Is the inflammasome relevant for epithelial cell function?
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Microbes and Infection
ISSN
1286-4579
Volume
18
Issue
2
DOI
10.1016/j.micinf.2015.10.007
First Page
93
Last Page
101
Publication Date
2-1-2016
Abstract
Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity. We review here recent findings on inflammasomes found in epithelial tissues, highlighting the importance of these protein complexes in the response of epithelial tissues to microbial infections.
Recommended Citation
Santana, P. T.,
Martel, J.,
Lai, H.,
Perfettini, J.,
Kanellopoulos, J. M.,
Young, J. D.,
Coutinho-Silva, R.,
&
Ojcius, D. M.
(2016).
Is the inflammasome relevant for epithelial cell function?.
Microbes and Infection, 18(2), 93–101.
DOI: 10.1016/j.micinf.2015.10.007
https://scholarlycommons.pacific.edu/dugoni-facarticles/70
