Biological functions of extracellular vesicles from mammalian cells

ORCiD

David Ojcius: https://orcid.org/0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Biomedical Journal

ISSN

2320-2890

Volume

47

Issue

5

DOI

10.1016/j.bj.2024.100788

First Page

1

Last Page

4

Publication Date

9-17-2024

Abstract

Extracellular vesicles (EVs) are enclosed by a phospholipid bilayer and can be secreted by most types of cells. EVs deliver cargo from the secreting cell into the cytoplasm of recipient cells, influencing the function of the recipient cells. EVs are attracting increasing attention from a broad range of clinicians and scientists due to their ability to promote or inhibit various physiological pathways or pathological conditions. This special issue of Biomedical Journal contains articles describing the biogenesis and biodistribution of EVs and their role in the intercellular transfer of various molecules or viruses to target cells, in rejecting allogeneic transplants and maintaining immune tolerance of the allogeneic fetus, and in modulating innate and adaptive immunity. Characterization of the role of EVs in various pathological conditions and our ability to engineer modified EVs may lead to discovery of novel biomarkers and development of therapeutic strategies for treatment of disease.

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