Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth
Document Type
Article
Publication Title
Journal of Membrane Biology
Department
Biological Sciences
ISSN
0022-2631
Volume
104
Issue
1
DOI
10.1007/BF01871898
First Page
1
Last Page
20
Publication Date
8-1-1988
Abstract
Amino acid uptake by a tissue cell in a multicellular organism appears to be one of several determinants of growth rate. While a multiplicity of transport systems for amino acids exists for the uptake of these essential nutrients, only a few of these have been subject to careful and critical analysis (see section B). Of these systems, one particular system, the system A transporter, has been found to be regulated by a wide variety of external stimuli and conditions (section C), and in some cells, its activity correlates reasonably well with growth state (section D). System A is thus one of the few identified transport systems which appears to be a target of protooncogene and oncogene action and regulator of cellular growth (section E). In this review, the evidence for this postulate is presented and evaluated.
Recommended Citation
Saier, M. H.,
Daniels, G. A.,
Boerner, P.,
&
Lin-Cereghino, J.
(1988).
Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth.
Journal of Membrane Biology, 104(1), 1–20.
DOI: 10.1007/BF01871898
https://scholarlycommons.pacific.edu/cop-facarticles/711