Mineralo-organic particles inhibit influenza A virus infection by targeting viral hemagglutinin activity

ORCiD

David Ojcius: https://orcid.org/0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Nanomedicine

ISSN

1743-5889

Volume

19

Issue

28

DOI

10.1080/17435889.2024.2403326

First Page

2375

Last Page

2390

Publication Date

9-25-2024

Abstract

Aim: Mineralo-organic particles, naturally present in human body fluids, participate in ectopic calcification and inflammatory diseases. These particles coexist with influenza A virus (IAV) in the same microenvironment during viral infection. Our objective was to investigate the functional consequences of the potential interactions between these particles and the virions. Materials & methods: We used in vitro models, including electron microscopy, fluorescence microscopy, hemagglutination assay and viral infection assays to examine the interactions. Results: Mineralo-organic particles bind to IAV virions through interactions involving particle-bound fetuin-A and mineral content, effectively engaging viral hemagglutinin. These interactions result in hindered viral infection. Conclusion: These findings uncover the novel interactions between mineralo-organic particles and IAV, highlighting the impact of virus microenvironment complexity.

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