A selection of conference proceedings, presentations, lectures, posters and symposia from faculty members of the Arthur A. Dugoni School of Dentistry at University of the Pacific.

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Submissions from 1998

pH Sensitive Liposomes: A Novel Approach in Antibiotic Delivery, Pattisapu R. J. Gangadharam, Diana Flasher, M. V. Reddy, and Nejat Düzgüneş

Incorporation of amphotericin B into stealth liposomes or colloidal dispersions diminishes its in vitro anti-HIV activity, Krystyna Konopka, Luke S. S. Guo, and Vladimir Slepushkin

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Effect of secretory leukocyte protease inhibitor on HIV infection in PM1 cells, Krystyna Konopka, Nancy R. Shine, and Nejat Düzgüneş

Activities of Free and Liposome-Encapsulated Sparfloxacin against Intracellular Drug-Susceptible and Multiple Drug Resistant (MDR) Tubercle Bacilli, Julieta Luna-Herrera, M. V. Reddy, Diana Flasher, Nejat Düzgüneş, and Pattisapu R. J. Gangadharam

A comparative study of fluorescent probes for monitoring virus fusion kinetics, Isabel Nunes-Correia, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Development of novel non-viral gene transfer vectors, Maria C. Pedroso de Lima, Rogério Gaspar, Sérgio Simões, Pedro Pires, Henrique Faneca, and Nejat Düzgüneş

Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection, Maria C. Pedroso de Lima, Sérgio Simões, Pedro Pires, Rogério Gaspar, Vladimir Slepushkin, and Nejat Düzgüneş

Role of lipid mixing in the physico-chemical properties of cationic liposome/DNA complexes and in their interaction with cells, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Insights into the interaction of lipoplex-mediated gene delivery: Fusion with or destabilization of the plasma membrane?, Pedro Pires, Sérgio Simões, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Enhancement of clarithromycin's water solubility via cyclodextrin complexation and efficacy study against Mycobacterium avium complex, Isam Ismail Salem and Nejat Düzgüneş

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Delivery of antisense oligonucleotides and ribozymes mediated by pH-sensitive liposomes enhances their anti-HIV effect, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Cellular uptake profile for zinc monoglycerolate (ZMG) in immune and gastric cell lines determined by fluorescence photomicrography and inductively coupled plasma mass spectrometry (ICP-MS), Benjamin David Zeitlin and Kim D. Rainsford

Submissions from 1997

Inhibition of HIV-1 replication by protease inhibitors, antisense oligonucleotides, and therapeutic genes delivered in liposomes, Nejat Düzgüneş, Krystyna Konopka, Elizabeth Pretzer, Vladimir A. Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, and John J. Rossi

Liposome-mediated delivery of antiviral drugs to HIV-infected cells, Nejat Düzgüneş, Elizabeth Pretzer, Krystyna Konopka, Vladimir Slepushkin, Sérgio Simões, Diana Flasher, G. S. Harrison, Nan S. Lee, E. De Clercq, and John J. Rossi

Gene delivery by anionic complexes of transferrin/cationic lipid/DNA., Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Diana Flasher, Rogério Gaspar, and Maria C. Pedroso de Lima

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusogenic peptides, Nejat Düzgüneş, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, and Maria C. Pedroso de Lima

Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev-binding aptamer and ribozyme DNAs, Krystyna Konopka, Nejat Düzgüneş, John J. Rossi, and Nan S. Lee

Inhibition of HIV infection by secretory leukocyte protease inhibitor, Krystyna Konopka, Nancy R. Shine, Elizabeth Pretzer, and Nejat Düzgüneş

Interaction of cationic liposomes with cells: Effect of several factors on liposome-cell fusion, Pedro C. Pires, Sérgio Simões, Rogério Gaspar, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Effect of recombinant secretory leukocyte protease inhibitor on HIV infection in human macrophages, Nancy Shine, Krystyna Konopka, and Nejat Düzgüneş

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Fusogenic liposomes in gene therapy: Design of novel non-viral systems for intracellular gene delivery, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Receptor ligand-mediated lipid-based gene delivery into T-lymphocytes, Sérgio Simões, Vladimir Slepushkin, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Transfection of human monocyte-derived macrophages by transferrin-cationic lipid-DNA complexes, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Rogério Gaspar, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Submissions from 1996

Sparfloxacin therapy of multidrug-resistant Mycobacterium tuberculosis infection in macrophages, Nejat Düzgüneş, M. V. Reddy, Diana Flasher, Julieta Luna-Herrera, and Pattisapu R. J. Gangadharam

HIV-regulated luciferase and diphtheria toxin A fragment genes are expressed specifically in HeLa cells after transfection by cationic liposomes, Krystyna Konopka, G. Harrison, Philip Felgner, and Nejat Düzgüneş

Delivery of anti-HIV-1 ribozyme into infected cells via cationic liposomes, Krystyna Konopka, John J. Rossi, Vladimir Slepushkin, and Nejat Düzgüneş

Interaction of cationic liposomes with cells: Insights into the mechanisms of intracellular gene transfer, Pedro Pires, Henrique Faneca, Sérgio Simões, Rogério Gaspar, Nejat Düzgüneş, and Maria C. Pedroso de Lima

A novel, highly potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor (UIC-94-003), Elizabeth Pretzer, Arun Ghosh, and Nejat Düzgüneş

Enhancement of the anti-HIV effect of antisense oligonucleotides by delivery in pH-sensitive liposomes, Vladimir A. Slepushkin, Elizabeth Pretzer, Sérgio Simões, Gerhard Steffan, Diana Flasher, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, and Nejat Düzgüneş

pH-sensitive liposomes with prolonged circulation for in vivo delivery of anti-HIV antisense oligonucleotides and antiviral genes, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, M. S. Newman, Luke S. Guo, Elizabeth Pretzer, Gerhard Steffan, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Sterically stabilized pH-sensitive liposomes: Mechanisms of intracellular delivery, Vladimir A. Slepushkin, Sérgio Simões, P. Dazin, Maria C. Pedroso de Lima, and Nejat Düzgüneş

Submissions from 1995

Liposome-encapsulated sparfloxacin, paromomycin, ciprofloxacin and clarithromycin for the therapy of Mycobacterium avium complex and Mycobacterium tuberculosis in macrophages, Nejat Düzgüneş, Diana Flasher, M. V. Reddy, Julieta Luna-Herrera, Isam I. Salem, and Pattisapu R. J. Gangadharam

Infected macrophages and differentiated chronically infected THP-1HIV-1IIIB cells are more sensitive to cytotoxic effects of cationic liposomes than uninfected cells, Krystyna Konopka, Elizabeth Pretzer, Philip Felgner, and Nejat Düzgüneş

Cationic liposome-mediated delivery of anti-HIV-1 ribozyme to chronically infected cells, Krystyna Konopka, John J. Rossi, Philip Felgner, and Nejat Düzgüneş

Inhibition of HIV-1 infection of macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease, Elizabeth Pretzer, Diana Flasher, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability as novel delivery vehicles for anti-HIV and anti-cancer drugs, Vladimir A. Slepushkin and Nejat Düzgüneş

Development of pH-sensitive liposomes stable in serum for delivery of anti-sense oligonucleotides, Vladimir A. Slepushkin, Diana Flasher, Elizabeth Pretzer, and Nejat Düzgüneş

pH-sensitive liposomes with serum stability, Vladimir Slepushkin and Nejat Düzgüneş

Liposome-bound cyclodextrin sulfates: a potential antiviral drug delivery system, Gerhard Steffan, C. Henke, H.J. Galla, and Nejat Düzgüneş

Submissions from 1994

Inhibition of phagosome-lysosome fusion by microorganisms phagocytosed by macrophages, Nejat Düzgüneş

Membrane fusion activity of simian and human immunodeficiency virus: Differential molecular requirements for membrane lipid mixing, nucleocapsid entry and cell-cell fusion, Nejat Düzgüneş, L. Stamatatos, Krystyna Konopka, F. Celada, and Elizabeth Pretzer

Targeting liposomes to cells infected with human immunodeficiency virus type 1 (HIV-1), Diana Flasher, Krystyna Konopka, S. Chamow, P. Dazin, A. Ashkenazi, Elizabeth Pretzer, and Nejat Düzgüneş

Differential effects of a monoclonal antibody to the gp120-CD4 complex on HIV-induced syncytium formation and viral infectivity, Krystyna Konopka, Elizabeth Pretzer, E. Seravalli, F. Celada, and Nejat Düzgüneş

Aerosolization in the Dental Environs, Nader A. Nadershahi

Role of target membrane sialic acid in the fusion activity of influenza virus, João Ramalho-Santos, Nejat Düzgüneş, Diana Flasher, Shlomo Nir, and Maria C. Pedroso de Lima

Submissions from 1993

Liposome-encapsulated antiviral agents inhibit HIV-1 replication in monocyte/macrophages and a chronically infected macrophage cell line, Nejat Düzgüneş, Diana Flasher, Elizabeth Pretzer, Krystyna Konopka, and S. Chamow

Long-term noncytopathic productive infection of the human monocytic leukemia cell line THP-1 by HIV-1IIIB, Krystyna Konopka, Elizabeth Pretzer, B. Plowman, and Nejat Düzgüneş

Aerosolization in the Dental Environs, Nader A. Nadershahi

Fusion kinetics of influenza virus: Differential pH requirements for fusion and inactivation, João Ramalho-Santos, Shlomo Nir, Nejat Düzgüneş, and Maria C. Pedroso de Lima

Submissions from 1992

Liposome targeting to HIV-infected cells via recombinant soluble CD4 and CD4-IgG (immunoadhesin), Nejat Düzgüneş, Diana Flasher, S. Chamow, A. Ashkenazi, P. Dazin, and Krystyna Konopka

CD4-Mediated targeting of liposomes to HIV-infected cells, Nejat Düzgüneş, Diana Flasher, Krystyna Konopka, and S. Chamow

Fusion activity of influenza and immunodeficiency viruses, Nejat Düzgüneş, L. Stamatatos, C. E. Larsen, Maria C. Pedroso de Lima, Dennis R. Alford, Krystyna Konopka, K-D. Lee, Elizabeth Pretzer, João Ramalho-Santos, Diana Flasher, and Shlomo Nir

Mechanisms of inhibition of HIV-1 infectivity by anionic liposomes, Krystyna Konopka, C. E. Larsen, and Nejat Düzgüneş

Interaction of simian immunodeficiency virus with CD4+ and CD4- cells: Envelope fusion, p27 entry and infectivity, L. Stamatatos and Nejat Düzgüneş

Submissions from 1991

Fusion of influenza and Sendai viruses with cultured cells, Nejat Düzgüneş, Maria Pedroso de Lima, L. Stamatatos, Diana Flasher, Daniel S. Friend, Dennis Alford, K. Klappe, Dick Hoekstra, and Shlomo Nir

Cardiolipin liposomes specifically inhibit HIV-1 infectivity, Krystyna Konopka, B. R. Davis, C. E. Larsen, and Nejat Düzgüneş

Fusion of HIV-1 with liposomes and erythrocyte ghosts, C. E. Larsen, Dennis R. Alford, Shlomo Nir, M. Jennings, K-D. Lee, and Nejat Düzgüneş

Kinetics of HIV-1 fusion with liposomes and erythrocyte ghosts, C. E. Larsen, Shlomo Nir, Dennis R. Alford, M. Jennings, K-D. Lee, and Nejat Düzgüneş

Submissions from 1990

HIV-1 blocks monocyte-mediated lysis of HIV-infected cells: Role of the HIV envelope protein, Robert J. Debs, John Krowka, Elisa N. Brunette, Daniel Stites, Ramila Philip, and Nejat Düzgüneş

Developments in liposome-mediated chemotherapy and immunotherapy of HIV and Mycobacterium avium complex infections, Nejat Düzgüneş, Krystyna Konopka, C. Larsen, Diana Flasher, John Krowka, Daniel Stites, B. Davis, D. Ashtekar, Pattisapu Gangadharam, and Robert Debs

Fusion of immunodeficiency, influenza and Sendai viruses with liposomes and cultured cells, Nejat Düzgüneş, C. Larsen, Maria C. Pedroso de Lima, Dennis Alford, Diana Flasher, L. Young, T. McGraw, M. Jennings, K. Klappe, Dick Hoekstra, and Shlomo Nir

Development of a nucleoplasmic reticulum in CV1 cells following incorporation of cationic DOTMA liposomes, Daniel S. Friend, Robert Debs, L. Freedman, Nejat Düzgüneş, and K. Yamamoto

Interaction between DOTMA liposomes, CV1 and U937 cells, and their isolated nuclei, Daniel S. Friend, Robert J. Debs, and Nejat Düzgüneş

Chemotherapeutic assessment of free and liposome-encapsulated streptomycin against Mycobacterium avium complex infections in beige mice, Pattisapu R. J. Gangadharam, N. Ghori, D. Ashtekar, Nejat Düzgüneş, and Robert Debs

Inhibition and enhancement of HIV-1 infectivity by liposomes, Krystyna Konopka, B. R. Davis, C. E. Larsen, Dennis R. Alford, Robert J. Debs, and Nejat Düzgüneş

Fusion of HIV-1 with liposomes, C. Larsen, Dennis R. Alford, M. Jennings, Robert Debs, and Nejat Düzgüneş

Fusion of Sendai and influenza viruses with cultured cells: Insights towards cell infection, Maria C. Pedroso de Lima, João Ramalho-Santos, M. F. Martins, and Nejat Düzgüneş

Submissions from 1989

Comparative study of fluorescent assays for contents mixing and leakage in lipid vesicles, Dennis Alford, Nejat Düzgüneş, and Joe Bentz

Inositol phosphate formation is regulated by neurotransmitters and neuropeptides in cultured human non-pigmented ciliary epithelium, R. B. Cook, N. Bazan, Nejat Düzgüneş, and J. R. Polansky

Membrane-associated TNF retains bioactivity in the presence of neutralizing anti-TNF antibodies, Robert J. Debs, Nejat Düzgüneş, Elisa N. Brunette, B. Fendly, J. Patton, and Ramila Philip

Therapy of Mycobacterium avium complex (MAC) infections in beige mice and peritoneal macrophages with liposome-encapsulated aminoglycosides and cytokines, Nejat Düzgüneş, L. Kesavalu, Veluchamy K. Permual, Jayne A. Goldstein, Elisa N. Brunette, Robert J. Debs, and Pattisapu R. J. Gangadharam

Liposome encapsulation facilitates enhanced killing effect of amikacin on Mycobacterium avium complex (MAC) in beige mice and macrophages, Pattisapu R. J. Gangadharam, L. Kesavalu, Jayne Goldstein, Robert J. Debs, and Nejat Düzgüneş

In vitro lymphocyte proliferative responses to recombinant and synthetic peptide antigens of HIV-1, John Krowka, Daniel Stites, K. Steimer, and Nejat Düzgüneş

Fusion of simian immunodeficiency virus (SIVmac) with liposomes and erythrocyte ghosts, C. Larsen, Dennis Alford, L. Young, K-D. Lee, T. McGraw, and Nejat Düzgüneş

Fusion of simian immunodeficiency virus (SIVmac) with phospholipid vesicles, erythrocyte ghosts and T-cell lines, C. Larsen, Dennis Alford, L. Young, K-D. Lee, T. McGraw, and Nejat Düzgüneş

Submissions from 1988

Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor-alpha in rats, Robert J. Debs and H. J. Fuchs

Monocyte cytolytic function is mediated by CD4, and is inhibited by HIV, Robert J. Debs, John Krowka, Daniel Stites, Elisa N. Brunette, Nejat Düzgüneş, and Ramila Philip

Therapy of Mycobacterium avium-intracellulare complex infection in macrophages and the Beige mouse model: Therapy with free and liposome-encapsulated antibiotics and immunomodulators, Nejat Düzgüneş, Pattisapu R. J. Gangadharam, Veluchamy K. Permual, Jayne Goldstein, L. Kesavalu, Elisa N. Brunette, D. Yajko, W. K. Hadley, and Robert J. Debs

Lymphocyte proliferation in response to immunodominant and conserved HIV peptides coupled to liposomes, Nejat Düzgüneş, John F. Krowka, Robert J. Debs, Jane Fedor, V. Maino, and Daniel P. Stites

Liposome-coupled synthetic immunodominant HIV peptides induce proliferation of lymphocytes from HIV-seropositive individuals, Nejat Düzgüneş, John F. Krowka, Ramila Philip, V. C. Maino, and Daniel P. Stites

Treatment of Mycobacterium avium-intracellulare complex infection in macrophages and Beige mice by free and liposome-encapsulated tumor necrosis factor-alpha (TNF), Nejat Düzgüneş, Veluchamy K. Permual, Elisa N. Brunette, Pattisapu R. J. Gangadharam, and Robert J. Debs

Influence of synthetic peptides derived from viral envelope proteins on the permeability and fusion of phospholipid vesicles, Nejat Düzgüneş and S. A. Shavnin

Activity of free and liposome-encapsulated amikacin against Mycobacterium avium complex (MAC), Pattisapu R. J. Gangadharam, Veluchamy K. Permual, L. Kesavalu, Robert J. Debs, Jayne Goldstein, and Nejat Düzgüneş

Comparative activities of free and liposome encapsulated amikacin against Mycobacterium avium complex (MAC), Pattisapu R. J. Gangadharam, Veluchamy K. Permual, L. Kesavalu, Robert J. Debs, Jayne Goldstein, and Nejat Düzgüneş

Comparative mycobactericidal action of free and liposome encapsulated amikacin on Mycobacterium avium complex (MAC) in peritoneal macrophages, L. Kesavalu, Veluchamy K. Permual, Nejat Düzgüneş, Robert Debs, and Pattisapu R. J. Gangadharam

Recognition of HIV-1 envelope glycoprotein (ENVgp) by antibodies and T cells from HIV-infected individuals, John Krowka, V. Maino, H. Hollander, Nejat Düzgüneş, and Daniel Stites

Interaction of Antimycobacterial and antipneumocystis drugs with phospholipid bilayers studied by differential scanning calorimetry, Maria C. Pedroso de Lima and Nejat Düzgüneş

The effects of the low molecular weight surfactant-associated proteins, SP-B and SP-C, on the thermotropic properties of various synthetic phospholipid membranes, Kathleen A. Shiffer, Samuel Hawgood, Nejat Düzgüneş, and Jon Goerke

Submissions from 1987

La3+ induced fusion of phosphatidylserine liposomes: Close approach, intermembrane intermediates and the electrostatic surface potential, Joe Bentz, Dennis Alford, J. Cohen, and Nejat Düzgüneş

Encapsulation of tumor necrosis factor (TNF) in liposomes: Characterization and effects on bioactivity, Robert J. Debs, Ramila Philip, Elisa N. Brunette, L. B. Epstein, and Nejat Düzgüneş

Lipid mixing during membrane aggregation and fusion, Nejat Düzgüneş, Theresa M. Allen, Jane Fedor, and Demetrios Papahadjopoulos

Membrane action of peptides from influenza hemagglutinin, Nejat Düzgüneş, F. Gambale, and Jane Fedor

Liposome-mediated therapy of Mycobacterium avium-intracellulare infections, Nejat Düzgüneş, Pattisapu Gangadharam, Jane Fedor, Veluchamy K. Permual, D. Perumal, D. Yajko, P. Minasi, D. Daleke, K. Hadley, and Robert Debs

Calcium-induced membrane fusion: From liposomes to cells, Demetrios Papahadjopoulos, Paul Meers, J. D. Ernst, I. M. Goldstein, Nejat Düzgüneş, and Keelung Hong

Ionotropic phase transitions and fusion of phospholipid vesicles are modulated by cholesterol, Maria C. Pedroso de Lima and Nejat Düzgüneş

Activity of liposomal preparations on phagocytosis and intracellular multiplication of Mycobacterium avium complex (MAC), Veluchamy K. Permual, Pattisapu R. J. Gangadharam, Nejat Düzgüneş, Robert Debs, Jane Fedor, N. R. Podapati, and M. D. Iseman