ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Biomedical Journal
ISSN
2319-4170
Volume
39
Issue
4
DOI
10.1016/j.bj.2016.08.003
First Page
251
Last Page
260
Publication Date
8-1-2016
Abstract
Despite recent advances unraveling mechanisms of host–pathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions. As one of the most-studied oral pathogens, Porphyromonas gingivalis is considered as a keystone pathogen with a central role in development of periodontal disease. This pathogen needs to evade immune-mediated defense mechanisms and tolerate inflammation in order to survive in the host. In this review, we summarize evidence showing that purinergic signaling modulates P. gingivalis survival and cellular immune responses, and discuss the role played by inflammasome activation and cell death during P. gingivalis infection.
Recommended Citation
Silva, C.,
Morandini, A. C.,
Ojcius, D. M.,
&
Coutinho-Silva,, R.
(2016).
Purinergic signaling during Porphyromonas gingivalis infection.
Biomedical Journal, 39(4), 251–260.
DOI: 10.1016/j.bj.2016.08.003
https://scholarlycommons.pacific.edu/dugoni-facarticles/484
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
