Moscone was born (1929) and raised in San Francisco’s Marina district. He started a private law practice in San Francisco before serving on the San Francisco Board of Supervisors from 1963 to 1966 and in the California State Senate from 1967 to 1976. He was elected Mayor of San Francisco in December of 1975 and served from 1976 until his assassination in November of 1978. He supported changes that brought a greater diversity to the government of San Francisco. His collection focuses primarily on his political career.

The George Moscone Collection was processed in 2018 by Joseph Olson, Project Archivist. The work was made possible through grant funding from the National Archives National Historical Publications and Records Commissions (NHPRC).