ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
ACS Omega
Department
Biological Sciences
ISSN
2470-1343
Volume
3
Issue
5
DOI
10.1021/acsomega.8b00553
First Page
5808
Last Page
5813
Publication Date
5-30-2018
Abstract
In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Singh, A.,
Fong, G.,
Liu, J.,
Wu, Y.,
Chang, K.,
Park, W.,
Kim, J.,
Tam, C.,
Cheng, L. W.,
Land, K. M.,
&
Kumar, V.
(2018).
Synthesis and Preliminary Antimicrobial Analysis of Isatin- Ferrocene and Isatin-Ferrocenyl Chalcone Conjugates.
ACS Omega, 3(5), 5808–5813.
DOI: 10.1021/acsomega.8b00553
https://scholarlycommons.pacific.edu/cop-facarticles/792
