pH-Sensitive liposomes with new trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome membrane

Authors

Nataliya M. Samoshina, University of the PacificFollow
Xin Liu, University of the Pacific
Yu Zheng, University of the Pacific
Andreas H. Franz, University of the PacificFollow
Xin Guo, University of the PacificFollow
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Conference Presentation

Department

Chemistry

Conference Title

241st American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

Anaheim, CA

Conference Dates

March 27-31, 2011

Date of Presentation

3-28-2011

Abstract

We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: a protonation-induced conformational switch of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Here we report our latest studies on the pH-sensitivity of PEG-grafted liposomes containing various trans-2-aminocyclohexanol-based lipids in their membranes. These liposomes are stable at pH 7.4 and yet release their content in a few seconds in a slightly acidic medium. The triggering pH value depends on the structure of amino-group.

Comments

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Recommended Citation

Samoshina, N. M., Liu, X., Zheng, Y., Franz, A. H., Guo, X., & Samoshin, V. V. (2011). pH-Sensitive liposomes with new trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome membrane. Paper presented at 241st American Chemical Society (ACS) National Meeting & Exposition in Anaheim, CA.
https://scholarlycommons.pacific.edu/cop-facpres/328