Polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Dalton Transactions
Department
Biological Sciences
ISSN
Print: 1477-9226, Electronic: 1477-9234
Volume
44
Issue
33
DOI
10.1039/c5dt02378e
First Page
14906
Last Page
14917
Publication Date
9-7-2015
Abstract
A series of mono- and bis-salicylaldimine ligands and their corresponding Rh(I) complexes were prepared. The compounds were characterised using standard spectroscopic techniques including NMR, IR spectroscopy and mass spectrometry. The salicylaldimine ligands and complexes were screened for antiparasitic activity against two strains of Plasmodium falciparum i.e. the NF54 CQ-sensitive and K1 CQ-resistant strain as well as against the G3 isolate of Trichomonas vaginalis. The monomeric salicylaldimine quinolines exhibited good activity against the NF54 strain and the dimeric salicylaldimine quinolines exhibited no cross resistance across the two strains. The binuclear 5-chloro Rh(I) complex displayed the best activity against the Trichomonas vaginalis parasite, possibly a consequence of its enhanced lipophilicity. The compounds were also screened for cytotoxicity in vitro against WHCO1 oesophageal cancer cells. The monomeric salicylaldimine quinolines exhibited high selectivity towards malaria parasites compared to cancer cells, while the dimeric compounds were less selective.
Recommended Citation
Stringer, T.,
Taylor, D.,
Guzgay, H.,
Shokar, A.,
Au, A.,
Smith, P. J.,
Hendricks, D. T.,
Land, K. M.,
Egan, T. J.,
&
Smith, G. S.
(2015).
Polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis.
Dalton Transactions, 44(33), 14906–14917.
DOI: 10.1039/c5dt02378e
https://scholarlycommons.pacific.edu/cop-facarticles/806
