Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth

Authors

Milton H. Saier Jr., University of California, San Diego
Gregory A. Daniels, University of California, San Diego
Paula Boerner, University of California, San Diego
Joan Lin-Cereghino, University of California, San DiegoFollow

Document Type

Article

Publication Title

Journal of Membrane Biology

Department

Biological Sciences

ISSN

0022-2631

Volume

104

Issue

1

DOI

10.1007/BF01871898

First Page

1

Last Page

20

Publication Date

8-1-1988

Abstract

Amino acid uptake by a tissue cell in a multicellular organism appears to be one of several determinants of growth rate. While a multiplicity of transport systems for amino acids exists for the uptake of these essential nutrients, only a few of these have been subject to careful and critical analysis (see section B). Of these systems, one particular system, the system A transporter, has been found to be regulated by a wide variety of external stimuli and conditions (section C), and in some cells, its activity correlates reasonably well with growth state (section D). System A is thus one of the few identified transport systems which appears to be a target of protooncogene and oncogene action and regulator of cellular growth (section E). In this review, the evidence for this postulate is presented and evaluated.

Recommended Citation

Saier, M. H., Daniels, G. A., Boerner, P., & Lin-Cereghino, J. (1988). Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. Journal of Membrane Biology, 104(1), 1–20. DOI: 10.1007/BF01871898
https://scholarlycommons.pacific.edu/cop-facarticles/711