Design and synthesis of b-amino alcohol based b-lactam-isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Medicinal Chemistry Communications
Department
Biological Sciences
ISSN
Print: 2040-2503, Electronic: 2040-2511
Volume
4
Issue
6
DOI
10.1039/c3md00057e
First Page
1018
Last Page
1024
Publication Date
4-16-2013
Abstract
We have described the synthesis of β-amino alcohol based β-lactam–isatin chimeras along with their in vitro evaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of β-lactam and C-5 of isatin with preference for a chloro-substituent for good activity.
Recommended Citation
Nisha.,
Mehra, V.,
Hopper, M.,
Patel, N.,
Hall, D.,
Wrischnik, L. A.,
Land, K. M.,
&
Kumar, V.
(2013).
Design and synthesis of b-amino alcohol based b-lactam-isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis.
Medicinal Chemistry Communications, 4(6), 1018–1024.
DOI: 10.1039/c3md00057e
https://scholarlycommons.pacific.edu/cop-facarticles/810
