coated Magnesium Phosphate Nanoparticle for Delivery of Cytochrome C into Lung Cancer Cells A549, Weizhou Yue

Theses/Dissertations from 2016

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Dissertation - Pacific Access Restricted: Thermochemical differences in lysine and lysine-homolog containing oligopeptides: Determination of basicity and gas-phase structure through mass spectrometry, infrared spectroscopy, and computational chemistry, Patrick Henry M. Batoon

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Thesis - Pacific Access Restricted: Establishment of gas-phase thermochemical values of various small organic compounds and oligopeptides, Zachary Buen

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Dissertation - Pacific Access Restricted: First-principle based pharmacokinetic modeling, Jin Dong

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Thesis - Pacific Access Restricted: A tale of two small oxygenated molecules as told by photoelectron photoion coincidence spectroscopy, Chrissa Michelle Mozaffari Easter

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Thesis - Pacific Access Restricted: Explorations into protein structure with the knob-socket model, Keith Jeffrey Fraga

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Thesis - Pacific Access Restricted: Use of various health care providers and the associated clinical and humanistic outcomes in an ambulatory Medicare population, Yvonne M. Mai

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Dissertation - Pacific Access Restricted: Role of PRAS40 in mammalian target of rapamycin (mTOR) modulation in cancer and insulin resistance, Ritu Malla

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Thesis - Pacific Access Restricted: Catalase-loaded liposomal magnesium phosphate nanoparticles for intracellular protein delivery, Prathyusha Naidu

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Dissertation - Pacific Access Restricted: Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides, Sravan C. Penchala

Theses/Dissertations from 2015

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Dissertation - Pacific Access Restricted: Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro, William Sam Cao

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Thesis - Pacific Access Restricted: Effect of rutaecarpine on caffeine pharmacokinetics in rats, Rohit Kumar Estari

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Thesis - Pacific Access Restricted: Computational prediction of enhanced solubility of poorly aqueous soluble drugs prepared by hot melt method, Karthik Chalam Kondepudi

Thesis: Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method, Karthik Reddy Patlolla

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Dissertation - Pacific Access Restricted: Design and applications of antibody mimics against epidermal growth factor receptor, Sameer Sachdeva

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Dissertation - Pacific Access Restricted: Rational design, characterization and in vivo studies of antibody mimics against HER2, Dan Su

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Thesis - Pacific Access Restricted: Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique, Naresh Kumar Reddy Vutukuru

Theses/Dissertations from 2014

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Dissertation - Pacific Access Restricted: Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability, Manali Aggrawal

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Dissertation - Pacific Access Restricted: Exploring the molecular architecture of proteins: Method developments in structure prediction and design, Archana G. Chavan

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Thesis - Pacific Access Restricted: A novel intracellular protein delivery system - Magnesium phosphate nanoparticles with cationic lipid coating for catalase intracellular delivery, Yunzhou Fang

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Dissertation - Pacific Access Restricted: Sex differences in aortic endothelial function of diabetic rats: Possible involvement of superoxide and nitric oxide production, Xiaoyuan Han

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Dissertation - Pacific Access Restricted: RGD based peptide amphiphiles as drug carriers for cancer targeting, Poonam S. Saraf

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Dissertation - Pacific Access Restricted: Mechanism of tamoxifen resistance in breast cancer, Khyati Niral Shah

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Dissertation - Pacific Access Restricted: Mechanistic study of nanoemulsion absorption and its application for permeation enhancement, Yoshiko Katori Stowell

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Thesis - Pacific Access Restricted: Synthesis of poly(NIPAM-co-vmbpy) microspheres and transition metal monomers for metallopolymeric material construction, Carolyn Tran-Math

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Thesis - Pacific Access Restricted: Two approaches to the design and synthesis of bimetallic complexes, Yi-Ju Tsai

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Dissertation - Pacific Access Restricted: Study of the aryl hydrocarbon receptor as a target for rational drug design, Jinghang Xie

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Dissertation - Pacific Access Restricted: Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands, Dazhou Yang

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Dissertation - Pacific Access Restricted: Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model, Changfeng Zhang

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Dissertation - Pacific Access Restricted: Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model, Zhu Zhou

Theses/Dissertations from 2013

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Dissertation - Pacific Access Restricted: Very accurate gas-phase thermochemistry through photoelectron photoion coincidence (PEPICO) spectroscopy, Sampada N. Borkar

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Dissertation - Pacific Access Restricted: Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA, Priyanka Chitranshi

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Dissertation - Pacific Access Restricted: Investigation and characterization of the Direct Analysis in Real Time helium metastable beam open-air ion source: Mechanism of ionization, fluid dynamic visualization, and applications, Matthew Earl Curtis

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Dissertation: Turning stealth liposomes into cationic liposomes for anticancer drug delivery, Vijay Gyanani

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Dissertation - Pacific Access Restricted: Sublingual drug delivery: In vitro-in vivo correlation, Navdeep Kaur

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Dissertation - Pacific Access Restricted: Molecule recognition of nucleic acids, nucleosides, nucleotides, and their derivatives, Wanbo Liu

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Dissertation - Pacific Access Restricted: Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane, Xin Liu

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Thesis - Pacific Access Restricted: Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism, Swathi Vangala

Dissertation - Pacific Access Restricted: Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling, Yu Wang

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Dissertation - Pacific Access Restricted: New quinazoline analogues as NF-κB activation inhibitors, Lu Xu

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Dissertation - Pacific Access Restricted: Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors, Rui Zhang

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Dissertation - Pacific Access Restricted: Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery, Yu Zheng