Title

Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis

Authors

Amandeep Singh, Guru Nanak Dev University,
David Zhang, Univerisity of the Pacific
Christina C. Tam, Guru Nanak Dev University,
Luisa W. Cheng, Guru Nanak Dev University,
Kirkwood M. Land, University of the PacificFollow
Vipan Kumar, Guru Nanak Dev UniversityFollow

ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

Journal of Organometallic Chemistry

Department

Biological Sciences

ISSN

0022-328X

Volume

896

Issue

15

DOI

10.1016/j.jorganchem.2019.05.025

First Page

1

Last Page

4

Publication Date

9-1-2019

Abstract

Copper-promoted azide-alkyne cycloadditions were attempted to synthesize a series of variedly functionalized 1H-1,2,3-triazole-linked isatin-ferrocene, ferrocenylmethoxy-isatin and isatin-ferrocenyl-chalcone conjugates. The synthesized scaffolds were assayed for their inhibitory activity against T. vaginalis as well as several common normal human flora bacteria. The observed inhibitory activities against T. vaginalis and undetectable inhibition of microflora bacteria suggest that these compounds may be specific against trichomonad protozoa and could serve as a new scaffold for synthesis of novel compounds against this important human pathogen.

Recommended Citation

Singh, A., Zhang, D., Tam, C. C., Cheng, L. W., Land, K. M., & Kumar, V. (2019). Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis. Journal of Organometallic Chemistry, 896(15), 1–4. DOI: 10.1016/j.jorganchem.2019.05.025
https://scholarlycommons.pacific.edu/cop-facarticles/766