Design and synthesis of b-amino alcohol based b-lactam-isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

Authors

Nisha, Guru Nanak Dev University
Vishu Mehra, Guru Nanak Dev University
Melissa Hopper, University of the Pacific
Neal Patel, University of the Pacific
Dominique Hall, University of the Pacific
Lisa A. Wrischnik, University of the PacificFollow
Kirkwood M. Land, University of the PacificFollow
Vipan Kumar, Guru Nanak Dev UniversityFollow

ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

Medicinal Chemistry Communications

Department

Biological Sciences

ISSN

Print: 2040-2503, Electronic: 2040-2511

Volume

4

Issue

6

DOI

10.1039/c3md00057e

First Page

1018

Last Page

1024

Publication Date

4-16-2013

Abstract

We have described the synthesis of β-amino alcohol based β-lactam–isatin chimeras along with their in vitro evaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of β-lactam and C-5 of isatin with preference for a chloro-substituent for good activity.

Recommended Citation

Nisha., Mehra, V., Hopper, M., Patel, N., Hall, D., Wrischnik, L. A., Land, K. M., & Kumar, V. (2013). Design and synthesis of b-amino alcohol based b-lactam-isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis. Medicinal Chemistry Communications, 4(6), 1018–1024. DOI: 10.1039/c3md00057e
https://scholarlycommons.pacific.edu/cop-facarticles/810