Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis
ORCID
Kirkwood M. Land: 0000-0001-5951-9630
Document Type
Article
Publication Title
Journal of Organometallic Chemistry
Department
Biological Sciences
ISSN
0022-328X
Volume
896
Issue
15
DOI
10.1016/j.jorganchem.2019.05.025
First Page
1
Last Page
4
Publication Date
9-1-2019
Abstract
Copper-promoted azide-alkyne cycloadditions were attempted to synthesize a series of variedly functionalized 1H-1,2,3-triazole-linked isatin-ferrocene, ferrocenylmethoxy-isatin and isatin-ferrocenyl-chalcone conjugates. The synthesized scaffolds were assayed for their inhibitory activity against T. vaginalis as well as several common normal human flora bacteria. The observed inhibitory activities against T. vaginalis and undetectable inhibition of microflora bacteria suggest that these compounds may be specific against trichomonad protozoa and could serve as a new scaffold for synthesis of novel compounds against this important human pathogen.
Recommended Citation
Singh, A.,
Zhang, D.,
Tam, C. C.,
Cheng, L. W.,
Land, K. M.,
&
Kumar, V.
(2019).
Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis.
Journal of Organometallic Chemistry, 896(15), 1–4.
DOI: 10.1016/j.jorganchem.2019.05.025
https://scholarlycommons.pacific.edu/cop-facarticles/766
