pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety
241st American Chemical Society (ACS) National Meeting & Exposition
American Chemical Society (ACS)
March 27-31, 2011
Date of Presentation
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can serve as powerful conformational pH-triggers. Their protonation leads to a conformational flip due to a strong intramolecular hydrogen bond. This 'impulse' is mechanically transmitted by the cycle to induce a conformational change of a remote site, thus altering its properties. Variation of NR2 groups allows a tuning of the conformational equilibrium, which was studied by NMR. These triggers were used in pH-sensitive lipid vesicles for drug and gene delivery.
Samoshin, V. V.,
Samoshina, N. M.,
Chertkov, V. A.
pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety.
Paper presented at 241st American Chemical Society (ACS) National Meeting & Exposition in Anaheim, CA.