Title
Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Journal of agricultural and food chemistry
Department
Biological Sciences
ISSN
Print: 0021-8561, Electronic: 1520-5118
Volume
66
Issue
30
DOI
10.1021/acs.jafc.8b01726
First Page
7942
Last Page
7947
Publication Date
8-1-2018
Abstract
Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a sexually transmitted protozoan parasite that causes the human disease trichomoniasis. Two distinct strains of the related Tritrichomonas fetus infect cattle and cats. The glycoalkaloids α-chaconine and α-solanine were highly active against all parasite lines, while their common aglycone solanidine was only mildly inhibitory. α-Solanine was several times more active than α-chaconine. The phenolic compounds caffeic and chlorogenic acids and quercetin were mildly active against the parasites. Most of the potato peel samples were at least somewhat active against all three trichomonad species, but their activities were wide-ranging and did not correspond to their glycoalkaloid and phenolic content determined by HPLC. The two Russet samples were the most active against all three parasites. The purple potato peel sample was highly active against bovine and mostly inactive against feline trichomonads. None of the test substances were inhibitory toward several normal microflora species, suggesting the potential use of the peels for targeted therapeutic treatments against trichomonads.
Recommended Citation
Friedman, M.,
Huang, V.,
Quiambao, Q.,
Noritake, S.,
Liu, J.,
Kwon, O.,
Chintalapati, S.,
Young, J.,
Levin, C. E.,
Cheng, L. W.,
&
Land, K. M.
(2018).
Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads.
Journal of agricultural and food chemistry, 66(30), 7942–7947.
DOI: 10.1021/acs.jafc.8b01726
https://scholarlycommons.pacific.edu/cop-facarticles/794