Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth

Document Type

Article

Publication Title

Journal of Membrane Biology

Department

Biological Sciences

ISSN

0022-2631

Volume

104

Issue

1

DOI

10.1007/BF01871898

First Page

1

Last Page

20

Publication Date

8-1-1988

Abstract

Amino acid uptake by a tissue cell in a multicellular organism appears to be one of several determinants of growth rate. While a multiplicity of transport systems for amino acids exists for the uptake of these essential nutrients, only a few of these have been subject to careful and critical analysis (see section B). Of these systems, one particular system, the system A transporter, has been found to be regulated by a wide variety of external stimuli and conditions (section C), and in some cells, its activity correlates reasonably well with growth state (section D). System A is thus one of the few identified transport systems which appears to be a target of protooncogene and oncogene action and regulator of cellular growth (section E). In this review, the evidence for this postulate is presented and evaluated.

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