Lifestyle interventions to delay senescence

Authors

Jan Martel, Chang Gung UniversityFollow
David M. Ojcius, University of the PacificFollow
John D. Young, Chang Gung Biotechnology CorporationFollow

ORCiD

David Ojcius: https://orcid.org/0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Biomedical Journal

ISSN

2320-2890

Volume

47

Issue

2

DOI

10.1016/j.bj.2023.100676

First Page

1

Last Page

5

Publication Date

3-10-2024

Abstract

Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.

Recommended Citation

Martel, J., Ojcius, D. M., & Young, J. D. (2024). Lifestyle interventions to delay senescence. Biomedical Journal, 47(2), 1–5. DOI: 10.1016/j.bj.2023.100676
https://scholarlycommons.pacific.edu/dugoni-facarticles/866