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The Guidebook to Molar Endodontics
Ove A. Peters
This volume offers readers a pragmatic approach to endodontic therapy for permanent molars, based on up-to-date evidence. All chapters were written by experts in the field, and focus on preparation for treatment, vital pulp therapy, access cavity preparation, root canal shaping, outcome assessment, retreatment, apical surgery, and specific aspects of restorations for root canal-treated molars. The role of micro-CT data in visualizing canal anatomy is compared to cone beam CT, and detailed information on current clinical tools, such as irrigation adjuncts and engine-driven preparation tools is provided. Important steps are illustrated in clinical photographs and radiographs, as well as by schematic diagrams. Tables and check boxes highlight key points for special attention, and clinical pitfalls. Guiding references are provided. Performing molar endodontics is often a daunting prospect, regardless of the practice setting. This is where “Molar Endodontics” is an ideal source of guidance for practitioners. Special devices and recent innovations in apex locators and nickel-titanium instruments have, however, made procedures significantly easier and more practical for non-specialists. This book will help conscientious clinicians to master molar endodontics with well-described and established clinical methods.
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Microbiome et santé
J. Martel, David M. Ojcius, C. J. Chang, Y. F. Ko, Hsin-Chih Lai, and John Ding-E Young
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Inflammasomes and danger signals in the immune system
Hsin-Chih Lai, Mufadhal Al-Kuhlani, David M. Ojcius, and Matthew A. Pettengill
The innate immune system has evolved to recognize both pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), which represent conserved microbial structures or generic markers of stress or damage, respectively, and to generate an appropriate response. One such response is the production of the critical cytokines interleukin-1β and interleukin-18, which follows incorporation of PAMP and DAMP signals, and requires the activation of protein complexes termed inflammasomes to generate mature cytokines.
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Shaping the root canal system to promote effective disinfection
Ove A. Peters and Frank Paque
Root canal shaping serves two main purposes in canal disinfection: direct mechanistic elimination of intracanal tissue and pathogens and providing optimal space for irrigant and medicament delivery. The process of root canal preparation should be considered a main driver of clinical success in endodontics. Mechanical canal preparation does not create contact with the full radicular surface and therefore all mechanical preparation is incomplete. Mechanical instrumentation, alone or in combination with an inert flushing solution such as saline, is effective in significantly reducing bacterial load. Two basic concepts govern a numerical approach to root canal shaping procedures: working length (WL) and apical size, recently also described as working width (WW). This chapter discusses the potential negative effects of shaping on disinfection and clinical data to support specific shaping paradigms.
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Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule
Benjamin David Zeitlin and Jacques E. Nör
Cancer has a complex etiology and displays a wide range of cellular escape pathways that allow it to circumvent treatment. Signaling molecules functionally downstream of the circumvented pathways, and particularly at checkpoints where several of these pathways intersect, provide valuable targets for the development of novel anti-cancer drugs. Bcl-2, a pro-survival signaling molecule, is one such protein. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins. The review focuses on the compounds with most available data within the literature and discusses both the anti-cancer and the recently unveiled anti-angiogenic potential of this new class of drugs.
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Practical Lessons in Endodontic Treatment
Donald Arens, Alan Gluskin, Christine I. Peters, and Ove A. Peters
This companion to the popular book Practical Lessons in Endodontic Surgery offers expert guidance to clinicians who have limited experience in the nonsurgical procedures involved in root canal therapy. Synthesizing the very latest clinical concepts and technologies with tried-and-true traditional treatment methods, it introduces readers to the challenges associated with nonsurgical endodontics and delivers realistic solutions in a clear, step-by-step, “lesson-based” format. Each of the 42 lessons offers useful, workable, and, above all, practical information and recommendations covering a specific aspect of endodontic care. Readers expand their knowledge incrementally, beginning with the essentials of patient diagnosis, examination, and record-keeping and progressing through lessons concerned with treatment planning and preparation for therapy; root canal instrumentation and obturation; and emergency and adjunctive procedures.
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Rotary Instrumentation: An Endodontic Perspective
Ove A. Peters
This issue gives clinicians a knowledgebase for NiTi rotary use and aims to enable them to select a system that is most suitable for their needs. This issues also includes several clinical "Golden Rules" for NiTi rotary preperation, and overview of available NiTi instrument systems on the market and more. Incorporates 19 illustrations.
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A pathogen with two personalities: death and survival during infection with Chlamydia
Philippe Verbeke, Lynn Stahl, Thomas Jungas, Christiane Delarbre, and David M. Ojcius
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Wurzelkanalpräparation mit Profile-Instrumenten
Ove A. Peters, C. Eggert, C. Schrader, and Fred Barbakow
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Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration. In: Copper and Zinc in Inflammatory and Degenerative Diseases
Kim D. Rainsford and Benjamin David Zeitlin
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Wurzelkanalpräparation mit Lightspeed-Instrumenten
Ove A. Peters, C. Eggert, Fred Barbakow, and F. Lutz
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Resistance of effector cells to perforin-mediated cytolysis
M. Fatima M. Horta, David M. Ojcius, and John Ding-E Young
A selection of published books and book chapters written or edited by faculty members of the Arthur A. Dugoni School of Dentistry at University of the Pacific.
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