Synthesis and in vitro Evaluation of Palladium (II) Salicylaldiminato Thiosemicarbazone Complexes Against Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Journal of Inorganic Biochemistry
Department
Biological Sciences
ISSN
0162-0134
Volume
105
Issue
12
DOI
10.1016/j.jinorgbio.2011.07.023
First Page
1562
Last Page
1568
Publication Date
12-1-2011
Abstract
Eight mononuclear Pd(II) complexes containing salicylaldiminato thiosemicarbazones (saltsc-R; where R = H (1), 3-OMe (2), 3-tBu (3) and 5-Cl (4)) as dinegative tridentate ligands were prepared by the reaction of the corresponding thiosemicarbazone with the precursor Pd(L)2Cl2 (L = phosphatriazaadamantane or 4-picoline) in the presence of a weak base. These complexes (9–16) were characterised by a range of spectroscopic and analytical techniques including NMR spectroscopy and X-ray diffraction. These complexes along with four other Pd(II) analogues (5–8) were screened for activity in vitro against the Trichomonas vaginalis parasite. Preliminary results show that the type of ancillary ligand as well as the substituents on the aromatic ring of the salicylaldiminato thiosemicarbazone ligand influences the antiparasitic activity of these complexes.
Recommended Citation
Chellan, P.,
Stinger, T.,
Shokar, A.,
Dornbush, P. J.,
Vazquez-Anaya, G.,
Land, K. M.,
Chibale, K.,
&
Smith, G. S.
(2011).
Synthesis and in vitro Evaluation of Palladium (II) Salicylaldiminato Thiosemicarbazone Complexes Against Trichomonas vaginalis.
Journal of Inorganic Biochemistry, 105(12), 1562–1568.
DOI: 10.1016/j.jinorgbio.2011.07.023
https://scholarlycommons.pacific.edu/cop-facarticles/769
